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3861por Coura-Vital, Wendel, Marques, Marcos José, Veloso, Vanja Maria, Roatt, Bruno Mendes, Aguiar-Soares, Rodrigo Dian de Oliveira, Reis, Levi Eduardo Soares, Braga, Samuel Leôncio, Morais, Maria Helena Franco, Reis, Alexandre Barbosa, Carneiro, Mariângela“…BACKGROUND: Various factors contribute to the urbanization of the visceral leishmaniasis (VL), including the difficulties of implementing control measures relating to the domestic reservoir. …”
Publicado 2011
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3862“…BACKGROUND: Leishmania species belong to the family Trypanosomatidae and cause leishmaniasis, a geographically widespread disease that infects humans and other vertebrates. …”
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3863por Vasconcellos, Raphael De Souza, Mariotini-Moura, Christiane, Gomes, Rodrigo Saar, Serafim, Tiago Donatelli, Firmino, Rafaela de Cássia, Silva e Bastos, Matheus, de Castro, Felipe Freitas, de Oliveira, Claudia Miranda, Borges-Pereira, Lucas, de Souza, Anna Cláudia Alves, de Souza, Ronny Francisco, Gómez, Gabriel Andres Tafur, Pinheiro, Aimara da Costa, Maciel, Talles Eduardo Ferreira, Silva-Júnior, Abelardo, Bressan, Gustavo Costa, Almeida, Márcia Rogéria, Baqui, Munira Muhammad Abdel, Afonso, Luís Carlos Crocco, Fietto, Juliana Lopes Rangel“…BACKGROUND: Visceral leishmaniasis is an important tropical disease, and Leishmania infantum chagasi (synonym of Leishmania infantum) is the main pathogenic agent of visceral leishmaniasis in the New World. …”
Publicado 2014
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3864por Pereira, Lais, Abbehusen, Melissa, Teixeira, Clarissa, Cunha, Jurema, Nascimento, Ivan P., Fukutani, Kyioshi, dos-Santos, Washington, Barral, Aldina, de Oliveira, Camila Indiani, Barral-Netto, Manoel, Soto, Manoel, Brodskyn, Cláudia Ida“…Histones and Acid Ribosomal proteins are already known to induce an effective immune response and have successfully been tested in the cutaneous leishmaniasis mouse model. Here, we investigate the protective ability of L. infantum nucleosomal histones (HIS) and ribosomal acidic protein P0 (LiP0) against L. infantum infection in the hamster model of visceral leishmaniasis using two different strategies: homologous (plasmid DNA only) or heterologous immunization (plasmid DNA plus recombinant protein and adjuvant). …”
Publicado 2015
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3865por Moreira, Nádia das Dores, Vitoriano-Souza, Juliana, Roatt, Bruno Mendes, Vieira, Paula Melo de Abreu, Coura-Vital, Wendel, Cardoso, Jamille Mirelle de Oliveira, Rezende, Mariana Trevisan, Ker, Henrique Gama, Giunchetti, Rodolfo Cordeiro, Carneiro, Claudia Martins, Reis, Alexandre Barbosa“…BACKGROUND: Leishmaniasis remains among the most important parasitic diseases in the developing world and visceral leishmaniasis (VL) is the most fatal. …”
Publicado 2016
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3866por Kyriazis, Ioannis D., Koutsoni, Olga S., Aligiannis, Nektarios, Karampetsou, Kalliopi, Skaltsounis, Alexios-Leandros, Dotsika, Eleni“…BACKGROUND: Much research effort has been focused on investigating new compounds derived from low-cost sources, such as natural products, for treating leishmaniasis. Oleuropein derived from numerous plants, particularly from the olive tree, Olea europaea L. …”
Publicado 2016
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3867por De Castro Levatti, Erica V., Toledo, Marcos S., Watanabe Costa, Renata, Bahia, Diana, Mortara, Renato A., Takahashi, Helio K., Straus, Anita H.“…Inositol phosphorylceramide (IPC), the major sphingolipid in the genus Leishmania but not found in mammals, is considered a potentially useful target for chemotherapy against leishmaniasis. Leishmania (Viannia) braziliensis is endemic in Latin America and causes American tegumentary leishmaniasis. …”
Publicado 2017
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3868por Chagas, Erica Cristina da Silva, Silva, Arineia Soares, Fé, Nelson Ferreira, Ferreira, Lucas Silva, Sampaio, Vanderson de Souza, Terrazas, Wagner Cosme Morhy, Guerra, Jorge Augusto Oliveira, Souza, Rodrigo Augusto Ferreira de, Silveira, Henrique, Guerra, Maria das Graças Vale Barbosa“…BACKGROUND: Phlebotomine sand flies (Diptera: Psychodidae) are vectors of Leishmania species, the etiological agents of leishmaniasis, which is one of the most important emerging infectious diseases in the Americas. …”
Publicado 2018
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3869“…BACKGROUND: Leishmania infantum is the causative agent of human visceral leishmaniasis (VL) and sporadic human cutaneous leishmaniasis (CL) in the Mediterranean region. …”
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3870por Fischer, Janneke, Jansen, Benita, Rivera, Alberto, Gómez, Libardo J., Barbosa, Martha C., Bilbao, Jorge L., González, José M., Restrepo, Luis, Vidal, Yesenia, Peters, Ruth M. H., van Brakel, Wim H.“…Therefore; the present study aimed to validate several tools of the toolkit among people affected by leprosy or leishmaniasis in the cultural settings of Cartagena and Cúcuta, Colombia. …”
Publicado 2019
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3871“…Here, we focus on recent genome-wide association studies of visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). …”
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3872por Thorstenberg, Maria Luiza, Martins, Monique Daiane Andrade, Figliuolo, Vanessa, Silva, Claudia Lucia Martins, Savio, Luiz Eduardo Baggio, Coutinho-Silva, Robson“…Leishmaniasis is a neglected tropical disease caused by an intracellular parasite of the genus Leishmania. …”
Publicado 2020
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3873“…ABSTRACT IMPACT: The first-line chemotherapies used to treat leishmaniasis are highly toxic intravenous antimonials yet drug resistance has begun to develop, causing the use of oral treatment options with high price tags; there is a strong need for new, safe, and effective chemotherapeutic agents to treat leishmaniasis. …”
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3874“…Leishmaniasis is a tropical disease that leads to various clinical phenotypes. …”
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3875“…BACKGROUND: Phlebotomus (Paraphlebotomus) sergenti is a widespread proven vector of Leishmania pathogens causing anthroponotic cutaneous leishmaniasis (ACL), due to L. tropica, in the old world. …”
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3876por Corman, Hannah N., Ross, Jessica N., Fields, Francisco R., Shoue, Douglas A., McDowell, Mary Ann, Lee, Shaun W.“…Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the protozoan parasite Leishmania species with a wide range of clinical manifestations. …”
Publicado 2022
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3877por Oliveira, Thamara K. F., Oliveira-Silva, Jullyanna, Linhares-Lacerda, Leandra, da Silva Fraga-Junior, Vanderlei, Benjamim, Claudia F., Guimaraes-Costa, Anderson B., Saraiva, Elvira M.“…Amastigotes maintain the infection in vertebrate hosts, and we have shown the association of NETs with amastigotes in human biopsies of cutaneous leishmaniasis. However, the interaction of amastigotes and neutrophils remains poorly understood. …”
Publicado 2023
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3878por Ullah, Imran, Barrie, Umaru, Kernen, Rebecca M., Mamula, Emily T., Khuong, Francis Tho Huu, Booshehri, Laela M., Rhodes, Emma L., Bradford, James M., Datta, Arani, Wetzel, Dawn M.“…Our results suggest potential for treating leishmaniasis using host cell-directed agents.…”
Publicado 2023
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3879por do Carmo Maquiaveli, Claudia, da Silva, Edson Roberto, Hild de Jesus, Barbara, Oliveira Monteiro, Caio Eduardo, Rodrigues Navarro, Tiago, Pereira Branco, Luiz Octavio, Souza dos Santos, Isabela, Figueiredo Reis, Nanashara, Portugal, Arieli Bernardo, Mendes Wanderley, João Luiz, Borges Farias, André, Correia Romeiro, Nelilma, de Lima, Evanoel Crizanto“…Leishmaniasis is a neglected tropical disease affecting millions of people worldwide. …”
Publicado 2023
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3880Publicado 1987“…The changes in distribution and turnover of T6+ Langerhans cells (LC) in the skin during delayed immune responses to tuberculin, and in the lesions of tuberculoid leprosy and cutaneous Leishmaniasis were investigated. In each situation, there was a dermal accumulation of monocytes and T cells and epidermal thickening with keratinocyte Ia expression. …”
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