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4721por Telleria, Erich Loza, Martins-da-Silva, Andrea, Tempone, Antonio Jorge, Traub-Csekö, Yara Maria“…Phlebotomine sand flies are proven vectors of several aetiological agents including viruses, bacteria and the trypanosomatid Leishmania, which are responsible for diseases such as viral encephalitis, bartonellosis and leishmaniasis, respectively. All metazoans in nature coexist intimately with a community of commensal microorganisms known as microbiota. …”
Publicado 2018
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4722“…Differential diagnosis includes leishmaniasis, pyoderma gangrenosum, eschars and papulonecrotic tuberculides. …”
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4723por Kazemi Oskuee, Reza, Jaafari, Mahmoud Reza, Moghaddasi, Mahdi, Rivandi, Mahdi, Afzaljavan, Fahime, Mohajeri, Mohammad, Ramezani, Mohammad“…OBJECTIVE: The extract of different species of Euphorbia has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the in vitro leishmanicidal effect of Euphorbia petiolata (E. petiolata) extract. …”
Publicado 2018
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4724“…Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. …”
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4725“…Infectious diseases such as trypanosomiasis and leishmaniasis are considered neglected tropical diseases due the lack for many years of research and development into new drug treatments besides the high incidence of mortality and the lack of current safe and effective drug therapies. …”
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4726por Morais, Thiago R., da Costa-Silva, Thais A., Tempone, Andre G., Borborema, Samanta Etel T., Scotti, Marcus T., de Sousa, Raquel Maria F., Araujo, Ana Carolina C., de Oliveira, Alberto, de Morais, Sérgio Antônio L., Sartorelli, Patricia, Lago, João Henrique G.“…Leishmaniasis and Chagas are diseases caused by parasitic protozoans that affect the poorest population in the World, causing a high mortality and morbidity. …”
Publicado 2014
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4727“…Sleeping sickness, Chagas disease, Leishmaniasis, and Malaria are infectious diseases caused by unicellular eukaryotic parasites (“protozoans”). …”
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4728por Moraes, Lienne S., Donza, Marcio R. H., Rodrigues, Ana Paula D., Silva, Bruno J. M., Brasil, Davi S. B., Zoghbi, Maria das Graças B., Andrade, Eloísa H. A., Guilhon, Giselle M. S. P., Silva, Edilene O.“…The low toxicity to macrophages and the effects against promastigotes and amastigotes are suggestive that (+)-phyllanthidine could be a promising antileishmanial agent for treating cutaneous leishmaniasis.…”
Publicado 2015
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4729por Loría-Cervera, Elsy Nalleli, Sosa-Bibiano, Erika Ivett, Van Wynsberghe, Nicole R., Torres-Castro, Jimmy Raymundo, Andrade-Narváez, Fernando José“…Localized cutaneous leishmaniasis (LCL) is endemic in Mexico, mainly in the states of Campeche and Quintana Roo, hyperendemic areas of Leishmania (Leishmania) mexicana transmission. …”
Publicado 2019
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4730por Jha, Ashish, Adhikari, Sudeep, Sigdel, Keshav Raj, Paudyal, Buddhi, Basnyat, Buddha, Kayastha, Gyan, Pradhan, Sumita, Risal, Ujjwol, Poudel, Jiwan“…Liposomal amphotericin B is stocked by the government of Nepal for free supply to patients with visceral leishmaniasis, but the policy does not allow the drug to be dispensed for other infections. …”
Publicado 2019
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4731“…BACKGROUND: The human parasite Leishmania (V.) panamensis is one of the pathogenic species responsible for cutaneous leishmaniasis in Central and South America. Despite its importance in molecular parasitology, its mitochondrial genome, divided into minicircles and maxicircles, haven’t been described so far. …”
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4732por Diouani, Mohamed Fethi, Ouerghi, Oussama, Belgacem, Kamel, Sayhi, Maher, Ionescu, Radu, Laouini, Dhafer“…Sensitive and reliable approaches targeting the detection of Leishmania are critical for effective early diagnosis and treatment of leishmaniasis. In this frame, this paper describes a rapid quantification assay to detect Leishmania parasites based on the combination of the electrocatalytic ability of gold nanoparticles (AuNPs) to act as a catalyst for the hydrogen formation reaction along with the specificity of the interaction between casein and the major surface protease of the Leishmania parasite, GP63. …”
Publicado 2019
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4733por Aguilera, Elena, Perdomo, Cintya, Espindola, Alejandra, Corvo, Ileana, Faral-Tello, Paula, Robello, Carlos, Serna, Elva, Benítez, Fátima, Riveros, Rocío, Torres, Susana, Vera de Bilbao, Ninfa I., Yaluff, Gloria, Alvarez, Guzmán“…Chagas disease and Leishmaniasis are neglected endemic protozoan diseases recognized as public health problems by the World Health Organization. …”
Publicado 2019
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4734por Sloan, Megan A., Brooks, Karen, Otto, Thomas D., Sanders, Mandy J., Cotton, James A., Ligoxygakis, Petros“…Trypanosomatid parasites are causative agents of important human and animal diseases such as sleeping sickness and leishmaniasis. Most trypanosomatids are transmitted to their mammalian hosts by insects, often belonging to Diptera (or true flies). …”
Publicado 2019
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4735“…Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty years, remains the gold standard in the treatment of life-threatening invasive fungal infections and visceral leishmaniasis. Due to its poor water solubility and membrane permeability, AmB is conventionally formulated with deoxycholate as a micellar suspension for intravenous administration, but severe infusion-related side effects and nephrotoxicity hamper its therapeutic potential. …”
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4736por Batista, Fernanda A. H., Ramos, Sérgio L., Tassone, Giusy, Leitão, Andrei, Montanari, Carlos A., Botta, Maurizio, Mori, Mattia, Borges, Júlio C.“…Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. …”
Publicado 2020
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4737Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases“…Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory infection, and leishmaniasis seems beneficial. In contrast, the results for the common cold and malaria are still not conclusive, and zinc was ineffective in most vaccination and rheumatoid arthritis studies. …”
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4738“…Trypanosomatid parasites are causative agents of important human and animal diseases such as sleeping sickness and leishmaniasis. Most trypanosomatids are transmitted to their mammalian hosts by insects, often belonging to Diptera (or true flies). …”
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4739por Calvo, Alba, Moreno, Esther, Larrea, Esther, Sanmartín, Carmen, Irache, Juan Manuel, Espuelas, Socorro“…This work addresses the preparation of BER-loaded liposomes with the aim to prevent its rapid liver metabolism and improve the drug selective delivery to the infected organs in visceral leishmaniasis (VL). BER liposomes (LP-BER) displayed a mean size of 120 nm, negative Z-potential of −38 mV and loaded 6 nmol/μmol lipid. …”
Publicado 2020
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4740“…Leishmaniasis and trypanosomiasis are largely neglected diseases prevailing in tropical and subtropical conditions. …”
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