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4421“…Five important diseases such as leptospirosis, dengue, chikungunya, Japanese encephalitis, and leishmaniasis have been discussed in this article.…”
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4422por Leaver, David J.“…SDM has been demonstrated to be a valid drug target for antiprotozoal therapies, and much research has been focused on using SDM inhibitors to treat neglected tropical diseases such as human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis. Sterol C24-methyltransferase (24-SMT) introduces the C24-methyl group of ergosterol and is an enzyme found in pathogenic fungi and protozoa but is absent from animals. …”
Publicado 2018
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4423por Barea, Carlos, Pabón, Adriana, Galiano, Silvia, Pérez-Silanes, Silvia, Gonzalez, German, Deyssard, Chloe, Monge, Antonio, Deharo, Eric, Aldana, Ignacio“…Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. …”
Publicado 2012
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4424por Pisarski, Konrad“…In line with WHO analyses of NTDs, intestinal nematode infections, leishmaniasis, schistosomiasis, and lymphatic filariasis should be prioritised, as well as the burden of disease of cryptosporidiosis, which is largely underestimated. …”
Publicado 2019
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4425por Kleschenko, Yuliya, Grybchuk, Danyil, Matveeva, Nadezhda S., Macedo, Diego H., Ponirovsky, Evgeny N., Lukashev, Alexander N., Yurchenko, Vyacheslav“…Here we report sequence and phylogenetic analysis of two new isolates of Leishmania RNA virus 2 (LRV2) found in Leishmania major isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations. …”
Publicado 2019
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4426“…In this review, we have compiled the latest information (2012–2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs.…”
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4427por de Lima, Janaína Paolucci Sales, Pinheiro, Maria Lúcia Belém, Allaman, Ivan Bezerra, Silva-Jardim, Izaltina“…INTRODUCTION: Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem. …”
Publicado 2020
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4428por Silva, Rafael C. M. C., Travassos, Leonardo H., Paiva, Claudia N., Bozza, Marcelo T.“…In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.…”
Publicado 2020
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4429por Bhattacharya, Arijit, Corbeil, Audrey, do Monte-Neto, Rubens L., Fernandez-Prada, Christopher“…Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by trypanosomatid parasites. …”
Publicado 2020
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4430“…Visceral leishmaniasis (VL) causes extensive splenic pathology that contributes to dysfunctional immune responses, in part through displacement and destruction of cell populations involved in maintaining splenic structural integrity. …”
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4431Insights into Leishmania Molecules and Their Potential Contribution to the Virulence of the Parasite“…Among other parasitic diseases, leishmaniasis remains an important public health problem caused by the protozoa of the genus Leishmania, transmitted by the bite of the female sand fly. …”
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4432“…Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that traditionally have shown multiple health benefits and are known for their anti-cancer, anti-inflammatory, anti-bacterial, anti-leishmaniasis, and many other medicinal properties. Structures of these withanolides possess a few reactive sites that can be exploited to design and synthesize more potent and safe analogs. …”
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4433por Squarre, David, Chambaro, Herman M., Hayashida, Kyoko, Moonga, Lavel C., Qiu, Yongjin, Goto, Yasuyuki, Oparaocha, Elizabeth, Mumba, Chisoni, Muleya, Walter, Bwalya, Patricia, Chizimu, Joseph, Chembensofu, Mwelwa, Simulundu, Edgar, Mwasinga, Wizaso, Banda, Nelly, Mwenda, Racheal, Yamagishi, Junya, Nalubamba, King S., Banda, Fredrick, Munyeme, Musso, Sawa, Hirofumi, Fandamu, Paul“…Our findings suggest presence of and probable emergence of leishmaniasis in Zambia, indicating the need for physicians and veterinarians to consider the disease during diagnosis.…”
Publicado 2022
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4434por Cárcano, Cristiane Botelho Miranda, Tanaka, Vanessa D.’Andretta, Alessi, Cristina, Reis, Monise Tadin, Ferreira, Mariana Soares“…The clinical presentation of paracoccidioidomycosis is diverse, and the sarcoid-like form can mimic several chronic granulomatous diseases, such as sarcoidosis, tuberculoid leprosy, leishmaniasis, or tuberculosis. This presentation of cutaneous paracoccidioidomycosis is rare, and its diagnosis depends on the clinicopathological correlation, which can be a challenge for the dermatologist.…”
Publicado 2022
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4435“…Sporotrichoid‐lymphocutaneous‐pattern is classically seen in sporotrichosis, though also present in other infections like atypical mycobacteriosis and leishmaniasis. Cutaneous atypical mycobacterial infection presents as localized lesions in immunocompetent and is widespread in immunosuppressed patients. …”
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4436por de Oliveira Mendes-Aguiar, Carolina, do Monte Alves, Manoella, de Albuquerque Lopes Machado, Amanda, de Góis Monteiro, Glória Regina, Medeiros, Iara Marques, Queiroz, Jose Wilton, Lima, Iraci Duarte, Pearson, Richard D., Wilson, Mary E., Glesby, Marshall J., do Nascimento, Eliana Lúcia Tomaz, Jerônimo, Selma Maria Bezerra“…An immunocompromised state increases the risk of converting asymptomatic infection to symptomatic visceral leishmaniasis (VL), which has a ~5% fatality rate even with treatment. …”
Publicado 2023
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4437Identification of key genes and pathways in atherosclerosis using integrated bioinformatics analysispor Li, Shihuan, Li, Suqin, Li, Qingjie, Zhou, Qiaofeng, Liao, Wenli, Yu, Liangzhu, Ouyang, Changhan, Xia, Hongli, Liu, Chao, Li, Mincai“…CONCLUSIONS: Our data showed the pathway of Osteoclast differentiation and Leishmaniasis was involved in the AS process and we developed a three-gene model base on the prognosis of AS. …”
Publicado 2023
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4438por Oliveira, Simone S. C., Correia, Claudyane A., Santos, Vanessa S., da Cunha, Elaine F. F., de Castro, Alexandre A., Ramalho, Teodorico C., Devereux, Michael, McCann, Malachy, Branquinha, Marta H., Santos, André L. S.“…Leishmaniasis, caused by protozoa of the genus Leishmania, encompasses a group of neglected diseases with diverse clinical and epidemiological manifestations that can be fatal if not adequately and promptly managed/treated. …”
Publicado 2023
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4439por Temeyer, Kevin B, Brake, Danett K, Tuckow, Alexander P, Li, Andrew Y, Pérez deLeón, Adalberto A“…Zoonotic cutaneous leishmaniasis caused by L. major is vectored mainly by Phlebotomus papatasi (Scopoli) in Asia and Africa. …”
Publicado 2013
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4440por Ziakas, Panayiotis D., Prodromou, Michael L., El Khoury, Joseph, Zintzaras, Elias, Mylonakis, Eleftherios“…TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). …”
Publicado 2013
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