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4881por Ferreira, Thalita C. S., Sauter, Ismael P., Borda-Samper, Lina, Bentivoglio, Enyd, DaMata, Jarina P., Taniwaki, Noemi N., Orrego, Patrício R., Araya, Jorge E., Lincopan, Nilton, Cortez, Mauro“…Here, we show the antileishmanial activity of DODAB nano-sized cationic bilayer fragments on stationary-phase promastigotes and amastigotes of Leishmania amazonensis, the causative agent of cutaneous leishmaniasis. Upon treatment with DODAB, we analyzed the parasite surface zeta-potential, parasite viability, cellular structural modifications, and intracellular proliferation. …”
Publicado 2020
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4882por Thomas, Michael G., De Rycker, Manu, Wall, Richard J., Spinks, Daniel, Epemolu, Ola, Manthri, Sujatha, Norval, Suzanne, Osuna-Cabello, Maria, Patterson, Stephen, Riley, Jennifer, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Naylor, Claire, Fiandor, Jose M., Wyatt, Paul G., Marco, Maria, Wyllie, Susan, Read, Kevin D., Miles, Timothy J., Gilbert, Ian H.“…[Image: see text] Visceral leishmaniasis (VL) is a parasitic infection that results in approximately 26 000–65 000 deaths annually. …”
Publicado 2020
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4883por Mokdadi, Molka, Abdelkrim, Yosser Zina, Banroques, Josette, Huvelle, Emmeline, Oualha, Rafeh, Yeter-Alat, Hilal, Guizani, Ikram, Barhoumi, Mourad, Tanner, N. Kyle“…In this paper, we identified and aligned the protein sequences of 28 different DEAD-box proteins from the kinetoplast-protozoan parasite Leishmania infantum, which is the cause of the visceral form of leishmaniasis that is often lethal if left untreated, and compared them with the consensus sequence derived from DEAD-box proteins in general, and from the Ded1/DDX3 subfamily in particular, from a wide variety of other organisms. …”
Publicado 2021
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4884por Alcazar, Wilmer, Alakurtti, Sami, Padrón-Nieves, Maritza, Tuononen, Maija Liisa, Rodríguez, Noris, Yli-Kauhaluoma, Jari, Ponte-Sucre, Alicia“…Conclusion: Our results suggest that due to their efficacy and selectivity against intracellular parasites and the potential mechanisms underlying their leishmanicidal effect, the compounds 18 and 22 could be used as tools for designing new chemotherapies against leishmaniasis.…”
Publicado 2021
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4885por Levaique, Hélène, Pamlard, Olivier, Apel, Cécile, Bignon, Jérôme, Arriola, Margaux, Kuhner, Robin, Awang, Khalijah, Loiseau, Philippe M., Litaudon, Marc, Pomel, Sébastien“…Leishmaniasis is a vector-borne disease caused by the protozoan parasite Leishmania found in tropical and sub-tropical areas, affecting 12 million people around the world. …”
Publicado 2021
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4886“…Leishmaniasis are neglected diseases caused by several species of Leishmania that affect humans and many domestic and wild animals with a worldwide distribution. …”
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4887por Solano-Gálvez, Sandra-Georgina, Álvarez-Hernández, Diego-Abelardo, Gutiérrez-Kobeh, Laila, Vázquez-López, Rosalino“…Leishmania is an intracellular protozoan parasite that causes a wide spectrum of diseases known as leishmaniasis. This parasite displays different strategies, including apoptosis inhibition, to down-regulate host cell defense mechanisms in order to perpetuate infection.…”
Publicado 2021
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4888por Telleria, Erich Loza, Tinoco-Nunes, Bruno, Leštinová, Tereza, de Avellar, Lívia Monteiro, Tempone, Antonio Jorge, Pitaluga, André Nóbrega, Volf, Petr, Traub-Csekö, Yara Maria“…We focused on understanding the role of the AMPs attacin (Att), cecropin (Cec), and four defensins (Def1, Def2, Def3, and Def4) in Lutzomyia longipalpis, the main vector of visceral leishmaniasis in the Americas. Larvae and adults were collected under different feeding regimens, in addition to females artificially infected by Leishmania infantum. …”
Publicado 2021
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4889por Van den Kerkhof, Magali, Leprohon, Philippe, Mabille, Dorien, Hendrickx, Sarah, Tulloch, Lindsay B., Wall, Richard J., Wyllie, Susan, Chatelain, Eric, Mowbray, Charles E., Braillard, Stéphanie, Ouellette, Marc, Maes, Louis, Caljon, Guy“…Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. …”
Publicado 2021
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4890“…Sodium antimonials are one of the major and common drugs used against visceral form leishmaniasis (VL). However, the development of drug resistance makes it difficult to manage this disease. …”
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4891por Di Cosola, Michele, Ambrosino, Mariateresa, Limongelli, Luisa, Favia, Gianfranco, Santarelli, Andrea, Cortelazzi, Roberto, Lo Muzio, Lorenzo“…The diagnostic procedures followed in these patients included: detailed medical history, clinical and histological examination, computed tomography and magnetic resonance imaging, laboratory findings (complete blood count, sedimentation rate, antinuclear antibody test, rheumatoid factor, venereal disease research laboratory test, leishmaniasis and fungal serology, antineutrophil cytoplasmic antibodies ANCA test), and chest X-ray. …”
Publicado 2021
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4892por Mubayi, Anuj, Pandey, Abhishek, Brasic, Christine, Mubayi, Anamika, Ghosh, Parijat, Ghosh, Aditi“…We illustrate applicability of our method by applying data on various public health problems, including infectious diseases (Ebola, SARS, and Leishmaniasis) and social issues (obesity and alcohol drinking) to compute transmission rates over time. …”
Publicado 2021
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4893por Hall, Martin J. R., Ghosh, Debashis, Martín-Vega, Daniel, Clark, Brett, Clatworthy, Innes, Cheke, Robert A., Rogers, Matthew E.“…Leishmaniasis is a debilitating disease of the tropics, subtropics and southern Europe caused by Leishmania parasites that are transmitted during blood feeding by phlebotomine sand flies (Diptera: Psychodidae). …”
Publicado 2021
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4894por Martín-Escolano, Rubén, Etxebeste-Mitxeltorena, Mikel, Martín-Escolano, Javier, Plano, Daniel, Rosales, María J., Espuelas, Socorro, Moreno, Esther, Sánchez-Moreno, Manuel, Sanmartín, Carmen, Marín, Clotilde“…Selenium and their derivatives have emerged as an interesting strategy for the treatment of different prozotoan diseases, such as African trypanosomiasis, leishmaniasis, and malaria. In the case of Chagas disease, diverse selenium scaffolds have been reported with antichagasic activity in vitro and in vivo. …”
Publicado 2021
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4895por Clementino, Leandro da Costa, Fernandes, Guilherme Felipe Santos, Prokopczyk, Igor Muccilo, Laurindo, Wilquer Castro, Toyama, Danyelle, Motta, Bruno Pereira, Baviera, Amanda Martins, Henrique-Silva, Flávio, dos Santos, Jean Leandro, Graminha, Marcia A. S.“…Leishmaniasis is a neglected disease that affects 12 million people living mainly in developing countries. …”
Publicado 2021
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4896por Algarabel, Miriam, Fernández-Rubio, Celia, Musilova, Katerina, Peña-Guerrero, José, Vacas, Andrés, Larrea, Esther, Nguewa, Paul A.“…Leishmaniasis is a neglected tropical disease caused by Leishmania spp. …”
Publicado 2021
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4897“…Phlebotomus papatasi is the vector of Leishmania major, causing cutaneous leishmaniasis in the Old World. We investigated whether P. papatasi immunity genes were expressed toward L. major, commensal gut microbes, or a combination of both. …”
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4898por Grace, Cooper Alastair, Forrester, Sarah, Silva, Vladimir Costa, Carvalho, Kátia Silene Sousa, Kilford, Hannah, Chew, Yen Peng, James, Sally, Costa, Dorcas L, Mottram, Jeremy C, Costa, Carlos C H N, Jeffares, Daniel C“…The Leishmania donovani species complex is the causative agent of visceral leishmaniasis, which cause 20–40,000 fatalities a year. …”
Publicado 2021
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4899por Mackay, Alison M.“…Daylight PDT may find broader antimicrobial applications than just Acne and Cutaneous Leishmaniasis, and Ambulatory PDT devices could become popular in regions where resources are limited or daylight exposure is not possible or inappropriate. …”
Publicado 2022
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4900por Ganguly, Satarupa, Ghoshal, Bartika, Banerji, Ishani, Bhattacharjee, Shreya, Chakraborty, Sreemoyee, Goswami, Avijit, Mukherjee, Kamalika, Bhattacharyya, Suvendra N“…Leishmania donovani, the causative agent of visceral leishmaniasis, infects and resides within tissue macrophage cells. …”
Publicado 2022
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