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4181por Senanayake, Sanath C, Liyanage, Prasad, Pathirage, Dulani R.K., Siraj, M. F. Raushan, Kolitha De Silva, B. G. D. Nissanka, Karunaweera, Nadira D“…BACKGROUND: Phlebotomine sand flies serve as vectors for leishmaniasis, a major health concern, but a neglected tropical disease. …”
Publicado 2023
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4182por Skinner, Eloise B., Glidden, Caroline K., MacDonald, Andrew J., Mordecai, Erin A.“…Across a spectrum of human pressure, diseases associated with lower human pressure, including malaria, cutaneous leishmaniasis and visceral leishmaniasis, give way to diseases associated with high human pressure, such as dengue, chikungunya and Zika. …”
Publicado 2023
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4183por Stögerer, Tanja, Silva-Barrios, Sasha, Carmona-Pérez, Liseth, Swaminathan, Sharada, Mai, Linh Thuy, Leroux, Louis-Philippe, Jaramillo, Maritza, Descoteaux, Albert, Stäger, Simona“…Polyclonal B cell activation and the resulting hypergammaglobulinemia are a detrimental consequence of visceral leishmaniasis (VL); however, the mechanisms underlying this excessive production of nonprotective antibodies are still poorly understood. …”
Publicado 2023
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4184por dos Santos, Fabíola Suelen, de Freitas, Rossimiriam Pereira, de Freitas, Camila Simões, Mendonça, Débora Vasconcelos Costa, Lage, Daniela Pagliara, Tavares, Grasiele de Sousa Vieira, Machado, Amanda Sanchez, Martins, Vivian Tamieti, Costa, Adilson Vidal, de Queiroz, Vagner Tebaldi, de Oliveira, Mariana Belizario, de Oliveira, Fabrício Marques, Antinarelli, Luciana Maria Ribeiro, Coimbra, Elaine Soares, Pilau, Eduardo Jorge, da Silva, Geovane Perez, Coelho, Eduardo Antonio Ferraz, Teixeira, Róbson Ricardo“…Leishmaniasis is a group of infectious diseases caused by protozoan parasites that belong to the genus Leishmania. …”
Publicado 2023
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4185por Aiman, Sara, Ahmad, Abbas, Khan, Azmat Ali, Alanazi, Amer M., Samad, Abdus, Ali, Syed Luqman, Li, Chunhua, Ren, Zhiguang, Khan, Asifullah, Khattak, Saadullah“…Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of leishmaniasis throughout the global tropics and subtropics. …”
Publicado 2023
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4186por de Moura, Tatiana R., Oliveira, Fabiano, Novais, Fernanda O., Miranda, José Carlos, Clarêncio, Jorge, Follador, Ivonise, Carvalho, Edgar M., Valenzuela, Jesus G., Barral-Netto, Manoel, Barral, Aldina, Brodskyn, Cláudia, de Oliveira, Camila I.“…Furthermore, in an endemic area of cutaneous leishmaniasis, patients with active lesions displayed higher levels of anti-L. intermedia saliva antibodies when compared to individuals with a positive skin test result for Leishmania. …”
Publicado 2007
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4187por Hassan, Mo'awia M, Osman, Omran F, El-Raba'a, Fathi MA, Schallig, Henk DFH, Elnaiem, Dia-Eldin A“…Host preference of the visceral leishmaniasis (VL) vector in the area, Phlebotomus orientalis, and other sandflies for the Nile rat (Arvicanthis niloticus, É. …”
Publicado 2009
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4188por Hostomská, Jitka, Volfová, Věra, Mu, Jianbing, Garfield, Mark, Rohoušová, Iva, Volf, Petr, Valenzuela, Jesus G, Jochim, Ryan C“…Enzymatic and immunological investigations further demonstrate the value of functional transcriptomics in advancing biological and epidemiological research that can impact leishmaniasis.…”
Publicado 2009
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4189por Sharlow, Elizabeth R., Close, David, Shun, Tongying, Leimgruber, Stephanie, Reed, Robyn, Mustata, Gabriela, Wipf, Peter, Johnson, Jacob, O'Neil, Michael, Grögl, Max, Magill, Alan J., Lazo, John S.“…Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities. …”
Publicado 2009
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4190por Mejia, J. Santiago, Toot-Zimmer, Amanda L., Schultheiss, Patricia C., Beaty, Barry J., Titus, Richard G.“…BACKGROUND: Visceral Leishmaniasis is a serious human disease transmitted, in the New World, by Lutzomyia longipalpis sand flies. …”
Publicado 2010
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4191“…The requirement for sustained and efficient vaccination against leishmaniasis is to formulate the best combination of immunopotentiating adjuvant with the stable antigen (Ag) delivery system. …”
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4192por Varela-M, Rubén E., Villa-Pulgarin, Janny A., Yepes, Edward, Müller, Ingrid, Modolell, Manuel, Muñoz, Diana L., Robledo, Sara M., Muskus, Carlos E., López-Abán, Julio, Muro, Antonio, Vélez, Iván D., Mollinedo, Faustino“…Pentavalent antimonials (SbV) are currently the first-line pharmacologic therapy for leishmaniasis worldwide, but resistance to these compounds is increasingly reported. …”
Publicado 2012
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4193por Paladi, Carolina de Siqueira, Pimentel, Isabella Aparecida Salerno, Katz, Simone, Cunha, Rodrigo L. O. R., Judice, Wagner Alves de Souza, Caires, Antonio C. F., Barbiéri, Clara Lúcia“…We believe these findings support the potential use of DPPE 1.2 as an alternative choice for the chemotherapy of leishmaniasis.…”
Publicado 2012
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4194por Hartley, Mary-Anne, Ronet, Catherine, Zangger, Haroun, Beverley, Stephen M., Fasel, Nicolas“…Curiously, LRVs were found mostly in clinical isolates prone to infectious metastasis in both their human source and experimental animal model, suggesting an association between the viral hyperpathogen and metastatic complications such as mucocutaneous leishmaniasis (MCL). MCL presents as chronic secondary lesions in the mucosa of the mouth and nose, debilitatingly inflamed and notoriously refractory to treatment. …”
Publicado 2012
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4195por Marzouki, Soumaya, Abdeladhim, Maha, Abdessalem, Chaouki Ben, Oliveira, Fabiano, Ferjani, Beya, Gilmore, Dana, Louzir, Hechmi, Valenzuela, Jesus G., Ahmed, Mélika Ben“…BACKGROUND: Zoonotic cutaneous leishmaniasis (ZCL) due to Leishmania major is highly prevalent in Tunisia and is transmitted by a hematophagous vector Phlebotomus papatasi (P. papatasi). …”
Publicado 2012
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4196por Oyola, Samuel O., Evans, Krystal J., Smith, Terry K., Smith, Barbara A., Hilley, James D., Mottram, Jeremy C., Kaye, Paul M., Smith, Deborah F.“…The single gene encoding cyclopropane fatty acid synthetase (CFAS) is present in Leishmania infantum, L. mexicana and L. braziliensis but absent from L. major, a causative agent of cutaneous leishmaniasis. In L. infantum, usually causative agent of visceral leishmaniasis, the CFAS gene is transcribed in both insect (extracellular) and host (intracellular) stages of the parasite life cycle. …”
Publicado 2012
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4197por Santos, Lívia O., Vitório, Bianca S., Branquinha, Marta H., Pedroso e Silva, Conceição M., Santos, André L. S., d'Avila-Levy, Claudia M.“…OBJECTIVES: There is a general lack of effective and non-toxic chemotherapeutic agents for leishmaniasis and there is as yet no study about the effect of HIV peptidase inhibitors (HIV PIs) on Leishmania/HIV-coinfected patients. …”
Publicado 2013
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4198por Deribe, Kebede, Meribo, Kadu, Gebre, Teshome, Hailu, Asrat, Ali, Ahmed, Aseffa, Abraham, Davey, Gail“…Ethiopia is estimated to have the highest burden of trachoma, podoconiosis and cutaneous leishmaniasis in sub-Saharan Africa (SSA), the second highest burden in terms of ascariasis, leprosy and visceral leishmaniasis, and the third highest burden of hookworm. …”
Publicado 2012
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4199por Seblova, Veronika, Volfova, Vera, Dvorak, Vit, Pruzinova, Katerina, Votypka, Jan, Kassahun, Aysheshm, Gebre-Michael, Teshome, Hailu, Asrat, Warburg, Alon, Volf, Petr“…BACKGROUND: Phlebotomus orientalis Parrot (Diptera: Psychodidae) is the main vector of visceral leishmaniasis (VL) caused by Leishmania donovani in East Africa. …”
Publicado 2013
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4200por de Moura, Tatiana R., Oliveira, Fabiano, Carneiro, Marcia W., Miranda, José Carlos, Clarêncio, Jorge, Barral-Netto, Manoel, Brodskyn, Cláudia, Barral, Aldina, Ribeiro, José M. C., Valenzuela, Jesus G., de Oliveira, Camila I.“…CONCLUSIONS: We identified the most abundant and novel proteins present in the SGs of Lu. intermedia, a vector of cutaneous leishmaniasis in the Americas. We also show for the first time that immunity to a single salivary protein from Lu. intermedia can protect against cutaneous leishmaniasis caused by L. braziliensis.…”
Publicado 2013
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