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4441por Efstathiou, Antonia, Gaboriaud-Kolar, Nicolas, Smirlis, Despina, Myrianthopoulos, Vassilios, Vougogiannopoulou, Konstantina, Alexandratos, Alexandros, Kritsanida, Marina, Mikros, Emmanuel, Soteriadou, Ketty, Skaltsounis, Alexios-Leandros“…CONCLUSIONS: In conclusion, 3'-bulky amino substituted 6-BIO derivatives, which demonstrate enhanced specificity towards LGSK-3, represent a new scaffold for targeted drug development to treat leishmaniasis.…”
Publicado 2014
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4442por Halliday, Alice, Turner, Joseph D., Guimarães, Ana, Bates, Paul A., Taylor, Mark J.“…TLR2 plays a role in parasite recognition and activation of immune responses during cutaneous leishmaniasis infection, suggesting that TLR2 could be targeted by adjuvants for use in Leishmania vaccines. …”
Publicado 2016
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4443por Hosseini-Vasoukolaei, Nasibeh, Idali, Farah, Khamesipour, Ali, Yaghoobi-Ershadi, Mohammad Reza, Kamhawi, Shaden, Valenzuela, Jesus G., Edalatkhah, Haleh, Arandian, Mohammad Hossein, Mirhendi, Hossein, Emami, Shaghayegh, Jafari, Reza, Saeidi, Zahra, Jeddi-Tehrani, Mahmood, Akhavan, Amir Ahmad“…Cutaneous and visceral leishmaniasis are of public health importance in many parts of Iran and neighbouring countries where P. papatasi is the proven and dominant sand fly vector for ZCL, the most prevalent and endemic form of the disease in Iran. …”
Publicado 2016
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4444“…CRISPR-Cas9-mediated genome editing has recently been adapted for Leishmania spp. parasites, the causative agents of human leishmaniasis. We have optimized this genome-editing tool by selecting for cells with CRISPR-Cas9 activity through cotargeting the miltefosine transporter gene; mutation of this gene leads to miltefosine resistance. …”
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4445por Alves-Silva, Marcus Vinícius, Nico, Dirlei, Morrot, Alexandre, Palatnik, Marcos, Palatnik-de-Sousa, Clarisa B.“…In mice, the NH36 induced protection against visceral leishmaniasis is mediated by a CD4+ T cell response against its C-terminal domain (F3). …”
Publicado 2017
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4446por Vellozo, Natália S., Pereira-Marques, Sâmara T., Cabral-Piccin, Mariela P., Filardy, Alessandra A., Ribeiro-Gomes, Flávia L., Rigoni, Thaís S., DosReis, George A., Lopes, Marcela F.“…Resistance to Leishmaniasis depends on Leishmania species, mouse strain, and both innate and adaptive immunity. …”
Publicado 2017
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4447“…BACKGROUND: Recent reports showed high numbers of visceral leishmaniasis cases in North Darfur, western Sudan. Due to a lack of previous studies, no information is available on local transmission of the disease in these areas. …”
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4448por Coulibaly, Cheick Amadou, Traore, Bourama, Dicko, Adama, Samake, Sibiry, Sissoko, Ibrahim, Anderson, Jennifer M., Valenzuela, Jesus, Traore, Sekou F., Faye, Ousmane, Kamhawi, Shaden, Oliveira, Fabiano, Doumbia, Seydou“…BACKGROUND: Cutaneous leishmaniasis (CL) is an endemic neglected tropical disease prevalent in several areas where seasonal malaria transmission is active. …”
Publicado 2018
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4449por Osorio, Lyda, Garcia, Jonny Alejandro, Parra, Luis Gabriel, Garcia, Victor, Torres, Laura, Degroote, Stéphanie, Ridde, Valéry“…Fewer studies, assessing mainly performance, were identified for visceral leishmaniasis (n = 9), filariasis and leptospirosis (each n = 5), enteric fever and schistosomiasis (each n = 3), dengue and leprosy (each n = 2), and Chagas disease, human African trypanosomiasis, and cholera (each n = 1). …”
Publicado 2018
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4450por Petersen, Antonio Luis de Oliveira Almeida, Campos, Thiers A., Dantas, Diana Angélica dos Santos, Rebouças, Juliana de Souza, da Silva, Juliana Cruz, de Menezes, Juliana P. B., Formiga, Fábio R., de Melo, Janaina V., Machado, Giovanna, Veras, Patrícia S. T.“…The current long-term treatment for leishmaniasis causes severe side effects and resistance in some cases. …”
Publicado 2018
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4451por Ceccarelli, Marcello, Diotallevi, Aurora, Andreoni, Francesca, Vitale, Fabrizio, Galluzzi, Luca, Magnani, Mauro“…BACKGROUND: Leishmania infantum is the aetiological agent of visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). …”
Publicado 2018
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4452por Menghistu, Habtamu Taddele, Hailu, Kassahun Tadesse, Shumye, Nigus Abebe, Redda, Yisehak Tsegaye“…The incidence proportion of visceral leishmaniasis per 100,000 population was 4.1, 1.3 and 1.2 cases for Ab’Ala, Gubalafto and Weldiya, and Raya Azebo districts, respectively. …”
Publicado 2018
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4453por da Silva Gonçalves, Daniela, Iturbe-Ormaetxe, Iñaki, Martins-da-Silva, Andrea, Telleria, Erich Loza, Rocha, Marcele Neves, Traub-Csekö, Yara M., O’Neill, Scott L., Sant’Anna, Maurício Roberto Viana, Moreira, Luciano Andrade“…BACKGROUND: The leishmaniases are important neglected diseases caused by Leishmania spp. which are transmitted by sand flies, Lutzomyia longipalpis being the main vector of visceral leishmaniasis in the Americas. The methodologies for leishmaniasis control are not efficient, causing 1.5 million reported cases annually worldwide, therefore showing the need for development of novel strategies and interventions to control transmission of the disease. …”
Publicado 2019
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4454por Pratti, Juliana Elena Silveira, da Fonseca Martins, Alessandra Marcia, da Silva, Juliana Paiva, Ramos, Tadeu Diniz, Pereira, Joyce Carvalho, Firmino-Cruz, Luan, Oliveira-Maciel, Diogo, Vieira, Thiago Soares de Souza, Lacerda, Leandra Linhares, Vale, Andre Macedo, Freire-de-Lima, Celio G., Gomes, Daniel C. Oliveira, Saraiva, Elvira M., Rossi-Bergmann, Bartira, de Matos Guedes, Herbert Leonel“…Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis (CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis, although several vaccine preparations are in experimental stages. …”
Publicado 2019
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4455por Antonia, Alejandro L., Gibbs, Kyle D., Trahair, Esme D., Pittman, Kelly J., Martin, Amelia T., Schott, Benjamin H., Smith, Jeffrey S., Rajagopal, Sudarshan, Thompson, J. Will, Reinhardt, Richard Lee, Ko, Dennis C.“…Cutaneous leishmaniasis results in disfiguring skin lesions if the host immune system does not appropriately respond to infection. …”
Publicado 2019
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4456por Remadi, Latifa, Chargui, Najla, Jiménez, Maribel, Molina, Ricardo, Haouas, Najoua, González, Estela, Chaabane-Banaouas, Raja, Ben Salah, Eya, Haddaji, Mohsen, Chaabouni, Yassine, Babba, Hamouda“…METHODOLOGY AND FINDINGS: A total of 3,831 sand flies were collected in seven locations from the center of Tunisia affected by human visceral leishmaniasis. The collected sand flies belonged to two genus Phlebotomus (Ph.) …”
Publicado 2020
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4457por Cavalera, Maria Alfonsa, Iatta, Roberta, Laricchiuta, Pietro, Passantino, Giuseppe, Abramo, Francesca, Mendoza-Roldan, Jairo Alfonso, Otranto, Domenico, Zatelli, Andrea“…RESULTS: Tigers either L. infantum-positive (group A) or -negative (group B) were apparently healthy or presented visceral leishmaniasis unrelated conditions, except for one animal in which a large non-healing cutaneous lesion was observed. …”
Publicado 2020
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4458por Chen, Han-Ming, Chen, Hui-Ying, Tao, Feng, Gao, Jing-Peng, Li, Kai-Li, Shi, Hua, Peng, Heng, Ma, Ya-Jun“…BACKGROUND: Visceral leishmaniasis (VL) was one of the most important parasitic diseases in China, caused by Leishmania protozoans and transmitted by sand flies. …”
Publicado 2020
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4459por Rebouças-Silva, Jéssica, Tadini, Maraine Catarina, Devequi-Nunes, Danielle, Mansur, Ana Luíza, S Silveira-Mattos, Paulo, I de Oliveira, Camila, R Formiga, Fábio, Berretta, Andresa A, Marquele-Oliveira, Franciane, Borges, Valéria M“…BACKGROUND: Leishmaniasis is a neglected disease, and the current therapeutic arsenal for its treatment is seriously limited by high cost and toxicity. …”
Publicado 2020
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4460por Rigg, Chystrie A., Perea, Milixa, González, Kadir, Saldaña, Azael, Calzada, José E., Gao, Yan, Gottdenker, Nicole L., Chaves, Luis Fernando“…ABSTRACT: Cutaneous Leishmaniasis transmission in the New World is observed in areas with rich sand fly species’ faunas. …”
Publicado 2021
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