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4321por Thomaz-Soccol, Vanete, Gonçalves, André Luiz, Piechnik, Claudio Adriano, Baggio, Rafael Antunes, Boeger, Walter Antônio, Buchman, Themis Leão, Michaliszyn, Mario Sergio, Rodrigues dos Santos, Demilson, Celestino, Adão, Aquino, José, Leandro, André de Souza, da Paz, Otacílio Lopes de Souza, Limont, Marcelo, Bisetto, Alceu, Shaw, Jeffrey Jon, Yadon, Zaida Estela, Salomon, Oscar Daniel“…Unfortunately, in recent years an increasing number of autochthonous canine and human visceral leishmaniasis (VL) cases have been reported. The parasite is Leishmania (Leishmania) infantum and it is transmitted by sand flies (Phlebotominae). …”
Publicado 2018
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4322por Dumetz, F., Cuypers, B., Imamura, H., Zander, D., D’Haenens, E., Maes, I., Domagalska, M. A., Clos, J., Dujardin, J.-C., De Muylder, G.“…Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistance dynamics. …”
Publicado 2018
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4323por Marshall, Skye, Kelly, Patrick H., Singh, Brajesh K., Pope, R. Marshall, Kim, Peter, Zhanbolat, Bayan, Wilson, Mary E., Yao, Chaoqun“…Parasites enter a variety of host cells, although a majority are found in macrophages where they replicate intracellularly during chronic leishmaniasis. Symptomatic leishmaniasis causes considerable human morbidity in endemic regions. …”
Publicado 2018
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4324por Rugna, Gianluca, Carra, Elena, Bergamini, Federica, Calzolari, Mattia, Salvatore, Daniela, Corpus, Francesco, Gennari, William, Baldelli, Raffaella, Fabbi, Massimo, Natalini, Silvano, Vitale, Fabrizio, Varani, Stefania, Merialdi, Giuseppe“…BACKGROUND: Visceral leishmaniasis (VL) caused by Leishmania infantum is an ongoing health problem in southern Europe, where dogs are considered the main reservoirs of the disease. …”
Publicado 2018
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4325por Santi, Ana Maria Murta, Lanza, Juliane Sousa, Tunes, Luiza Guimarães, Fiuza, Jacqueline Araújo, Roy, Gaétan, Orfanó, Alessandra da Silva, de Carvalho, Andréa Teixeira, Frézard, Frédéric, Barros, André Luís Branco de, Murta, Silvane Maria Fonseca, do Monte-Neto, Rubens Lima“…There is no safe and efficacious vaccine against human leishmaniasis available and live attenuated vaccines have been used as a prophylactic alternative against the disease. …”
Publicado 2018
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4326por Barbosa, Laiana A., Fiuza, Paloma P., Borges, Letícia J., Rolim, Fellipe A., Andrade, Mayara B., Luz, Nivea F., Quintela-Carvalho, Graziele, Lima, Jonilson B., Almeida, Roque P., Chan, Francis K., Bozza, Marcelo T., Borges, Valeria M., Prates, Deboraci B.“…Recently, necroptosis has emerged as a key component of resistance against pathogens including infected macrophage by Leishmania infantum, the ethiologic agent of Visceral leishmaniasis (VL). VL is the most severe form of Leishmaniasis, characterized by systemic inflammation and neutropenia. …”
Publicado 2018
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4327“…Also, it informs which protein families are unique and conserved within taxon for the choice of taxon-specific biomarkers of vector exposure, as well as those families more conserved across taxa to be used as pan-specific vaccines for leishmaniasis.…”
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4328“…BACKGROUND: Leishmania donovani is a protozoan parasite, a primary causative agent of visceral leishmaniasis. Sterol produced via the mevalonate pathway, show differences in composition across biological kingdoms. …”
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4329por dos-Santos, Júlio Souza, Firmino-Cruz, Luan, Ramos, Tadeu Diniz, da Fonseca-Martins, Alessandra Marcia, Oliveira-Maciel, Diogo, De-Medeiros, Juliana Valente Rodrigues, Chaves, Suzana Passos, Gomes, Daniel Claudio Oliveira, de Matos Guedes, Herbert Leonel“…Leishmaniasis is a complex of neglected diseases caused by parasites of the genus Leishmania, such as Leishmania (Leishmania) amazonensis, the ethiologic agent of diffuse cutaneous leishmaniasis in Brazil. …”
Publicado 2019
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4330por Lima, Isadora S., Solcá, Manuela S., Tafuri, Wagner L., dos-Santos, Washington L. C., de Freitas, Luiz A. R.“…Here, we describe the hepatic alterations observed in dogs with differing clinical manifestations of visceral leishmaniasis in an endemic area in the state of Bahia, Brazil. …”
Publicado 2019
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4331por de Souza, Helen Paredes, de Oliveira, Wanessa Tenório Gonçalves Holanda, dos Santos, Jefferson Pereira Caldas, Toledo, João Paulo, Ferreira, Isis Polianna Silva, de Sousa Esashika, Suely Nilsa Guedes, de Lima, Tatiane Fernandes Portal, de Sousa Delácio, Amanda“…The following incidence rates were mapped: dengue, acute Chagas disease, schistosomiasis, Hansen's disease, hepatitis A, cutaneous leishmaniasis, visceral leishmaniasis, leptospirosis, malaria, and tuberculosis. …”
Publicado 2020
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4332por e Silva, Rafael de Freitas, de Oliveira, Beatriz Coutinho, da Silva, Ailton Alvaro, Brelaz de Castro, Maria Carolina Accioly, Ferreira, Luiz Felipe Gomes Rebello, Hernandes, Marcelo Zaldini, de Brito, Maria Edileuza Felinto, de-Melo-Neto, Osvaldo Pompílio, Rezende, Antônio Mauro, Pereira, Valéria Rêgo Alves“…Background: A safe and effective vaccine against human leishmaniasis still requires the identification of better antigens for immunization and adequate models to evaluate the immune response. …”
Publicado 2020
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4333por Abtahi, Mohsen, Eslami, Gilda, Cavallero, Serena, Vakili, Mahmood, Hosseini, Saeedeh Sadat, Ahmadian, Salman, Boozhmehrani, Mohammad Javad, Khamesipour, Ali“…OBJECTIVE: Leishmaniasis is caused by different Leishmania spp. …”
Publicado 2020
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4334“…Overall in Turkey, 7794 cutaneous leishmaniasis have been reported. IMPLICATIONS: Since the influx of Syrian refugees, there has been an increase in cases of leishmaniasis and measles. …”
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4335por Dvořák, Vít, Tsirigotakis, Nikolaos, Pavlou, Christoforos, Dokianakis, Emmanouil, Akhoundi, Mohammad, Halada, Petr, Volf, Petr, Depaquit, Jérôme, Antoniou, Maria“…BACKGROUND: The Greek island of Crete is endemic for both visceral leishmaniasis (VL) and recently increasing cutaneous leishmaniasis (CL). …”
Publicado 2020
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4336por Karampetsou, Kalliopi, Koutsoni, Olga S., Gogou, Georgia, Angelis, Apostolis, Skaltsounis, Leandros-Alexios, Dotsika, Eleni“…BACKGROUND: Leishmaniasis is a serious multifactorial parasitic disease with limited treatment options. …”
Publicado 2021
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4337por Sangare, Moussa, Coulibaly, Yaya Ibrahim, Huda, Naureen, Vidal, Silvia, Tariq, Sameha, Coulibaly, Michel Emmanuel, Coulibaly, Siaka Yamoussa, Soumaoro, Lamine, Dicko, Ilo, Traore, Bourama, Sissoko, Ibrahim Moussa, Traore, Sekou Fantamady, Faye, Ousmane, Nutman, Thomas B., Valenzuela, Jesus G., Oliveira, Fabiano, Doumbia, Seydou, Kamhawi, Shaden, Semnani, Roshanak Tolouei“…BACKGROUND: In Mali, cutaneous leishmaniasis (CL) and filariasis are co-endemic. Previous studies in animal models of infection have shown that sand fly saliva enhance infectivity of Leishmania parasites in naïve hosts while saliva-specific adaptive immune responses may protect against cutaneous and visceral leishmaniasis. …”
Publicado 2021
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4338por Gutiérrez-Corbo, Camino, Domínguez-Asenjo, Bárbara, Martínez-Valladares, María, Pérez-Pertejo, Yolanda, García-Estrada, Carlos, Balaña-Fouce, Rafael, Reguera, Rosa M.“…ABSTRACT: Diseases caused by trypanosomatids (Sleeping sickness, Chagas disease, and leishmaniasis) are a serious public health concern in low-income endemic countries. …”
Publicado 2021
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4339por da Fonseca-Martins, Alessandra M., de Souza Lima-Gomes, Phillipe, Antunes, Maísa Mota, de Moura, Renan Garcia, Covre, Luciana P., Calôba, Carolina, Rocha, Vivian Grizente, Pereira, Renata M., Menezes, Gustavo Batista, Gomes, Daniel Claudio Oliveira, Saraiva, Elvira M., de Matos Guedes, Herbert L.“…Neutrophils play an important role in the outcome of leishmaniasis, contributing either to exacerbating or controlling the progression of infection, a dual effect whose underlying mechanisms are not clear. …”
Publicado 2021
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4340“…Pathophysiology of visceral leishmaniasis (VL) is not fully understood and it has been widely accepted that the parasitic components and host immune response both contribute to the perpetuation of the disease. …”
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