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4501por Akhoundi, Mohammad, Sereno, Denis, Marteau, Anthony, Bruel, Christiane, Izri, Arezki“…Arthropod blood feeders are vectors of several human pathogenic agents, including viruses (e.g., yellow fever, chikungunya, dengue fever), parasites (e.g., malaria, leishmaniasis, lymphatic filariasis), or bacteria (e.g., plague). …”
Publicado 2020
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4502por Antinarelli, Luciana Maria Ribeiro, de Souza, Marcus Vinicius Nora, Coelho, Eduardo Antonio Ferraz, Lima, Wallace Pacienza, Coimbra, Elaine Soares“…INTRODUCTION: The drugs currently available for leishmaniasis treatment have major limitations. METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. …”
Publicado 2020
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4503por Van den Kerkhof, Magali, Sterckx, Yann G.-J., Leprohon, Philippe, Maes, Louis, Caljon, Guy“…Kinetoplastids are the causative agents of leishmaniasis, human African trypanosomiasis, and American trypanosomiasis. …”
Publicado 2020
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4504por Kontogiannidou, Eleni, Meikopoulos, Thomas, Gika, Helen, Panteris, Emmanuel, Vizirianakis, Ioannis S., Müllertz, Anette, Fatouros, Dimitrios G.“…Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. …”
Publicado 2020
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4505por Hong, Ahyun, Zampieri, Ricardo Andrade, Shaw, Jeffrey Jon, Floeter-Winter, Lucile Maria, Laranjeira-Silva, Maria Fernanda“…There are various clinical manifestations, ranging from self-healing cutaneous lesions to potentially fatal visceral leishmaniasis, all of which are associated with different Leishmania species. …”
Publicado 2020
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4506“…Nitroaromatic antibiotics show activity against anaerobic bacteria and parasites, finding use in the treatment of Heliobacter pylori infections, tuberculosis, trichomoniasis, human African trypanosomiasis, Chagas disease and leishmaniasis. Despite this activity and a clear need for the development of new treatments for these conditions, the associated toxicity and lack of clear mechanisms of action have limited their therapeutic development. …”
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4507“…We present case reports of two patients treated with miltefosine for mucocutaneous leishmaniasis whose gastrointestinal symptoms were initially diagnosed as a drug reaction and only later recognized as due to COVID-19. …”
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4508por Zilberstein, Dan“…Phagolysosomes of macrophages are the niche where the parasitic protozoan Leishmania resides and causes human leishmaniasis. During infection, this organism encounters dramatic environmental changes. …”
Publicado 2021
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4509por Zhang, Zhen, Ray, Sneha, Imlay, Leah, Callaghan, Lauren T., Niederstrasser, Hanspeter, Mallipeddi, Prema Latha, Posner, Bruce A., Wetzel, Dawn M., Phillips, Margaret A., Smith, Myles W.“…Scalable access to spiroindimicins A, H, and their congeners has enabled discovery of their activity against several parasites relevant to human health, providing potential starting points for new therapeutics for the neglected tropical diseases leishmaniasis and African sleeping sickness.…”
Publicado 2021
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4510por Rosa, Fernanda Andreia, Mendes de Souza Melo, Samara, Pianoski, Karlos Eduardo, Poletto, Julia, dos Santos, Mariellen Guilherme, Vieira da Silva, Michael Jackson, Lazarin‐Bidóia, Danielle, Volpato, Hélito, Moura, Sidnei, Nakamura, Celso Vataru“…A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas disease, respectively. Thirteen compounds exhibited a selective index greater than 10. …”
Publicado 2021
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4511“…In this review, we describe the strategies and pharmacophores that have been used in developing proteasome inhibitors with potency and selectivity that spare human proteasomes and highlight the development of clinical proteasome inhibitor candidates for treatment of leishmaniasis and Chagas disease. Finally, we discuss the future challenges and therapeutical potentials of the microbial proteasome inhibitors.…”
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4512por Chadha, Sanya, Mallampudi, N. Arjunreddy, Mohapatra, Debendra K., Madhubala, Rentala“…Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis. Increasing resistance and severe side effects of existing drugs have led to the need to identify new chemotherapeutic targets. …”
Publicado 2017
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4513“…BACKGROUND: Indoor residual spraying (IRS) is the mainstay for vector control intervention of visceral leishmaniasis (VL) in India. Little is known on the control effects of IRS on different household types. …”
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4514por Georgiadou, Sarah, Gatselis, Nikolaos K, Stefos, Aggelos, Zachou, Kalliopi, Makaritsis, Konstantinos, Rigopoulou, Eirini I, Dalekos, George N“…Underlying infections were diagnosed in 59 patients (74%) as follows: leishmaniasis alone in 15/80 (18.9%), leishmaniasis concurrently with Coxiella Burnetti or non-Hodgkin lymphoma in 2/80 (2.5%), bacterial infections in 14/80 (17.5%) including one case with concurrent non-Hodgkin lymphoma, viral infections in 13/80 (16.3%), fungal infections in 2/80 (2.5%), infections by mycobacteria in 1/80 (1.3%) and unidentified pathogens in 12/80 (15%). …”
Publicado 2019
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4515por Hurdayal, Ramona, Nieuwenhuizen, Natalie Eva, Khutlang, Rethabile, Brombacher, Frank“…Leishmaniasis is a vector-borne disease caused by Leishmania parasites. …”
Publicado 2020
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4516por Costa, Natalia C. S., Piccoli, Julia P., Santos-Filho, Norival A., Clementino, Leandro C., Fusco-Almeida, Ana M., De Annunzio, Sarah R., Fontana, Carla R., Verga, Juliane B. M., Eto, Silas F., Pizauro-Junior, João M., Graminha, Marcia A. S., Cilli, Eduardo M.“…Among the major parasitic diseases, Leishmaniasis figures as an urgent challenge due to its high incidence and severity. …”
Publicado 2020
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4517por Andrade, Juvana Moreira, Gonçalves, Leilane Oliveira, Liarte, Daniel Barbosa, Lima, Davi Alvarenga, Guimarães, Frederico Gonçalves, de Melo Resende, Daniela, Santi, Ana Maria Murta, de Oliveira, Luciana Marcia, Velloso, João Paulo Linhares, Delfino, Renato Guimarães, Pescher, Pascale, Späth, Gerald F., Ruiz, Jeronimo Conceição, Murta, Silvane Maria Fonseca“…BACKGROUND: One of the major challenges to leishmaniasis treatment is the emergence of parasites resistant to antimony. …”
Publicado 2020
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4518por Pinheiro, Marcos Paulo Gomes, Silva-Inacio, Cássio Lázaro, Silva, Marcel Miranda de Medeiros, Araújo, Paulo Sérgio Fagundes de, Ximenes, Maria de Fátima Freire de Melo“…BACKGROUND: Phlebotomines are a group of insects which include vectors of the Leishmania parasites that cause visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL), diseases primarily affecting populations of low socioeconomic status. …”
Publicado 2021
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4519por Carrion, Carme, Robles, Noemí, Sola-Morales, Oriol, Aymerich, Marta, Ruiz Postigo, Jose Antonio“…Six of the 13 (46%) studies were community-based cross-sectional studies intended to epidemiologically map a specific disease, mainly lymphatic filariasis, but also cutaneous leishmaniasis, leprosy, and NTDs, as well as sNTDs in general. …”
Publicado 2020
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4520por Michelutti, Alice, Toniolo, Federica, Bertola, Michela, Grillini, Marika, Simonato, Giulia, Ravagnan, Silvia, Montarsi, Fabrizio“…BACKGROUND: Recent climate and environmental changes have resulted in the geographical expansion of Mediterranean Leishmania infantum vectors towards northern latitudes and higher altitudes in different European countries, including Italy, where new foci of canine leishmaniasis have been observed in the northern part of the country. …”
Publicado 2021
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