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4841“…(e.g., L. infantum in southern Europe) affect about 12 million people worldwide and are characterized by a wide spectrum of clinical forms in humans, ranging from cutaneous to fatal visceral leishmaniasis. To establish and maintain the infection, these protozoa are dependent on the secretion of effector molecules into the host for modulating their immune system. …”
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4842por Zulfiqar, Bilal, Jones, Amy J., Sykes, Melissa L., Shelper, Todd B., Davis, Rohan A., Avery, Vicky M.“…Kinetoplastid parasites cause vector-borne parasitic diseases including leishmaniasis, human African trypanosomiasis (HAT) and Chagas disease. …”
Publicado 2017
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4843por Le, Thanh Binh, Beaufay, Claire, Nghiem, Duc Trong, Mingeot-Leclercq, Marie-Paule, Quetin-Leclercq, Joëlle“…Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. …”
Publicado 2017
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4844por Wulsten, Imke F., Costa-Silva, Thais A., Mesquita, Juliana T., Lima, Marta L., Galuppo, Mariana K., Taniwaki, Noemi N., Borborema, Samanta E. T., Da Costa, Fernando B., Schmidt, Thomas J., Tempone, Andre G.“…Depending on the parasite species, different clinical forms are known as cutaneous, muco-cutaneous, and the visceral leishmaniasis (VL). VL is particularly fatal and the therapy presents limitations. …”
Publicado 2017
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4845“…Studies on the distribution of sand flies are important for the control of leishmaniasis in endemic and neighboring areas. In the present study polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) was used to identify the distribution of sand flies in Al-Madinah and Asir Regions of Saudi Arabia using PCR–RFLP of 18S ribosomal RNA gene. …”
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4846por Hotez, Peter J.“…Currently, the only licensed vaccines for NTDs include those for yellow fever, dengue, and rabies, although several other NTD vaccines for hookworm disease, schistosomiasis, leishmaniasis, and Zika and Ebola virus infections are in different stages of clinical development, while others are at the preclinical development stage. …”
Publicado 2018
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4847por do Carmo, Dominique F. Moura, Amaral, Ana Cláudia Fernandes, Machado, Gérzia M. C., Leon, Leonor Laura, Silva, Jefferson Rocha de Andrade“…The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs.…”
Publicado 2012
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4848por de Toledo, Juliano S., Ambrósio, Sergio R., Borges, Carly H. G., Manfrim, Viviane, Cerri, Daniel G., Cruz, Angela K., Da Costa, Fernando B.“…Natural compounds represent a rich and promising source of novel, biologically active chemical entities for treating leishmaniasis. Sesquiterpene lactones are a recognized class of terpenoids with a wide spectrum of biological activities, including activity against Leishmania spp. …”
Publicado 2014
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4849por Barros, Luiz Marivando, Duarte, Antonia Eliene, Morais-Braga, Maria Flaviana Bezerra, Waczuk, Emily Pansera, Vega, Celeste, Leite, Nadghia Figueiredo, Alencar de Menezes, Irwin Rose, Coutinho, Henrique Douglas Melo, Rocha, João Batista Teixeira, Kamdem, Jean Paul“…Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. …”
Publicado 2016
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4850“…We review herein, the recent advances on the role of leptin in malnutrition in pathogenesis of infectious diseases with a particular emphasis on parasitic diseases such as Leishmaniasis, Trypanosomiasis, Amoebiasis, and Malaria.…”
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4851por Turcano, Lorenzo, Torrente, Esther, Missineo, Antonino, Andreini, Matteo, Gramiccia, Marina, Di Muccio, Trentina, Genovese, Ilaria, Fiorillo, Annarita, Harper, Steven, Bresciani, Alberto, Colotti, Gianni, Ilari, Andrea“…Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/tryparedoxin peroxidase system of Leishmania to neutralize hydrogen peroxide produced by host macrophages during infection. …”
Publicado 2018
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4852por Hendrickx, S., Bulté, D., Van den Kerkhof, M., Cos, P., Delputte, P., Maes, L., Caljon, G.“…Although miltefosine (MIL) has only been approved for the treatment of visceral leishmaniasis (VL) in 2002, its application in monotherapy already led to the development of two confirmed MIL-resistant isolates by 2009. …”
Publicado 2018
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4853por Damasceno, Jaqueline Lopes, Arnet, Yadira Fernández, Fortunato, Giovanna Capaldi, Girotto, Luiza, Marena, Gabriel Davi, Rocha, Beatriz Patti, Resende, Flávia Aparecida, Ambrosio, Sergio Ricardo, Veneziani, Rodrigo Cássio Sola, Bastos, Jairo Kenupp, Martins, Carlos Henrique Gomes“…Kaurenoic acid is a naturally occurring diterpene found in Copaifera and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Bearing in mind the fact that the Ames test is an excellent tool to assess the safety of extracts, oils, and phytochemicals isolated from medicinal plants, from it, we evaluate the mutagenic potential of four species, between oleoresins (C. oblongifolia; C. langsdorffii) and leaves extracts (C. lucens; C. multijuga), of the Copaifera genus and also of kaurenoic acid, which is one of its major compounds. …”
Publicado 2019
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4854por Mostafavi, Mahshid, Khazaeli, Payam, Sharifi, Iraj, Farajzadeh, Saeedeh, Sharifi, Hamid, Keyhani, Alireza, Parizi, Maryam Hakimi, Kakooei, Sina“…There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. …”
Publicado 2019
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4855por Prakash, Ohm, Führing, Jana, Post, John, Shepherd, Sharon M., Eadsforth, Thomas C., Gray, David, Fedorov, Roman, Routier, Françoise H.“…Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide. …”
Publicado 2019
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4856por Galkina, Anna, Krause, Nico, Lenz, Mairin, Daniliuc, Constantin G., Kaiser, Marcel, Schmidt, Thomas J.“…Its activity against Trypanosoma brucei rhodesiense (causative agent of East African Human Typanosomiasis, Trypanosoma cruzi (Chagas Disease), Leishmania donovani (Visceral Leishmaniasis) and Plasmodium falciparum (Tropical Malaria) as well as cytotoxicity against rat skeletal myoblasts (L6 cell line) was determined along with those of the hitherto untested 4,15-iso-atriplicolide methacrylate and isobutyrate. …”
Publicado 2019
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4857“…BACKGROUND: Topical treatment of New World cutaneous leishmaniasis can be affected by bacterial coinfection, hyperkeratosis, and transdermal drug delivery. …”
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4858por Akinsolu, Folahanmi T., Nemieboka, Priscilla O., Njuguna, Diana W., Ahadji, Makafui N., Dezso, Dora, Varga, Orsolya“…Results: One of the major findings is that six NTDs have information on drug resistance, namely human African trypanosomiasis, leishmaniasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, and trachoma. …”
Publicado 2019
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4859“…For a long time Leishmaniasis had been considered as a neglected tropical disease. …”
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4860por Zacharova, Marija K., Tulloch, Lindsay B., Gould, Eoin R., Fraser, Andrew L., King, Elizabeth F., Menzies, Stefanie K., Smith, Terry K., Florence, Gordon J.“…The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible for the severely debilitating neglected Tropical diseases of African sleeping sickness, Chagas disease and leishmaniasis, respectively. As part of our ongoing programme exploring the potential of simplified analogues of the acetogenin chamuvarinin we identified the T. brucei FoF1‐ATP synthase as a target of our earlier triazole analogue series. …”
Publicado 2019
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