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5181por Galuppo, Mariana K., de Rezende, Eloiza, Forti, Fabio L., Cortez, Mauro, Cruz, Mario C., Teixeira, Andre A., Giordano, Ricardo J., Stolf, Beatriz S.“…Leishmaniasis is caused by trypanosomatid protozoa of the genus Leishmania, which infect preferentially macrophages. …”
Publicado 2018
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5182por Van den Kerkhof, M., Mabille, D., Chatelain, E., Mowbray, C.E., Braillard, S., Hendrickx, S., Maes, L., Caljon, G.“…OBJECTIVES: Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. Pharmacodynamics studies included both in vitro and in vivo efficacy, cross-resistance profiling against the current antileishmanial reference drugs and evaluation of their cidal activity potential. …”
Publicado 2018
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5183por Roberts, Adam J., Dunne, Joanne, Scullion, Paul, Norval, Suzanne, Fairlamb, Alan H.“…Trypanosomatid parasites are the infectious agents causing Chagas disease, visceral and cutaneous leishmaniasis and human African trypanosomiasis. Recent work of others has implicated an aldo-keto reductase (AKR) in the susceptibility and resistance of Trypanosoma cruzi to benznidazole, a drug used to treat Chagas disease. …”
Publicado 2018
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5184por Trinconi, Cristiana T., Miguel, Danilo C., Silber, Ariel M., Brown, Christopher, Mina, John G.M., Denny, Paul W., Heise, Norton, Uliana, Silvia R.B.“…Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in vitro and in vivo against several species of Leishmania, the etiological agent of leishmaniasis. Using a combination of metabolic labeling with [(3)H]-sphingosine and myo-[(3)H]-inositol, alkaline hydrolysis, HPTLC fractionations and mass spectrometry analyses, we observed a perturbation in the metabolism of inositolphosphorylceramides (IPCs) and phosphatidylinositols (PIs) after treatment of L. amazonensis promastigotes with tamoxifen, with a significant reduction in the biosynthesis of the major IPCs (composed of d16:1/18:0-IPC, t16:0/C18:0-IPC, d18:1/18:0-IPC and t16:0/20:0-IPC) and PIs (sn-1-O-(C(18:0))alkyl -2-O-(C(18:1))acylglycerol-3-HPO(4)-inositol and sn-1-O-(C(18:0))acyl-2-O-(C(18:1))acylglycerol-3-HPO(4)-inositol) species. …”
Publicado 2018
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5185por Aliança, Amanda Silva dos Santos, dos Anjos, Keicyanne Fernanda Lessa, Reis, Thiago Nogueira de Vasconcelos, Higino, Taciana Mirely Maciel, Brelaz-de-Castro, Maria Carolina Accioly, Bianco, Éverson Miguel, de Figueiredo, Regina Celia Bressan Queiroz“…The low toxicity to mammalian cells and the effective activity against promastigotes and amastigotes, point to the use of DME as a promising agent for the treatment of cutaneous leishmaniasis.…”
Publicado 2014
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5186por Damasceno, Jeziel D, Obonaga, Ricardo, Silva, Gabriel L A, Reis-Cunha, João L, Duncan, Samuel M, Bartholomeu, Daniella C, Mottram, Jeremy C, McCulloch, Richard, Tosi, Luiz R O“…Leishmania species are protozoan parasites whose remarkably plastic genome limits the establishment of effective genetic manipulation and leishmaniasis treatment. The strategies used by Leishmania to maintain its genome while allowing variability are not fully understood. …”
Publicado 2018
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5187por Mousavi, Tahereh, Shokohi, Sahar, Abdi, Jahangir, Naserifar, Razi, Ahmadi, Mahmoud, Mirzaei, Asad“…BACKGROUND AND OBJECTIVE: Cutaneous leishmaniasis (CL) is one of the most important diseases worldwide, with a different range of prevalence in endemic areas. …”
Publicado 2018
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5188por Koirala, Kanika Deshpande, Chappuis, François, Verdonck, Kristien, Rijal, Suman, Boelaert, Marleen“…The incidence of malaria and visceral leishmaniasis (VL) was found to be decreasing in Nepal, with some changes of the geographical areas at risk. …”
Publicado 2018
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5189por Zahedifard, Farnaz, Lee, Hyeryon, No, Joo Hwan, Salimi, Mona, Seyed, Negar, Asoodeh, Ahmad, Rafati, Sima“…Leishmaniasis, as a major health problem in tropical and sub-tropical areas in the world, needs novel, safe, nontoxic and plausible therapeutic solutions for its control. …”
Publicado 2019
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5190por da Silva e Silva, João Victor, Cordovil Brigido, Helliton Patrick, Oliveira de Albuquerque, Kelly Cristina, Miranda Carvalho, Josiwander, Ferreira Reis, Jordano, Vinhal Faria, Lara, Coelho-Ferreira, Márlia Regina, Silveira, Fernando Tobias, da Silva Carneiro, Agnaldo, Percário, Sandro, do Rosário Marinho, Andrey Moacir, Dolabela, Maria Fâni“…Chemotherapy is limited in the treatment of leishmaniasis due to the toxic effects of drugs, low efficacy of alternative treatments, and resistance of the parasite. …”
Publicado 2019
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5191por Zhang, Ning, Gao, Peng, Yin, Bao, Li, Jiahe, Wu, Tong, Kuang, Yu, Wu, Wenxue, Li, Jinxiang“…Cathepsin L (CTSL) has been proved to help contain leishmaniasis and mycoplasma infection in mice by supporting cellular immune responses, but the regulatory functions of CTSL on mucosal immune responses haven’t been tested and remain undefined. …”
Publicado 2019
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5192por Ebrahimisadr, Parisa, Ghaffarifar, Fatemeh, Horton, John, Dalimi, Abdolhossein, Sharifi, Zohreh“…Therefore, morphine may have a different function mechanism in treatment of the Leishmaniasis with the L. major.…”
Publicado 2019
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5193por Nacher, Mathieu, Leitao, Terezinha Silva, Gómez, Beatriz L., Couppié, Pierre, Adenis, Antoine, Damasceno, Lisandra, Demar, Magalie, Samayoa, Blanca, Cáceres, Diego H., Pradinaud, Roger, Sousa, Anastacio de Queiroz, Arathoon, Eduardo, Restrepo, Angela“…In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. …”
Publicado 2019
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5194por Yorek, Matthew S., Poudel, Barun, Mazgaeen, Lalita, Pope, R. Marshall, Wilson, Mary E., Gurung, Prajwal“…Leishmaniasis is a global health problem with an estimated report of 2 million new cases every year and more than 1 billion people at risk of contracting this disease in endemic areas. …”
Publicado 2019
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5195por Teixeira, Bárbara Velame Ferreira, Teles, André Lacerda Braga, da Silva, Suellen Gonçalves, Brito, Camila Carane Bitencourt, de Freitas, Humberto Fonseca, Pires, Acássia Benjamim Leal, Froes, Thamires Quadros, Castilho, Marcelo Santos“…Leishmaniasis is a tropical disease found in more than 90 countries. …”
Publicado 2019
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5196por Pasquali, Aline Kuhn Sbruzzi, Baggio, Rafael Antunes, Boeger, Walter Antonio, González-Britez, Nilsa, Guedes, Deborah Carbonera, Chaves, Enmanuel Céspedes, Thomaz-Soccol, Vanete“…Leishmania (Leishmania) infantum is the zoonotic agent of visceral leishmaniasis (VL), a disease with a global distribution. …”
Publicado 2019
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5197por Ennes-Vidal, Vítor, Vitório, Bianca da Silva, Menna-Barreto, Rubem Figueiredo Sadok, Pitaluga, André Nóbrega, Gonçalves-da-Silva, Silvia Amaral, Branquinha, Marta Helena, Santos, André Luis Souza, d’Avila-Levy, Claudia Masini“…OBJECTIVES: Here, we characterised calpains in Leishmania braziliensis, the main causative agent of cutaneous leishmaniasis in Brazil. METHODS/FINDINGS: In total, 34 predicted calpain-like genes were identified. …”
Publicado 2019
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5198por Qian, Men-Bao, Chen, Jin, Bergquist, Robert, Li, Zhong-Jie, Li, Shi-Zhu, Xiao, Ning, Utzinger, Jürg, Zhou, Xiao-Nong“…Meanwhile, about 6000 dengue cases are reported, while the incidence of leishmaniasis, leprosy, and rabies are down at 600 or fewer per year. …”
Publicado 2019
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5199por Casaril, Aline Etelvina, Alonso, Diego Peres, Franco, Karina Garcia, Alvarez, Marcus Vinicius Niz, Barrios, Suellem Petilim Gomes, Fernandes, Wagner de Souza, Infran, Jucelei de Oliveira Moura, Rodrigues, Ana Caroline Moura, Ribolla, Paulo Eduardo Martins, de Oliveira, Alessandra Gutierrez“…Lutzomyia longipalpis is the main vector of Leishmania infantum, the causative agent of visceral leishmaniasis in the Neotropical realm. Its taxonomic status has been widely discussed once it encompasses a complex of species. …”
Publicado 2019
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5200“…BACKGROUND: The first line treatment for cutaneous leishmaniasis is pentavalent antimony such as sodium stibogluconate (pentostam) and meglumine antimonite (glucantime). …”
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