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5081por Ferraz, Ricardo, Santarém, Nuno, Santos, Andreia F. M., Jacinto, Manuel L., Cordeiro-da-Silva, Anabela, Prudêncio, Cristina, Noronha, João Paulo, Branco, Luis C., Petrovski, Željko“…This work reported a simple synthetic method, which can be applied to prepare other organic salts based on molecules containing fragile chemical groups, demonstrating the potential of these OSILs-AmB as possible agents against leishmaniasis.…”
Publicado 2022
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5082por Campanholi, Katieli da Silva Souza, Junior, Ranulfo Combuca da Silva, Jaski, Jonas Marcelo, da Silva, Jéssica Bassi, de Oliveira, Mariana Carla, dos Santos, Rafaela Said, Pozza, Magali Soares dos Santos, de Castro-Hoshino, Lidiane Vizioli, Baesso, Mauro Luciano, Cardozo-Filho, Lucio, Bruschi, Marcos Luciano, Caetano, Wilker“…Recently, the number of new cases of cutaneous leishmaniasis has been of concern among health agencies. …”
Publicado 2022
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5083por Lima, Clara M., Santarém, Nuno, Neves, Nuno Costa, Sarmento, Pedro, Carrapato, Carlos, de Sousa, Rita, Cardoso, Luís, Cordeiro-da-Silva, Anabela“…Leishmania infantum, the sand fly-transmitted protozoan parasite responsible for leishmaniasis in humans, dogs, and cats, is endemic in the Iberian Peninsula. …”
Publicado 2022
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5084por Madia, Valentina Noemi, Ialongo, Davide, Patacchini, Elisa, Exertier, Cécile, Antonelli, Lorenzo, Colotti, Gianni, Messore, Antonella, Tudino, Valeria, Saccoliti, Francesco, Scipione, Luigi, Ilari, Andrea, Costi, Roberta, Di Santo, Roberto“…Background: As a result of the paucity of treatment, Leishmaniasis continues to provoke about 60,000 deaths every year worldwide. …”
Publicado 2023
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5085por Andrade, Yasmin Monara Ferreira de Sousa, de Castro, Monara Viera, Tavares, Victor de Souza, Souza, Rayane da Silva Oliveira, Faccioli, Lúcia Helena, Lima, Jonilson Berlink, Sorgi, Carlos Arterio, Borges, Valéria M, Araújo-Santos, Théo“…OBJECTIVES: Herein, we compared LDs and eicosanoids biogenesis in distinct Leishmania species which are etiologic agents of different clinical forms of leishmaniasis. METHODS: For this, promastigotes of Leishmania amazonensis, L. braziliensis and L. infantum were stimulated with polyunsaturated fatty acids (PUFA) and LD and eicosanoid production was evaluated. …”
Publicado 2023
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5086por de Morais, Mayara Castro, Medeiros, Gisele Alves, Almeida, Fernanda Silva, Rocha, Juliana da Câmara, Perez-Castillo, Yunierkis, Keesen, Tatjana de Souza Lima, de Sousa, Damião Pergentino“…Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in South America, the Mediterranean basin, and West and Central Asia. …”
Publicado 2023
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5087por Nicolás-Hernández, Desirée San, Rodríguez-Expósito, Rubén L., López-Arencibia, Atteneri, Bethencourt-Estrella, Carlos J., Sifaoui, Ines, Salazar-Villatoro, Lizbeth, Omaña-Molina, Maritza, Fernández, José J., Díaz-Marrero, Ana R., Piñero, José E., Lorenzo-Morales, Jacob“…Leishmaniasis and Chagas disease affect millions of people worldwide. …”
Publicado 2023
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5088“…CRISPR/Cas9 gene editing has revolutionised loss-of-function experiments in Leishmania, the causative agent of leishmaniasis. As Leishmania lack a functional non-homologous DNA end joining pathway however, obtaining null mutants typically requires additional donor DNA, selection of drug resistance-associated edits or time-consuming isolation of clones. …”
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5089por Cavallieri, Ana Carolina, Katto, Débora Sayuri, Holsback, Luciane, Caldart, Eloiza Teles, Pena, Luana Zaboski, Castilho, Pablo Menegon, Filgueiras, Fernanda Pinheiro, de Souza Marquez, Ellen, Cruz, Mariza Fordellone Rosa, Médici, Kerlei Cristina, Mitsuka-Breganó, Regina, Navarro, Italmar Teodorico“…Leishmaniasis is an anthropozoonosis with vector transmission, and knowledge regarding the occurrence of this parasitosis in sentinels can contribute to infection and disease control measures in humans. …”
Publicado 2023
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5090por Garcia, Andreza R., Amorim, Mariana M. B., Amaral, Ana Claudia F., da Cruz, Jefferson D., Vermelho, Alane B., Nico, Dirlei, Rodrigues, Igor A.“…Human tegumentary leishmaniasis (HTL) is a serious tropical disease caused by Leishmania amazonensis. …”
Publicado 2023
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5091por Abou-Elaaz, Fatima-Zahra, Sereno, Denis, Himmi, Oumnia, Ghamizi, Mohamed, Guernaoui, Souad“…BACKGROUND: Phlebotomus sergenti, the proven vector of Leishmania tropica, the causative agent of anthroponotic cutaneous leishmaniasis, is widely distributed in Morocco. Previous works using molecular markers (Internal Transcribed Spacer 2 rDNA and Cytochrome B mtDNA) hypothesized the existence of multiple closely related populations of sand fly species (cryptic species) that would exhibit distinct vectorial capacities. …”
Publicado 2023
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5092“…Results: The study included 55 cases, on analysis of which the maximum number of infections were those of leishmaniasis accounting for 35%, followed by HIV (29%) and tuberculosis (15%). …”
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5093“…The parasites Trypanosoma brucei (Tb) and Leishmania major (Lm) cause the tropical diseases sleeping sickness, nagana, and cutaneous leishmaniasis. Every year, millions of humans, as well as animals, living in tropical to subtropical climates fall victim to these illnesses’ health threats. …”
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5094por Miles, Suzanne A., Conrad, Sean M., Alves, Renata G., Jeronimo, Selma M.B., Mosser, David M.“…In human patients with active visceral leishmaniasis, high IgG levels are predictive of disease. …”
Publicado 2005
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5095por Meireles-Filho, Antonio CA, Amoretty, Paulo R, Souza, Nataly A, Kyriacou, Charalambos P, Peixoto, Alexandre A“…RESULTS: Here we describe the sequence, genomic organization and circadian expression of cycle in the crepuscular/nocturnal hematophagous sandfly Lutzomyia longipalpis, the main vector of visceral leishmaniasis in the Americas. Deduced amino acid sequence revealed that sandfly cycle has a C-terminal transactivation domain highly conserved among eukaryotes but absent in D. melanogaster. …”
Publicado 2006
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5096Publicado 1990“…Leishmaniasis provides a biologically relevant model to analyze the heterogeneity of CD4+ T cells and may lead to answering the major question of the mechanism for the preferential induction of T helper type 1 (Th1) and Th2 cells. …”
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5097Publicado 1993“…Together, these data indicate that the stimulation of NK cells, through the production of IFN-gamma, plays an important role in initiating Th1 cell differentiation in leishmaniasis and in controlling early resistance to L. major.…”
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5098por Valenzuela, Jesus G., Belkaid, Yasmine, Garfield, Mark K., Mendez, Susana, Kamhawi, Shaden, Rowton, Edgar D., Sacks, David L., Ribeiro, José M.C.“…These results indicate that DTH response against saliva provides most or all of the protective effects of this vaccine and that salivary gland proteins or their cDNAs are viable vaccine targets against leishmaniasis.…”
Publicado 2001
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5099por Bringaud, Frédéric, Müller, Michaela, Cerqueira, Gustavo Coutinho, Smith, Martin, Rochette, Annie, El-Sayed, Najib M. A, Papadopoulou, Barbara, Ghedin, Elodie“…Trypanosomatids are unicellular protists that include the human pathogens Leishmania spp. (leishmaniasis), Trypanosoma brucei (sleeping sickness), and Trypanosoma cruzi (Chagas disease). …”
Publicado 2007
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5100“…BACKGROUND: Infection with Leishmania results in a broad spectrum of pathologies where L. infantum and L. donovani cause fatal visceral leishmaniasis and L. major causes destructive cutaneous lesions. …”
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