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3961por Jarrad, Angie M., Ang, Chee Wei, Debnath, Anjan, Hahn, Hye Jee, Woods, Kyra, Tan, Lendl, Sykes, Melissa L., Jones, Amy J., Pelingon, Ruby, Butler, Mark S., Avery, Vicky M., West, Nicholas P., Karoli, Tomislav, Blaskovich, Mark A. T., Cooper, Matthew A.“…[Image: see text] Tuberculosis and parasitic diseases, such as giardiasis, amebiasis, leishmaniasis, and trypanosomiasis, all urgently require improved treatment options. …”
Publicado 2018
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3962por Chen, Han, Li, Jiao, Zhang, Junrong, Guo, Xianguang, Liu, Jinlong, He, Jinlei, Song, Qi, Zhang, Jianhui, Chen, Minli, Zheng, Zhiwan, Chen, Dali, Chen, Jianping“…BACKGROUND: Leishmaniasis caused by protozoan parasite Leishmania is a neglected disease which is endemic in the northwest of China. …”
Publicado 2019
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3963por Stensvold, Christen Rune, Høst, Amalie Vang, Belkessa, Salem, Nielsen, Henrik Vedel“…Lastly, we also present data on the associations between seroconversion and the type of leishmaniasis.…”
Publicado 2019
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3964por Machín, Laura, Tamargo, Beatriz, Piñón, Abel, Atíes, Regla C., Scull, Ramón, Setzer, William N., Monzote, Lianet“…Leishmaniasis is a group of neglected tropical diseases caused by protozoan parasites of the Leishmania genus. …”
Publicado 2019
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3965por Fadel, Hamza, Sifaoui, Ines, López-Arencibia, Atteneri, Reyes-Batlle, María, Jiménez, Ignacio A., Lorenzo-Morales, Jacob, Ghedadba, Nabil, Benayache, Samir, Piñero, José E., Bazzocchi, Isabel L.“…Leishmaniasis remains a major world health problem, and in particular, Algeria ranks second for the incidence of cutaneous leishmaniasis. …”
Publicado 2019
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3966por dos Santos Maia, Mayara, Raimundo e Silva, Joanda Paolla, de Lima Nunes, Thaís Amanda, Saraiva de Sousa, Julyanne Maria, Soares Rodrigues, Gabriela Cristina, Messias Monteiro, Alex France, Fechine Tavares, Josean, da Franca Rodrigues, Klinger Antonio, B. Mendonça-Junior, Francisco Jaime, Scotti, Luciana, Scotti, Marcus Tullius“…Leishmaniasis is endemic in at least 98 countries. Due to the high toxicity and resistance associated with the drugs, we chose lignans as an alternative, due to their favorable properties of absorption, distribution, metabolism, excretion, and toxicity (ADMET). …”
Publicado 2020
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3967por Sosa-Ochoa, Wilfredo, Zúniga, Concepción, Chaves, Luis Fernando, Araujo Flores, Gabriela Venicia, Sandoval Pacheco, Carmen Maria, Ribeiro da Matta, Vania Lúcia, Pereira Corbett, Carlos Eduardo, Tobias Silveira, Fernando, Dalastra Laurenti, Marcia“…Leishmania (Leishmania) infantum is the etiological agent of both American visceral leishmaniasis (AVL) and non-ulcerated cutaneous leishmaniasis (NUCL) in Honduras. …”
Publicado 2020
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3968por Adaui, Vanessa, Kröber-Boncardo, Constanze, Brinker, Christine, Zirpel, Henner, Sellau, Julie, Arévalo, Jorge, Dujardin, Jean-Claude, Clos, Joachim“…The protozoan parasite Leishmania (Viannia) braziliensis (L. braziliensis) is the main cause of human tegumentary leishmaniasis in the New World, a disease affecting the skin and/or mucosal tissues. …”
Publicado 2020
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3969por Medeiros, Andrea, Benítez, Diego, Korn, Ricarda S., Ferreira, Vinicius C., Barrera, Exequiel, Carrión, Federico, Pritsch, Otto, Pantano, Sergio, Kunick, Conrad, de Oliveira, Camila I., Orban, Oliver C. F., Comini, Marcelo A.“…A subset of analogues showed an improved potency (EC(50) 0.5–10 µM) and selectivity (20–35) against the clinically relevant stage of Leishmania braziliensis (mucocutaneous leishmaniasis) and L. infantum (visceral leishmaniasis). …”
Publicado 2020
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3970“…We will also discuss the distinct involvement of neutrophils in the outcome of leishmaniasis.…”
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3971por Terrazas, Paola, Salamanca, Efrain, Dávila, Marcelo, Manner, Sophie, Gimenez, Alberto, Sterner, Olov“…Many of the analogues prepared were shown to be more potent than pulchrol and the current drugs used to treat leishmaniasis and Chagas disease (miltefosine and benznidazole, respectively), in vitro. …”
Publicado 2021
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3972por Achilles, Genevere Reis, Kautzmann, Rafael Pinto, Chagas, Haile Dean Figueiredo, Pereira-Silva, Jordam William, Almeida, Jéssica Feijó, Fonseca, Fernanda Rodrigues, da Silva, Maria Nazareth Ferreira, Pessoa, Felipe Arley Costa, Nava, Alessandra Ferreira Dales, Ríos-Velásquez, Claudia María“…BACKGROUND: Trypanosomatids are widespread and cause diseases - such as trypanosomiasis, sleeping sickness, Chagas disease, and cutaneous and visceral leishmaniasis - in animals and humans. These diseases occur in both rural and urban regions due to unplanned growth and deforestation. …”
Publicado 2021
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3973por Oliveira, Byara Freitas Guedes, de Fátima Domingos, Maria, Ovallos, Fredy Galvis, de Camargo-Neves, Vera Lucia Fonseca“…The results presented reinforce the importance of these species in anthropized areas in the transmission of cutaneous leishmaniasis (CL) agents and the need for entomological monitoring. …”
Publicado 2021
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3974por Freitas, D.S.C., Silva, R.E., Costa, J.O.J., Markus, D.V., Soares, H.S., Minervino, A.H.H., Lima, J.T.R., Gennari, S.M., Marcili, A.“…Most species develop in a hematophagous arthropod and infect a specific vertebrate host that may belong to diverse orders and families. Visceral leishmaniasis is a chronic zoonosis with a wide geographic distribution, affecting 350 million people globally, mostly in areas with a high risk of infection. …”
Publicado 2022
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3975por Mao, Wei, Lazar, Noureddine, van Tilbeurgh, Herman, Loiseau, Philippe M., Pomel, Sébastien“…Background: Leishmaniasis, a vector-borne disease caused by the protozoan parasite from the genus Leishmania, is endemic to tropical and subtropical areas. …”
Publicado 2022
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3976por Bandeira Ferreira, Fabio Luiz, Séguin, Olivier, Descoteaux, Albert, Heinonen, Krista M.“…We have previously shown that HSPC activation promotes parasite persistence and expansion in experimental visceral leishmaniasis through the increased production of permissive monocytes. …”
Publicado 2022
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3977Detection of Leishmania spp. in Chronic Dermatitis: Retrospective Study in Exposed Horse Populationspor Gazzonis, Alessia Libera, Morganti, Giulia, Porcellato, Ilaria, Roccabianca, Paola, Avallone, Giancarlo, Gavaudan, Stefano, Canonico, Cristina, Rigamonti, Giulia, Brachelente, Chiara, Veronesi, Fabrizia“…Leishmania infantum is a protozoan causing human zoonotic visceral leishmaniasis (ZVL) and visceral–cutaneous canine leishmaniosis (CanL) in the Mediterranean Basin. …”
Publicado 2022
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3978“…INTRODUCTION: Leishmaniasis is still a neglected tropical disease that can endanger more than 350 million people among 98 countries. …”
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3979por Margaroni, Maritsa, Agallou, Maria, Tsanaktsidou, Evgenia, Kammona, Olga, Kiparissides, Costas, Karagouni, Evdokia“…Leishmaniasis is a vector-borne disease caused by an intracellular parasite of the genus Leishmania with different clinical manifestations that affect millions of people worldwide, while the visceral form may be fatal if left untreated. …”
Publicado 2023
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3980por Walkinshaw, Malcolm“…The need for an effective oral therapy for leishmaniasis is addressed through the study of the target N-myristoyltransferase from Leishmania major.…”
Publicado 2014
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