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  1. 4661
    “…There is a need for new, cost-effective drugs to treat leishmaniasis. A strategy based on traditional medicine practiced in Bolivia led to the discovery of the 2-substituted quinoline series as a source of molecules with antileishmanial activity and low toxicity. …”
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    The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates
  2. 4662
    “…Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the genus Leishmania. …”
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    The pathogenicity and virulence of Leishmania - interplay of virulence factors with host defenses
  3. 4663
    “…CASE PRESENTATION: We present four cases of secondary HLH, highlighting the demographic and clinical characteristics of these patients, underlying triggers (including systemic lupus erythematosus, lymphoproliferative disorders, and leishmaniasis), together with challenges associated with the diagnosis and treatment of this rare disorder and a brief review of literature. …”
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    Adult secondary hemophagocytic lymphohistiocytosis
  4. 4664
    “…Filariae-derived immunosuppression can also be exploited to treat other inflammatory diseases and immunopathologic states of parasitic diseases, such as cerebral malaria, and to prevent leishmaniasis. This paper reviews immunomodulatory mechanisms acquired by these filariae for their own survival and their potential application in the development of novel therapeutic approaches against parasitic and inflammatory diseases. …”
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    Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology
  5. 4665
    “…Our study defines the ‘where’ and ‘when’ implement the actions to mitigate leishmaniasis cases.…”
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    Abundance of Lutzomyia longipalpis and Nyssomyia whitmani, the Leishmania spp. vectors in northeastern of Argentina: Are spatial and temporal changing patterns consistence?
  6. 4666
    “…Alcyosterone (5) and several alcyopterosins were similarly potent against the protist Leishmania donovani, the causative agent of leishmaniasis, a disfiguring disease that can be fatal if not treated. …”
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    Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.
  7. 4667
    “…[Image: see text] Miltefosine is a repurposed anticancer drug and currently the only orally administered drug approved to treat the neglected tropical disease leishmaniasis. Miltefosine is hygroscopic and must be stored at subzero temperatures. …”
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    Integral Role of Water in the Solid-State Behavior of the Antileishmanial Drug Miltefosine
  8. 4668
    “…Parasitic diseases, especially those caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, and lymphatic filariasis, are the cause of millions of morbidities and deaths every year, mainly in tropical regions. …”
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    Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review
  9. 4669
    “…BACKGROUND: Leishmaniasis is a zoonotic disease endemic in the Mediterranean region where Leishmania infantum is the causative agent of human and canine infection. …”
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    High-resolution melting (HRM)-based detection of polymorphisms in the malic enzyme and glucose-6-phosphate isomerase genes for Leishmania infantum genotyping
  10. 4670
    “…Visceral leishmaniasis is an opportunistic disease in HIV-1 infected individuals, unrecognized as a determining factor for AIDS diagnosis. …”
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    High seroprevalence of Leishmania infantum is linked to immune activation in people with HIV: a two-stage cross-sectional study in Bahia, Brazil
  11. 4671
    “…Overall, 72.3% of participants had previously heard of leishmaniasis and, in multivariate analysis, a higher Knowledge score was associated with age 25–40 years, female sex, ownership of dogs, and higher education. …”
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    Prevalence of asymptomatic Leishmania infection and knowledge, perceptions, and practices in blood donors in mainland Portugal
  12. 4672
    “…IL-4 and IL-13 cytokines have been associated with a non-healing phenotype in murine leishmaniasis in L. mexicana -infected BALB/c mice as demonstrated in IL-4(−/−), IL-13(−/−) and IL-4Rα(-/-) global knockout mouse studies. …”
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    Interleukin-4 Responsive Dendritic Cells Are Dispensable to Host Resistance Against Leishmania mexicana Infection
  13. 4673
    “…Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis parasites and their endosymbiotic Leishmania RNA virus. …”
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    Parasite hybridization promotes spreading of endosymbiotic viruses
  14. 4674
    “…Leishmaniases are neglected diseases caused by protozoans of the genus Leishmania that threaten millions of people worldwide. Cutaneous leishmaniasis (CL) caused by L. major is a typical zoonosis transmitted by phlebotomine sand flies and maintained in rodent reservoirs. …”
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    Infectiousness of Asymptomatic Meriones shawi, Reservoir Host of Leishmania major
  15. 4675
    “…Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. …”
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    Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome
  16. 4676
    “…Leishmaniasis is a tropical disease prevalent in 90 countries. …”
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    Leishmania mexicana centrin knockout parasites promote M1-polarizing metabolic changes
  17. 4677
    “…The requirement of cholesterol for internalization of eukaryotic pathogens like protozoa (Leishmaniasis, Malaria and Toxoplasmosis) and the exchange of cholesterol along with other metabolites during reproduction in Schistosomes (helminths) under variable circumstances are poorly understood. …”
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    Role of cholesterol in parasitic infections
  18. 4678
    “…Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are required for the development of protective immunity. …”
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    B7-H1 Blockade Increases Survival of Dysfunctional CD8(+) T Cells and Confers Protection against Leishmania donovani Infections
  19. 4679
    por Lexchin, Joel
    Publicado 2010
    “…This conclusion is relevant not just for the most neglected diseases such as leishmaniasis but even for global diseases such as cancer and cardiovascular disease. …”
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    One step forward, one step sideways? Expanding research capacity for neglected diseases
  20. 4680
    “…In this study, we used the experimental model of visceral leishmaniasis to investigate the role of IRF-5 in the generation of Th1 responses and in the formation of Th1-type liver granulomas in Leishmania donovani infected mice. …”
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    Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection
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