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4301por Doroud, Delaram, Zahedifard, Farnaz, Vatanara, Alireza, Taslimi, Yasaman, Vahabpour, Rouholah, Torkashvand, Fatemeh, Vaziri, Behrooz, Rouholamini Najafabadi, Abdolhossein, Rafati, Sima“…Furthermore, in developing vaccines for leishmaniasis, it is necessary to consider a proper adjuvant and/or delivery system to promote an antigen specific immune response. …”
Publicado 2011
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4302“…BACKGROUND: Phlebotomus chinensis is a primary vector of visceral leishmaniasis; it occurs in various biotopes with a large geographical distribution, ranging from Yangtze River to northeast China. …”
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4303por Matos, Ines, Mizenina, Olga, Lubkin, Ashira, Steinman, Ralph M., Idoyaga, Juliana“…Efficient vaccination against the parasite Leishmania major, the causative agent of human cutaneous leishmaniasis, requires development of type 1 T-helper (Th1) CD4(+) T cell immunity. …”
Publicado 2013
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4304por Weinkopff, Tiffany, de Oliveira, Camila I., de Carvalho, Augusto M., Hauyon-La Torre, Yazmin, Muniz, Aline C., Miranda, Jose Carlos, Barral, Aldina, Tacchini-Cottier, Fabienne“…During a blood meal, Lutzomyia intermedia sand flies transmit Leishmania braziliensis, a parasite causing tegumentary leishmaniasis. In experimental leishmaniasis, pre-exposure to saliva of most blood-feeding sand flies results in parasite establishment in absence of any skin damages in mice challenged with dermotropic Leishmania species together with saliva. …”
Publicado 2014
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4305por Sousa, Maria C., Varandas, Raquel, Santos, Rita C., Santos-Rosa, Manuel, Alves, Vera, Salvador, Jorge A. R.“…Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries, affecting more than 12 million people. …”
Publicado 2014
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4306por Reis-Cunha, João Luís, Mendes, Tiago Antônio de Oliveira, de Almeida Lourdes, Rodrigo, Ribeiro, Daihana Rodrigues dos Santos, Machado-de-Avila, Ricardo Andrez, de Oliveira Tavares, Maykon, Lemos, Denise Silveira, Câmara, Antônia Cláudia Jácome, Olórtegui, Carlos Chavez, de Lana, Marta, da Cunha Galvão, Lúcia Maria, Fujiwara, Ricardo Toshio, Bartholomeu, Daniella Castanheira“…The antigens used in these assays may have low specificity due to cross reactivity with antigens from related parasite infections, such as leishmaniasis, and low sensitivity caused by the high polymorphism among T. cruzi strains. …”
Publicado 2014
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4307por Costa, Luciana, Pinheiro, Roberta O., Dutra, Patrícia M. L., Santos, Rosiane F., Cunha-Júnior, Edézio F., Torres-Santos, Eduardo C., da Silva, Alcides J. M., Costa, Paulo R. R., Da-Silva, Silvia A. G.“…Taken together, these results show that the antileishmanial effect of LQB-118 extends to L. braziliensis in the hamster model, involves the induction of parasite apoptosis and shows promising therapeutic option by oral or local routes in leishmaniasis.…”
Publicado 2014
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4308por Lisi, Oscar, D’Urso, Vera, Vaccalluzzo, Valerio, Bongiorno, Gioia, Khoury, Cristina, Severini, Francesco, Di Muccio, Trentina, Gramiccia, Marina, Gradoni, Luigi, Maroli, Michele“…CONCLUSIONS: Our findings from an old urban focus of leishmaniasis demonstrate that phlebotomine sand flies have adapted fairly well to the drastic environmental changes that have occurred in cities of the Western world in the past century and still represent a potential risk for Leishmania transmission.…”
Publicado 2014
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4309por Carregaro, Vanessa, Ribeiro, José M., Valenzuela, Jesus G., Souza-Júnior, Djalma L., Costa, Diego L., Oliveira, Carlo J. F., Sacramento, Laís A., Nascimento, Manuela S. L., Milanezi, Cristiane M., Cunha, Fernando Q., Silva, João S.“…ADO+AMP mimicked exacerbative effects of P. papatasi saliva in leishmaniasis, increasing parasite burden and cutaneous lesions. …”
Publicado 2015
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4310por Freitas, Elisangela Oliveira, Nico, Dirlei, Guan, Rong, Meyer-Fernandes, José Roberto, Clinch, Keith, Evans, Gary B., Tyler, Peter C., Schramm, Vern L., Palatnik-de-Sousa, Clarisa B.“…Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. …”
Publicado 2015
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4311por da Silva, Raquel Raick P., da Silva, Bruno J. M., Rodrigues, Ana Paula D., Farias, Luis Henrique S., da Silva, Milton N., Alves, Danila Teresa V., Bastos, Gilmara N. T., do Nascimento, José Luiz M., Silva, Edilene O.“…BACKGROUND: Leishmaniasis is an infectious disease caused by various species of the protozoan parasites of the Leishmania genus and transmitted by phlebotomine sandflies. …”
Publicado 2015
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4312por Chouhan, Garima, Islamuddin, Mohammad, Want, Muzamil Y., Ozbak, Hani A., Hemeg, Hassan A., Sahal, Dinkar, Afrin, Farhat“…Visceral leishmaniasis (VL) is a life-threatening protozoal infection chiefly impinging the rural and poor population in the tropical and sub-tropical countries. …”
Publicado 2015
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4313por Chowdhury, Rajib, Kumar, Vijay, Mondal, Dinesh, Das, Murari Lal, Das, Pradeep, Dash, Aditya Prasad, Kroeger, Axel“…BACKGROUND: Visceral leishmaniasis (VL), also known as kala-azar in the Indian sub-continent (ISC), is a major public health concern in Bangladesh, India, and Nepal, where it is caused by Leishmania donovani transmitted by the sand fly Phlebotomus argentipes. …”
Publicado 2016
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4314“…Surprisingly, this inhibitor increased the antileishmanial effect of Sb(III), suggesting that this association might be a valuable strategy for leishmaniasis chemotherapy. CONCLUSION: Our findings represent the first study of NDKb and EF2 genes overexpression that demonstrates an increase of Sb(III) resistance in L. braziliensis which can contribute to develop new strategies for leishmaniasis treatment.…”
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4315por Tirera, Sourakhata, Ginouves, Marine, Donato, Damien, Caballero, Ignacio S., Bouchier, Christiane, Lavergne, Anne, Bourreau, Eliane, Mosnier, Emilie, Vantilcke, Vincent, Couppié, Pierre, Prevot, Ghislaine, Lacoste, Vincent“…(V.) braziliensis isolates obtained from cutaneous leishmaniasis samples identified throughout French Guiana with next-generation sequencing and de novo sequence assembly. …”
Publicado 2017
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4316por dos Santos Silva, Júlia, Caranha, Lindemberg, Moura Santos, Fabrício Kássio, dos Santos, Antonio Pereira, Rodrigues da Silva, Luiz Osvaldo, Ferreira Rangel, Elizabeth“…BACKGROUND: Entomological surveillance of sand fly vectors was carried out to support leishmaniasis prevention and control measures in areas affected by the São Francisco River Transposition Project. …”
Publicado 2017
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4317por Kammoun-Rebai, Wafa, Bahi-Jaber, Narges, Naouar, Ikbel, Toumi, Amine, Ben Salah, Afif, Louzir, Hechmi, Meddeb-Garnaoui, Amel“…Characterizing anti-saliva immune responses in individuals living in well defined leishmaniasis endemic areas would provide valuable insights regarding their effect on parasite transmission and establishment in humans. …”
Publicado 2017
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4318por Terrazas, Cesar, Varikuti, Sanjay, Oghumu, Steve, Steinkamp, Heidi M., Ardic, Nurittin, Kimble, Jennifer, Nakhasi, Hira, Satoskar, Abhay R.“…Ly6C(hi) inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their role in leishmaniasis is unclear. In this study, we report a detrimental role of Ly6C(hi) iMOs in visceral leishmaniasis (VL) caused by Leishmania donovani. …”
Publicado 2017
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4319por Kumar, Vinod, Kumar, Ajay, Das, Sushmita, Kumar, Ashish, Abhishek, Kumar, Verma, Sudha, Mandal, Abhishek, Singh, Rakesh K., Das, Pradeep“…They have also been associated with regulation of immune responses in many human diseases during recent years. Visceral leishmaniasis (VL) is the most severe form of leishmaniasis, which is characterized by impairment of both innate and adaptive immune responses. …”
Publicado 2018
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4320por Eddaikra, Naouel, Ait-Oudhia, Khatima, Kherrachi, Ihcen, Oury, Bruno, Moulti-Mati, Farida, Benikhlef, Razika, Harrat, Zoubir, Sereno, Denis“…In our study, the emergence of S- phenotypes correlates with the inclusion of L. killicki (syn: L. tropica) isolates that cause cutaneous leishmaniasis and that have emerged in Algeria during the last decade. …”
Publicado 2018
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