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2761por Satam, Vijay S., Pedada, Srinivasa Rao, Kamaraj, Pasumpon, Antao, Nakita, Singh, Apoorva, Hindupur, Rama Mohan, Pati, Hari N., Thompson, Andrew M., Launay, Delphine, Martin, Denis“…[Image: see text] A process suitable for kilogram-scale synthesis of (2R)-2-methyl-6-nitro-2-{[4-(trifluoromethoxy)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole (DNDI-VL-2098, 2), a preclinical drug candidate for the treatment of visceral leishmaniasis, is described. The four-step synthesis of the target compound involves the Sharpless asymmetric epoxidation of 2-methyl-2-propen-1-ol, 8. …”
Publicado 2016
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2762por Pereira, Joyce Carvalho, Ramos, Tadeu Diniz, Silva, Johnatas Dutra, de Mello, Mirian França, Pratti, Juliana Elena Silveira, da Fonseca-Martins, Alessandra Marcia, Firmino-Cruz, Luan, Kitoko, Jamil Zola, Chaves, Suzana Passos, Gomes, Daniel Claudio De Oliveira, Diaz, Bruno Lourenço, Rocco, Patricia R. M., de Matos Guedes, Herbert Leonel“…Cutaneous leishmaniasis remains both a public health and a therapeutic challenge. …”
Publicado 2017
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2763por Membrive, Norberto Assis, Hisatugo, Flora, Silveira, Thaís Gomes Verzignassi, Teixeira, Jorge Juarez Vieira, Reinhold-Castro, Kárin Rosi, Teodoro, Ueslei“…The aim of this study was to better understand the dynamics of Leishmania sand flies and reservoirs in São Domingos ranch, Arapongas municipality, Paraná State, an anthropic environment in an endemic area of cutaneous leishmaniasis (CL). Sand flies were collected in wild animal burrows, residences and in the forest, with Falcão light trap (FA), Shannon trap (SH) and quadrangular pyramidal trap (QP). …”
Publicado 2017
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2764por Talmoudi, Khouloud, Bellali, Hedia, Ben-Alaya, Nissaf, Saez, Marc, Malouche, Dhafer, Chahed, Mohamed Kouni“…Transmission of zoonotic cutaneous leishmaniasis (ZCL) depends on the presence, density and distribution of Leishmania major rodent reservoir and the development of these rodents is known to have a significant dependence on environmental and climate factors. …”
Publicado 2017
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2765por Ferede, Getachew, Diro, Ermias, Getie, Sisay, Getnet, Gebeyaw, Takele, Yegnasew, Amsalu, Anteneh, Wondimeneh, Yitayih“…BACKGROUND: Despite high prevalence of visceral leishmaniasis and malaria in the study area, their coinfection remains unknown. …”
Publicado 2017
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2766por Benabid, Meriem, Ghrab, Jamila, Rhim, Adel, Ben-romdhane, Rania, Aoun, Karim, Bouratbine, Aïda“…Abundance, dynamics of density and Leishmania infantum infection prevalence of Phlebotomus perniciosus in Tunisian hot spot of visceral leishmaniasis highlight the major role of this Phlebotominae species in L. infantum transmission.…”
Publicado 2017
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2767por MAHMOUDVAND, Hossein, KHEIRANDISH, Farnaz, MIRBADIE, Seyed Reza, KAYEDI, Mohammad Hassan, REZAEI RIABI, Tahereh, GHASEMI, Abbas Ali, BAMOROVAT, Mehdi, SHARIFI, Iraj“…METHODS: The present study was carried out in 2014 in Leishmaniasis Research Center at School of Medicine, Kerman University of Medical sciences, Kerman, Iran. …”
Publicado 2017
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2768“…We therefore aimed to determine the insecticide susceptibility against two commonly used insecticides; deltamethrin and permethrin, on wild-caught sand fly populations collected in two geographically separated leishmaniasis endemic areas. METHODS: Insecticide susceptibility of wild-caught sand flies to deltamethrin (0.05%) and permethrin (0.75%) using ready-to use impregnated insecticide papers of WHO was investigated in 2010 based on knockdown time using standard WHO tube-test kit and procedures. …”
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2769“…BACKGROUND: Systemic treatments for Cutaneous Leishmaniasis (CL) have many limitations. Local therapies are an alternative option for this disease. …”
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2770por de la Cruz, María Luisa, Pérez, Andres, Domínguez, Mercedes, Moreno, Inmaculada, García, Nerea, Martínez, Irene, Navarro, Alejandro, Domínguez, Lucas, Álvarez, Julio“…Leishmaniasis, caused by Leishmania infantum, is a vector‐borne zoonotic disease that is endemic to the Mediterranean basin. …”
Publicado 2016
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2771por Dayakar, Alti, Chandrasekaran, Sambamurthy, Veronica, Jalaja, Bharadwaja, Vadloori, Maurya, Radheshyam“…Visceral leishmaniasis (VL) is responsible for several deaths in malnourished children accompanied by diminished circulating leptin and impaired cell-mediated immunity. …”
Publicado 2017
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2772por Mohammadiha, Anita, Dalimi, Abdolhossein, Mahmoodi, Mohammad Reza, Parian, Mehdi, Pirestani, Majid, Mohebali, Mehdi“…BACKGROUND: Leishmania tropica, the causative agent of anthroponotic cutaneous leishmaniasis (ACL), and Leishmania major, which causes zoonotic cutaneous leishmaniasis (ZCL), are endemic in Iran. …”
Publicado 2017
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2773por Morgado, F. N., de Carvalho, L. M. V., Leite-Silva, J., Seba, A. J., Pimentel, M. I. F., Fagundes, A., Madeira, M. F., Lyra, M. R., Oliveira, M. M., Schubach, A. O., Conceição-Silva, F.“…We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. …”
Publicado 2018
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2774por Garde, Esther, Ramírez, Laura, Corvo, Laura, Solana, José C., Martín, M. Elena, González, Víctor M., Gómez-Nieto, Carlos, Barral, Aldina, Barral-Netto, Manoel, Requena, José M., Iborra, Salvador, Soto, Manuel“…Antibodies against the different LieIF2 and LieIF2B subunits were found in the sera from human and canine visceral leishmaniasis patients, and also in the sera from hamsters experimentally infected with L. infantum. …”
Publicado 2018
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2775por Barroso, Daniel Holanda, Falcão, Sarah De Athayde Couto, da Motta, Jorgeth de Oliveira Carneiro, Sevilha dos Santos, Laís, Takano, Gustavo Henrique Soares, Gomes, Ciro Martins, Favali, Cecília Beatriz Fiuza, de Lima, Beatriz Dolabela, Sampaio, Raimunda Nonata Ribeiro“…INTRODUCTION: Diffuse cutaneous leishmaniasis (DCL) is a rare disease form associated with Leishmania (L.) amazonensis in South America. …”
Publicado 2018
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2776“…In addition, regarding the Americas, the specific relationship between canine and human for Visceral Leishmaniasis dynamics is still not well understood. …”
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2777por Ramalho, Dario Brock, da Silva, Rosiana Estéfane, de Senna, Maria Camilo Ribeiro, Moreira, Hugo Silva Assis, Pedras, Mariana Junqueira, de Avelar, Daniel Moreira, Saraiva, Lara, Rabello, Ana, Cota, Gláucia“…BACKGROUND: Cutaneous leishmaniasis (CL) is a world-wide health problem which currently lacks effective, affordable and easy to use therapy. …”
Publicado 2018
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2778por Masoori, Leila, Kheirandish, Farnaz, Haghighi, Ali, Mohebali, Mehdi, Akhoundi, Behnaz, Taghipour, Niloofar, Gachkar, Latif, Chegeni-Sharafi, Ali, Moin-Vaziri, Vahideh“…BACKGROUND: The fatal form of leishmaniasis is visceral form (VL), found in some of the countries in the world. …”
Publicado 2018
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2779por Oliveira, Agda M., López, Rossana V. M., Dibo, Margareth R., Rodas, Lilian A. C., Guirado, Marluci M., Chiaravalloti-Neto, Francisco“…BACKGROUND: In Brazil, visceral leishmaniasis (VL) is a serious public health problem because of its magnitude, geographical expansion and potential harms caused by illnesses, including death. …”
Publicado 2018
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2780por Carbone, Débora Cardozo Bonfim, Zanoni, Lourdes Zélia Garcia, Cônsolo, Fernanda Zanoni, Sanches, Simone Camargo, dos Reis, Vanessa Quadros, Muller, Karla de Toledo Candido, Carvalho, Cristiano Marcelo Espinola, Silva, Maria Cláudia“…Leishmaniasis is a disease complex with various clinical symptoms caused by different species of parasites of the genus Leishmania. …”
Publicado 2018
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