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4381por Monteiro, Carolina Cunha, Villegas, Luis Eduardo Martinez, Campolina, Thais Bonifácio, Pires, Ana Clara Machado Araújo, Miranda, Jose Carlos, Pimenta, Paulo Filemon Paolucci, Secundino, Nagila Francinete Costa“…BACKGROUND: Parasites of the genus Leishmania cause a broad spectrum of diseases, collectively known as leishmaniasis, in humans worldwide. American cutaneous leishmaniasis is a neglected disease transmitted by sand fly vectors including Lutzomyia intermedia, a proven vector. …”
Publicado 2016
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4382por Pratti, Juliana Elena Silveira, Ramos, Tadeu Diniz, Pereira, Joyce Carvalho, da Fonseca-Martins, Alessandra Marcia, Maciel-Oliveira, Diogo, Oliveira-Silva, Gabriel, de Mello, Mirian França, Chaves, Suzana Passos, Gomes, Daniel Claudio Oliveira, Diaz, Bruno Lourenço, Rossi-Bergmann, Bartira, de Matos Guedes, Herbert Leonel“…BACKGROUND: We have previously demonstrated that intranasal vaccination of highly susceptible BALB/c mice with whole Leishmania amazonensis antigens (LaAg) leads to protection against murine cutaneous leishmaniasis. Here, we evaluate the response of partially resistant C57BL/6 mice to vaccination as a more representative experimental model of human cutaneous leishmaniasis. …”
Publicado 2016
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4383por Deep, Deepak Kumar, Singh, Ruchi, Bhandari, Vasundhra, Verma, Aditya, Sharma, Vanila, Wajid, Saima, Sundar, Shyam, Ramesh, V., Dujardin, Jean Claude, Salotra, Poonam“…BACKGROUND: Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). …”
Publicado 2017
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4384por Akinsolu, Folahanmi Tomiwa, de Paiva, Vitor Nobre, Souza, Samuel Santos, Varga, Orsolya“…Governmental institutions and universities are the primary original assignees. Among the NTDs, leishmaniasis, dengue, and rabies received the highest number of patent families, while human African trypanosomiasis (sleeping sickness), taeniasis, and dracunciliasis received the least. …”
Publicado 2017
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4385por Awadh Ali, Nasser A., Al Sokari, Saeed Salah, Gushash, Ahmed, Anwar, Sirajudheen, Al-Karani, Khalid, Al-Khulaidi, Abdulwali“…Maximum number of species (23 species) was used for treating skin diseases (42.6%) including leishmaniasis, wound healing, dermatitis, psoriasis, vitiligo and warts. …”
Publicado 2017
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4386por Jaiswal, Priyank, Datta, Souvik, Sardar, Bikash, Chaudhuri, Surya Jyoti, Maji, Dipankar, Ghosh, Manab, Saha, Bibhuti, Mukhopadhyay, Sumi“…BACKGROUND: Post Kala Azar Dermal Leishmaniasis (PKDL) occurs as dermal consequence of previous Visceral Leishmaniasis (VL) infection and serves as an important reservoir for transmission of VL. …”
Publicado 2018
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4387por Messlinger, Helena, Sebald, Heidi, Heger, Lukas, Dudziak, Diana, Bogdan, Christian, Schleicher, Ulrike“…In contrast to experimental murine leishmaniasis, the human NK cell response to Leishmania is still poorly characterized. …”
Publicado 2018
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4388por Grecco, Simone S, Costa-Silva, Thais A, Sousa, Fernanda S, Cargnelutti, Stefano B, Umehara, Eric, Mendonça, Poliana S, Tempone, Andre G, Lago, Joao Henrique G“…BACKGROUND: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). …”
Publicado 2018
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4389por Giraud, Emilie, Rouault, Eline, Fiette, Laurence, Colle, Jean-Hervé, Smirlis, Despoina, Melanitou, Evie“…BACKGROUND: Leishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). …”
Publicado 2019
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4390por Bezerra, Izabella Pereira da Silva, Oliveira-Silva, Gabriel, Braga, Danielle Sophia Ferreira Santos, de Mello, Mirian França, Pratti, Juliana Elena Silveira, Pereira, Joyce Carvalho, da Fonseca-Martins, Alessandra Marcia, Firmino-Cruz, Luan, Maciel-Oliveira, Diogo, Ramos, Tadeu Diniz, Vale, André Macedo, Gomes, Daniel Claudio Oliveira, Rossi-Bergmann, Bartira, de Matos Guedes, Herbert Leonel“…Leishmania (Leishmania) amazonensis is endemic in South America and causes cutaneous leishmaniasis (CL), which can evolve into a diffuse form, characterized by an anergic immune response. …”
Publicado 2019
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4391por Bobbio, Flavio, Di Gennaro, Francesco, Marotta, Claudia, Kok, John, Akec, Gabriel, Norbis, Luca, Monno, Laura, Saracino, Annalisa, Mazzucco, Walter, Lunardi, Marta“…A k39 antigen test for visceral leishmaniasis was also performed on patients with lymphadenopathy and/or splenomegaly. …”
Publicado 2019
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4392por Cazan, Cristina Daniela, Păstrav, Ioana Raluca, Ionică, Angela Monica, Oguz, Gizem, Erisoz Kasap, Ozge, Dvorak, Vit, Halada, Petr, Dumitrache, Mirabela Oana, Volf, Petr, Alten, Bulent, Mihalca, Andrei Daniel“…BACKGROUND: Phlebotomine sand flies (Diptera: Psychodidae) are haematophagous insects that transmit the protozoan parasite Leishmania infantum (Kinetoplastida: Trypanosomatidae), the main causative agent of both zoonotic visceral leishmaniasis (VL) and canine leishmaniasis (CanL) in the Mediterranean basin. …”
Publicado 2019
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4393“…BACKGROUND: Leishmaniasis is a vector-borne disease, caused by the infection of Leishmania parasites which are transmitted by the bite of infected female phlebotomine sand flies. …”
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4394por Cheghabalaki, Zahra Zarei, Yarahmadi, Dariush, Karampour, Mostafa, Shamsipour, Aliakbar“…BACKGROUND: Phlebotomine (Ph.) sand flies are the vectors of different types of leishmaniasis and arboviruses to humans. Variations in climate conditions could lead to changes in the dynamics of zoonotic cutaneous leishmaniasis (ZCL) and its agents, such as Ph. sand flies and reservoirs. …”
Publicado 2019
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4395por Rigoni, Thaís S., Vellozo, Natália S., Cabral-Piccin, Mariela, Fabiano-Coelho, Laryssa, Lopes, Ulisses G., Filardy, Alessandra A., DosReis, George A., Lopes, Marcela F.“…Macrophages host Leishmania major infection, which causes cutaneous Leishmaniasis in humans. In the murine model, resistance to infection depends on the host immunity mediated by CD4 T-cell cytokines and macrophages. …”
Publicado 2020
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4396por Pinto, Erika Gracielle, Barbosa, Leandro R.S., Mortara, Renato A., Tempone, Andre Gustavo“…Leishmaniasis is a parasitic neglected tropical disease and result in a broad spectrum of clinical manifestations, ranging from a single ulceration to a progressive and fatal visceral disease. …”
Publicado 2020
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4397“…Sodium stibogluconate (Pentostam® (1)), for treatment of certain presentations of cutaneous, visceral, and mucocutaneous leishmaniasis, accounted for 6–22% of annual releases over the last 10 years. …”
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4398AgNP-PVP-meglumine antimoniate nanocomposite reduces Leishmania amazonensis infection in macrophagespor Gélvez, Ana Patricia Cacua, Diniz Junior, José Antonio Picanço, Brígida, Rebecca Thereza Silva Santa, Rodrigues, Ana Paula Drummond“…BACKGROUND: Leishmaniasis is an infectious disease caused by parasites of the genus Leishmania and presents different clinical manifestations. …”
Publicado 2021
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4399por Want, Muzamil Yaqub, Yadav, Priya, Khan, Rakin, Chouhan, Garima, Islamuddin, Mohammad, Aloyouni, Sheka Yagub, Chattopadhyay, Asoke P, AlOmar, Suliman Yousef, Afrin, Farhat“…INTRODUCTION: The current therapeutic armory for visceral leishmaniasis (VL) caused by Leishmania donovani complex is inadequate, coupled with serious limitations. …”
Publicado 2021
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4400por Gonçalves, Gustavo, Campos, Monique Paiva, Gonçalves, Alessandra Silva, Medeiros, Lia Carolina Soares, Figueiredo, Fabiano Borges“…BACKGROUND: Leishmania infantum is the most important etiological agent of visceral leishmaniasis in the Americas and Mediterranean region, and the dog is the main host. …”
Publicado 2021
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