-
4941por Singh, Neeloo, Kaur, Jaspreet, Kumar, Pranav, Gupta, Swati, Singh, Nasib, Ghosal, Angana, Dutta, Avijit, Kumar, Ashutosh, Tripathi, RamaPati, Siddiqi, Mohammad Imran, Mandal, Chitra, Dube, Anuradha“…The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis. The enzyme pteridine reductase 1 (PTR1) of L. donovani acts as a metabolic bypass for drugs targeting dihydrofolate reductase (DHFR); therefore, for successful antifolate chemotherapy to be developed against Leishmania, it must target both enzyme activities. …”
Publicado 2009
Enlace del recurso
Enlace del recurso
Enlace del recurso
Texto -
4942por Ramírez, Laura, Iborra, Salvador, Cortés, Jimena, Bonay, Pedro, Alonso, Carlos, Barral-Netto, Manoel, Soto, Manuel“…Leishmaniasis is an increasing public health problem and effective vaccines are not currently available. …”
Publicado 2010
Enlace del recurso
Enlace del recurso
Enlace del recurso
Texto -
4943“…We conclude that IL-15 is not functioning as a universal NK-cell priming signal and that IL-18 contributes to the NK-cell response in visceral leishmaniasis. The cytokine requirements for NK-cell activation appear to differ contingent upon the infectious pathogen.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Texto -
4944por Kesari, Shreekant, Bhunia, Gouri Sankar, Kumar, Vijay, Jeyaram, Algarswamy, Ranjan, Alok, Das, Pradeep“…BACKGROUND: In visceral leishmaniasis (VL), phlebotomine vectors are the main target to reduce for control measures. …”
Publicado 2010
Enlace del recurso
Enlace del recurso
Enlace del recurso
Texto -
4945por Kautz-Neu, Kordula, Noordegraaf, Madelon, Dinges, Stephanie, Bennett, Clare L., John, Dominik, Clausen, Björn E., von Stebut, Esther“…A better understanding of the various roles of different DC subsets in cutaneous leishmaniasis will improve the development of a potent therapeutic/prophylactic vaccine.…”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Texto -
4946por do Monte-Neto, Rubens L., Coelho, Adriano C., Raymond, Frédéric, Légaré, Danielle, Corbeil, Jacques, Melo, Maria N., Frézard, Frédéric, Ouellette, Marc“…BACKGROUND: Drug resistance is a major problem in leishmaniasis chemotherapy. RNA expression profiling using DNA microarrays is a suitable approach to study simultaneous events leading to a drug-resistance phenotype. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Texto -
4947por De Muylder, Geraldine, Ang, Kenny K. H., Chen, Steven, Arkin, Michelle R., Engel, Juan C., McKerrow, James H.“…Critical to the success of screening strategies is the proper design of the assay, often implying a compromise between ease/speed and a biologically relevant setting. Leishmaniasis is a major neglected disease with limited therapeutic options. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4948por Ben Hadj Ahmed, Sami, Kaabi, Belhassen, Chelbi, Ifhem, Cherni, Saifeddine, Derbali, Mohamed, Laouini, Dhafer, Zhioua, Elyes“…BACKGROUND: Sand fly saliva has been postulated as a potential vaccine or as a vaccine component within multi component vaccine against leishmaniasis. It is important to note that these studies were performed using long-term colonized Phlebotomus papatasi. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4949“…On the basis of the data presented in this work, we propose that long-chain fatty acyl-CoA ligase enzyme serves as an important protein and a potential target candidate for development of selective inhibitors against leishmaniasis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4950por Khan, Md Gulam Musawwir, Alam, Mohammad Shafiul, Bhuiyan, Abu Toha, Jamil, Maleka Arjumand, Saha, Bijoy, Islam, Mazharul, Haque, Rashidul, Hossain, Moazzem, Jamil, Kazi M.“…In Bangladesh, serological tests have been widely used for the primary screening of visceral leishmaniasis (VL). Several serologic tests are available for the diagnosis of VL. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4951por Oliveira, Carolina Ferreira, Manzoni-de-Almeida, Daniel, Mello, Paula Seixas, Natale, Caio Cotta, Santiago, Helton da Costa, Miranda, Luíza da Silva, Ferraz, Fernanda Oliveira, dos Santos, Liliane Martins, Teixeira, Mauro Martins, Arantes, Rosa Maria Esteves, Vieira, Leda Quercia“…We suggest that this model has some striking similarities to the mucocutaneous clinical form of leishmaniasis.…”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4952por Rougeron, Virginie, De Meeûs, Thierry, Hide, Mallorie, Le Falher, Georges, Bucheton, Bruno, Dereure, Jacques, El-Safi, Sayda H., Dessein, Alain, Bañuls, Anne-Laure“…Leishmania species of the subgenus Leishmania and especially L. donovani are responsible for a large proportion of visceral leishmaniasis cases. The debate on the mode of reproduction and population structure of Leishmania parasites remains opened. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4953por Coelho, Vinicio T. S., Oliveira, Jamil S., Valadares, Diogo G., Chávez-Fumagalli, Miguel A., Duarte, Mariana C., Lage, Paula S., Soto, Manuel, Santoro, Marcelo M., Tavares, Carlos A. P., Fernandes, Ana Paula, Coelho, Eduardo A. F.“…(L.) infantum recognized by antibodies present in the sera of dogs with asymptomatic and symptomatic visceral leishmaniasis (VL). METHODOLOGY/PRINCIPAL FINDINGS: Proteins recognized by sera samples were separated by two-dimensional electrophoresis (2DE) and identified by mass spectrometry. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4954por Rahimi-Moghaddam, Parvaneh, Ebrahimi, Soltan Ahmed, Ourmazdi, Hourmazd, Selseleh, Monawar, Karjalian, Maryam, Haj-Hassani, Giti, Alimohammadian, Mohammad Hossein, Mahmoudian, Massoud, Shafiei, Massoumeh“…The in vivo studies were carried out on cutaneous leishmaniasis in outbred mice to evaluate the effects of topical application of the ointment-based extract. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4955por Ilari, Andrea, Baiocco, Paola, Messori, Luigi, Fiorillo, Annarita, Boffi, Alberto, Gramiccia, Marina, Di Muccio, Trentina, Colotti, Gianni“…Auranofin kills the promastigote stage of L. infantum at micromolar concentration; these findings will contribute to the design of new drugs against leishmaniasis.…”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4956por Bern, Caryn, Hightower, Allen W., Chowdhury, Rajib, Ali, Mustakim, Amann, Josef, Wagatsuma, Yukiko, Haque, Rashidul, Kurkjian, Katie, Vaz, Louise E., Begum, Moarrita, Akter, Tangin, Cetre-Sossah, Catherine B., Ahluwalia, Indu B., Dotson, Ellen, Secor, W. Evan, Breiman, Robert F., Maguire, James H.“…Since 1990, South Asia has experienced a resurgence of kala-azar (visceral leishmaniasis). To determine risk factors for kala-azar, we performed cross-sectional surveys over a 3-year period in a Bangladeshi community. …”
Publicado 2005
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4957por Siqueira-Neto, Jair L., Moon, Seunghyun, Jang, Jiyeon, Yang, Gyongseon, Lee, Changbok, Moon, Hong Kee, Chatelain, Eric, Genovesio, Auguste, Cechetto, Jonathan, Freitas-Junior, Lucio H.“…Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4958por Selseleh, Mina, Keshavarz, Hossein, Mohebali, Mehdi, Shojaee, Saeedeh, Selseleh, Monavar, Eshragian, Mohammad Reza, Mansouri, Fatemeh, Modarressi, Mohammad Hossein“…To control the specificity of the rGRA7 other parasitic diseases, for example, echinococcosis, malaria, leishmaniasis, fascioliasis, and strongyloidiasis were tested of which none showed positive results. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4959por da Silva, Eliete Cavalcanti, Dias Rayol, Cynthia, Lys Medeiros, Paloma, Figueiredo, Regina Célia Bressan Queiroz, Piuvezan, Márcia Regina, Brabosa-Filho, José Maria, Fernandes Marinho, Alexsandro, Silva, Teresinha Gonçalves, Militão, Gardenia Carmen Gadelha, Pimentel Cassilhas, Ana Paula, Paes de Andrade, Paulo“…Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoonosis in the American continent, as well as in many other countries in Asia, Africa, and Mediterranean Europe. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4960por Rocha, Marcele Neves, Nogueira, Paula Monalisa, Demicheli, Cynthia, de Oliveira, Ludmila Gonçalvez, da Silva, Meiriane Mariano, Frézard, Frédéric, Melo, Maria Norma, Soares, Rodrigo Pedro“…Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto