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4661por Loiseau, Philippe M., Balaraman, Kaluvu, Barratt, Gillian, Pomel, Sébastien, Durand, Rémy, Frézard, Frédéric, Figadère, Bruno“…There is a need for new, cost-effective drugs to treat leishmaniasis. A strategy based on traditional medicine practiced in Bolivia led to the discovery of the 2-substituted quinoline series as a source of molecules with antileishmanial activity and low toxicity. …”
Publicado 2022
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4662“…Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the genus Leishmania. …”
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4663“…CASE PRESENTATION: We present four cases of secondary HLH, highlighting the demographic and clinical characteristics of these patients, underlying triggers (including systemic lupus erythematosus, lymphoproliferative disorders, and leishmaniasis), together with challenges associated with the diagnosis and treatment of this rare disorder and a brief review of literature. …”
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4664“…Filariae-derived immunosuppression can also be exploited to treat other inflammatory diseases and immunopathologic states of parasitic diseases, such as cerebral malaria, and to prevent leishmaniasis. This paper reviews immunomodulatory mechanisms acquired by these filariae for their own survival and their potential application in the development of novel therapeutic approaches against parasitic and inflammatory diseases. …”
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4665por Santini, María Soledad, Cavia, Regino, Quintana, María Gabriela, Acosta, Mariana Manteca, Salomón, Oscar Daniel“…Our study defines the ‘where’ and ‘when’ implement the actions to mitigate leishmaniasis cases.…”
Publicado 2022
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4666por Limon, Anne-Claire D., Patabendige, Hiran M. L. W., Azhari, Ala, Sun, Xingmin, Kyle, Dennis E., Wilson, Nerida G., Baker, Bill J.“…Alcyosterone (5) and several alcyopterosins were similarly potent against the protist Leishmania donovani, the causative agent of leishmaniasis, a disfiguring disease that can be fatal if not treated. …”
Publicado 2022
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4667por Hall, Amy V., Gostick, Isobel E. F., Yufit, Dmitry S., Marchant, Gloria Y., Kirubakaran, Preyanthiny, Madu, Shadrack J., Li, Mingzhong, Steel, Patrick G., Steed, Jonathan W.“…[Image: see text] Miltefosine is a repurposed anticancer drug and currently the only orally administered drug approved to treat the neglected tropical disease leishmaniasis. Miltefosine is hygroscopic and must be stored at subzero temperatures. …”
Publicado 2022
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4668por Rodrigues, Maria João, Pereira, Catarina Guerreiro, Oliveira, Marta, Zengin, Gökhan, Custódio, Luísa“…Parasitic diseases, especially those caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, and lymphatic filariasis, are the cause of millions of morbidities and deaths every year, mainly in tropical regions. …”
Publicado 2023
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4669por Buffi, Gloria, Ceccarelli, Marcello, Diotallevi, Aurora, Abruzzese, Michelalberto, Bruno, Federica, Castelli, Germano, Vitale, Fabrizio, Andreoni, Francesca, Bencardino, Daniela, Magnani, Mauro, Galluzzi, Luca“…BACKGROUND: Leishmaniasis is a zoonotic disease endemic in the Mediterranean region where Leishmania infantum is the causative agent of human and canine infection. …”
Publicado 2023
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4670por de Moraes, Laise, Santos, Luciane Amorim, Arruda, Liã Bárbara, da Silva, Maria da Purificação Pereira, Silva, Márcio de Oliveira, Silva, José Adriano Góes, Ramos, André, dos Santos, Marcos Bastos, Torres, Felipe Guimarães, Orge, Cibele, Teixeira, Antonio Marcos dos Santos, Vieira, Thiago Santos, Ramírez, Laura, Soto, Manuel, Grassi, Maria Fernanda Rios, de Siqueira, Isadora Cristina, Costa, Dorcas Lamounier, Costa, Carlos Henrique Nery, Andrade, Bruno de Bezerril, Akrami, Kevan, de Oliveira, Camila Indiani, Boaventura, Viviane Sampaio, Barral-Netto, Manoel, Barral, Aldina, Vandamme, Anne-Mieke, Van Weyenbergh, Johan, Khouri, Ricardo“…Visceral leishmaniasis is an opportunistic disease in HIV-1 infected individuals, unrecognized as a determining factor for AIDS diagnosis. …”
Publicado 2023
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4671por Rocha, Rafael, Gonçalves, Luzia, Conceição, Cláudia, Andrade, Patrícia, Cristóvão, José Manuel, Condeço, Jorge, Delgado, Beatriz, Caeiro, Cristina, Kuzmenko, Tetyana, Vasconcelos, Eugénia, Escoval, Maria Antónia, Rey, Carmen, Guz, Madalina, Norte, Cláudia, Aldeia, Carlos, Cruz, Diego, Maia, Carla“…Overall, 72.3% of participants had previously heard of leishmaniasis and, in multivariate analysis, a higher Knowledge score was associated with age 25–40 years, female sex, ownership of dogs, and higher education. …”
Publicado 2023
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4672por Osero, Bernard Ong’ondo, Cele, Zama, Aruleba, Raphael Taiwo, Maine, Rebeng A., Ozturk, Mumin, Lutz, Manfred B., Brombacher, Frank, Hurdayal, Ramona“…IL-4 and IL-13 cytokines have been associated with a non-healing phenotype in murine leishmaniasis in L. mexicana -infected BALB/c mice as demonstrated in IL-4(−/−), IL-13(−/−) and IL-4Rα(-/-) global knockout mouse studies. …”
Publicado 2022
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4673por Heeren, Senne, Maes, Ilse, Sanders, Mandy, Lye, Lon-Fye, Arevalo, Jorge, Llanos-Cuentas, Alejandro, Garcia, Lineth, Lemey, Philippe, Beverley, Stephen M, Cotton, James A, Dujardin, Jean-Claude, den Broeck, Frederik Van“…Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis parasites and their endosymbiotic Leishmania RNA virus. …”
Publicado 2023
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4674por Sadlova, Jovana, Vojtkova, Barbora, Lestinova, Tereza, Becvar, Tomas, Frynta, Daniel, Benallal, Kamal Eddine, Mekarnia, Nalia, Harrat, Zoubir, Volf, Petr“…Leishmaniases are neglected diseases caused by protozoans of the genus Leishmania that threaten millions of people worldwide. Cutaneous leishmaniasis (CL) caused by L. major is a typical zoonosis transmitted by phlebotomine sand flies and maintained in rodent reservoirs. …”
Publicado 2023
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4675por Rosário, Jânia dos Santos, Moreira, Fábio Henrique, Rosa, Lara Hewilin Fernandes, Guerra, Wendell, Silva-Caldeira, Priscila Pereira“…Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. …”
Publicado 2023
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4676por Volpedo, Greta, Pacheco-Fernandez, Thalia, Oljuskin, Timur, Markle, Hannah L., Azodi, Nazli, Hamano, Shinjiro, Matlashewski, Greg, Gannavaram, Sreenivas, Nakhasi, Hira L., Satoskar, Abhay R.“…Leishmaniasis is a tropical disease prevalent in 90 countries. …”
Publicado 2023
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4677“…The requirement of cholesterol for internalization of eukaryotic pathogens like protozoa (Leishmaniasis, Malaria and Toxoplasmosis) and the exchange of cholesterol along with other metabolites during reproduction in Schistosomes (helminths) under variable circumstances are poorly understood. …”
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4678por Joshi, Trupti, Rodriguez, Susana, Perovic, Vladimir, Cockburn, Ian A., Stäger, Simona“…Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are required for the development of protective immunity. …”
Publicado 2009
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4679por Lexchin, Joel“…This conclusion is relevant not just for the most neglected diseases such as leishmaniasis but even for global diseases such as cancer and cardiovascular disease. …”
Publicado 2010
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4680“…In this study, we used the experimental model of visceral leishmaniasis to investigate the role of IRF-5 in the generation of Th1 responses and in the formation of Th1-type liver granulomas in Leishmania donovani infected mice. …”
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