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2121por Gonçalves, Lucas Pantoja, dos Santos, Thiago Vasconcelos, Campos, Marliane Batista, Lima, Luciana Vieira do Rêgo, Ishikawa, Edna Aoba Yassui, Silveira, Fernando Tobias, Ramos, Patrícia Karla Santos“…INTRODUCTION: In the Belém Metropolitan Region (BMR), Pará State, Brazil, American cutaneous leishmaniasis (ACL) is endemic; however, very little is known regarding its causative agents. …”
Publicado 2020
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2122por Gelaye, Kassahun Alemu, Demissie, Getu Debalkie, Ayele, Tadesse Awoke, Wami, Sintayehu Daba, Sisay, Malede Mequanent, Akalu, Temesgen Yihunie, Teshome, Destaw Fetene, Wolde, Haileab Fekadu“…OBJECTIVE: Ethiopia has the second highest burden of visceral leishmaniasis (VL) next to Sudan. North West Ethiopia alone accounts for 60% of the national burden. …”
Publicado 2020
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2123por Pessoa-e-Silva, Rômulo, Trajano-Silva, Lays Adrianne Mendonça, Vaitkevicius-Antão, Victor, dos Santos, Wagner José Tenório, Magalhães, Franklin Barbalho, Moura, Danielle Maria Nascimento, Nakasone, Eiji Kevin Nakasone, de Lorena, Virgínia Maria Barros, de Paiva-Cavalcanti, Milena“…The development and application of safe and effective immunoprophylactic/immunotherapeutic agents against canine visceral leishmaniasis (CanL) have been pointed out as the only means for the real control of the disease. …”
Publicado 2021
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2124por Nweze, Justus Amuche, Mbaoji, Florence N., Li, Yan-Ming, Yang, Li-Yan, Huang, Shu-Shi, Chigor, Vincent N., Eze, Emmanuel A., Pan, Li-Xia, Zhang, Ting, Yang, Deng-Feng“…BACKGROUND: Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected communities, which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa, Asia, and the Americas. …”
Publicado 2021
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2125“…The diversity and seasonality for sandflies were studied in 2019 at a focus of zoonotic cutaneous leishmaniasis in Zagora province, southern Morocco. Standardized sampling with CDC light traps was used. …”
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2126“…Leishmania infantum chagasi is the causative agent and Lutzomyia longipalpis is the main vector of visceral leishmaniasis in the Americas. We investigated the expression of Leishmania genes within L. longipalpis after artificial infection. mRNAs from genes involved in sugar and amino acid metabolism were upregulated at times of high parasite proliferation inside the insect. mRNAs from genes involved in metacyclogenesis had higher expression in late stages of infection. …”
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2127“…BACKGROUND: A higher caseload of visceral leishmaniasis (VL) has been observed among males in community-based surveys. …”
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2128por Zeleke, Ayalew Jejaw, Derso, Adane, Yeshanew, Arega, Mohammed, Rezika, Fikre, Helina“…BACKGROUND: Cutaneous leishmaniasis (CL), which is one form of leishmaniasis, may show variations over years across regions, and epidemiological studies are crucial to estimate the cases of the disease status over a long time. …”
Publicado 2021
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2129por Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., de Oca, Marcela Montes, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude, Sundar, Shyam, Engwerda, Christian R.“…Here, we identify type I IFNs as major upstream regulators of CD4(+) T cells from visceral leishmaniasis (VL) patients. Furthermore, we report that mice deficient in type I IFN signaling have significantly improved control of Leishmania donovani, a causative agent of human VL, associated with enhanced IFNγ but reduced IL-10 production by parasite-specific CD4(+) T cells. …”
Publicado 2020
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2130por ABDOLSALEHI, Mohammad Reza, MOHEBALI, Mehdi, KESHAVARZ, Hossein, MAHMOUDI, Shima, MAMISHI, Setareh“…Despite the fact that CGD patients are more susceptible to intracellular infections, visceral leishmaniasis has been reported rarely in these cases. …”
Publicado 2021
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2131por Cloots, Kristien, Marino, Pia, Burza, Sakib, Gill, Naresh, Boelaert, Marleen, Hasker, Epco“…BACKGROUND: Visceral leishmaniasis (VL) is on the verge of being eliminated as a public health problem in the Indian subcontinent. …”
Publicado 2021
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2132por Pappa, Styliani A., Kontou, Panagiota I., Bagos, Pantelis G., Braliou, Georgia G.“…Leishmaniasis is a neglected tropical disease affecting humans and domesticated animals with high mortality in endemic countries. …”
Publicado 2021
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2133por Farias Amorim, Camila, O. Novais, Fernanda, Nguyen, Ba T., Nascimento, Mauricio T., Lago, Jamile, Lago, Alexsandro S., Carvalho, Lucas P., Beiting, Daniel P., Scott, Phillip“…Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. …”
Publicado 2021
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2134por Kip, Anke E, Blesson, Séverine, Alves, Fabiana, Wasunna, Monique, Kimutai, Robert, Menza, Peninah, Mengesha, Bewketu, Beijnen, Jos H, Hailu, Asrat, Diro, Ermias, Dorlo, Thomas P C“…BACKGROUND: Despite high HIV co-infection prevalence in Ethiopian visceral leishmaniasis (VL) patients, the adequacy of antileishmanial drug exposure in this population and effect of HIV-VL co-morbidity on pharmacokinetics of antileishmanial and antiretroviral (ARV) drugs is still unknown. …”
Publicado 2021
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2135por Albalawi, Aishah E., Abdel-Shafy, Sobhy, Khudair Khalaf, Amal, Alanazi, Abdullah D., Baharvand, Parastoo, Ebrahimi, Katrin, Mahmoudvand, Hossein“…The in vitro antileishmanial activity of CuNPs (10–200 µg/mL) or MA alone (10–200 µg/mL), and various concentrations of MA (10–200 μg/mL) along with 20 μg/mL of CuNPs, was assessed against the Leishmania major (MRHO/IR/75/ER) amastigote forms and, then tested on cutaneous leishmaniasis induced in male BALB/c mice by L. major. …”
Publicado 2021
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2136por Mendizábal-Cabrera, Renata, Pérez, Isabel, Becerril Montekio, Víctor, Pérez, Freddy, Durán, Erick, Trueba, Mei L.“…BACKGROUND: Cutaneous leishmaniasis (CL), endemic in Guatemala, mostly affects poor people living in the northern region. …”
Publicado 2021
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2137por Akao, Yuichiro, Canan, Stacie, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Itono, Sachiko, Kaki, Rina, Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Nakai, Hiromi, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shimada, Mitsuyuki, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin“…An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit for visceral leishmaniasis. In silico probing of five proprietary pharmaceutical company libraries enabled rapid expansion of the hit chemotype, alleviating initial concerns about the core chemical structure while simultaneously improving antiparasitic activity and selectivity index relative to the background cell line. …”
Publicado 2021
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2138por Batista-Santos, Fernanda, Dória, Diogo A.N., Sincurá, Yrllan R., Rosário, Samuel S., Fujiwara, Ricardo T., Barata, Ricardo A.“…Background: The present study was carried out in the rural and urban area of Diamantina/Minas Gerais (MG), an endemic municipality for visceral leishmaniasis (VL) in Brazil. Methods: Patient notification records, canine prevalence, and phlebotomine fauna were evaluated. …”
Publicado 2021
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2139por Ejazi, Sarfaraz Ahmad, Choudhury, Somsubhra Thakur, Bhattacharyya, Anirban, Kamran, Mohd, Pandey, Krishna, Das, Vidya Nand Ravi, Das, Pradeep, da Silva, Fernando Oliveira, Costa, Dorcas Lamounier, Costa, Carlos Henrique Nery, Rahaman, Mehebubar, Goswami, Rama Prosad, Ali, Nahid“…Visceral leishmaniasis (VL), a fatal parasitic infection, is categorized as being neglected among tropical diseases. …”
Publicado 2021
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2140por Castelli, Germano, Bruno, Federica, Reale, Stefano, Catanzaro, Simone, Valenza, Viviana, Vitale, Fabrizio“…In conclusion, this quantitative PCR can be used for the diagnosis of both human, canine and feline Leishmaniasis with high sensitivity and specificity, but also for evaluating treatment and the endpoint determination of leishmaniasis.…”
Publicado 2021
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