-
5261por Pilling, Olivia A., Reis-Cunha, João L., Grace, Cooper A., Berry, Alexander S. F., Mitchell, Matthew W., Yu, Jane A., Malekshahi, Clara R., Krespan, Elise, Go, Christina K., Lombana, Cláudia, Song, Yun S., Amorim, Camila F., Lago, Alexsandro S., Carvalho, Lucas P., Carvalho, Edgar M., Brisson, Dustin, Scott, Phillip, Jeffares, Daniel C., Beiting, Daniel P.“…In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with a high rate of treatment failure. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5262“…In this study, we use three publicly available, high-throughput screening datasets to train machine learning models to predict biological activities related to inhibition of species that cause leishmaniasis, American trypanosomiasis (Chagas disease), and African trypanosomiasis (sleeping sickness). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5263por Herrera-Acevedo, Chonny, de Menezes, Renata Priscila Barros, de Sousa, Natália Ferreira, Scotti, Luciana, Scotti, Marcus Tullius, Coy-Barrera, Ericsson“…Finally, additional computational studies were performed on DHFR-TS structures from Leishmania species that cause cutaneous and mucocutaneous leishmaniasis in the New World (L. braziliensis, L. panamensis, and L. amazonensis) to explore the targeting potential of these kauranes in these species. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5264por Camacho, Esther, González-de la Fuente, Sandra, Solana, Jose Carlos, Tabera, Laura, Carrasco-Ramiro, Fernando, Aguado, Begoña, Requena, Jose M.“…Leishmania infantum is one of the causative agents of visceral leishmaniases, the most severe form of leishmaniasis. An improved assembly for the L. infantum genome was published five years ago, yet delineation of its transcriptome remained to be accomplished. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5265por Haghani, Iman, Akhtari, Javad, Yahyazadeh, Zahra, Espahbodi, Amirreza, Kermani, Firoozeh, Javidnia, Javad, Hedayati, Mohammad Taghi, Shokohi, Tahereh, Badali, Hamid, Rezaei-Matehkolaei, Ali, Aghili, Seyed Reza, Al-Rawahi, Ahmed, Al-Harrasi, Ahmed, Abastabar, Mahdi, Al-Hatmi, Abdullah M. S.“…Miltefosine, an alkylphosphocholine, is the most recently approved drug for the treatment of both visceral and cutaneous leishmaniasis. Miltefosine in vitro activity against terbinafine-resistant and susceptible T. mentagrophytes/T. interdigitale species complex, including T. indotineae, is limited. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5266“…We previously reported that mice with experimental visceral leishmaniasis (VL) manifest anemia and enhanced hemophagocytosis in the spleen accompanied with decreased SIRPα expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5267por Hadermann, Amber, Heeren, Senne, Maes, Ilse, Dujardin, Jean-Claude, Domagalska, Malgorzata Anna, Van den Broeck, Frederik“…Leishmania aethiopica is a zoonotic Old World parasite transmitted by Phlebotomine sand flies and causing cutaneous leishmaniasis in Ethiopia and Kenya. Despite a range of clinical manifestations and a high prevalence of treatment failure, L. aethiopica is one of the most neglected species of the Leishmania genus in terms of scientific attention. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5268por Gutierrez Guarnizo, Sneider Alexander, Tikhonova, Elena B., Karamyshev, Andrey L., Muskus, Carlos E., Karamysheva, Zemfira N.“…Leishmania is a unicellular protozoan that has a limited transcriptional control and mostly uses post-transcriptional regulation of gene expression, although the molecular mechanisms of the process are still poorly understood. Treatments of leishmaniasis, pathologies associated with Leishmania infections, are limited due to drug resistance. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5269“…It is important to discover accurate diagnostic procedures for leishmaniasis control.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5270por Hughes, Kristelle, Le, Thanh Binh, Van Der Smissen, Patrick, Tyteca, Donatienne, Mingeot-Leclercq, Marie-Paule, Quetin-Leclercq, Joëlle“…Leishmaniasis is a neglected tropical disease that still infects thousands of people per year throughout the world. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5271por Alves, Alex Barbosa, da Silva Bortoleti, Bruna Taciane, Tomiotto-Pellissier, Fernanda, Ganaza, Ana Flávia Marques, Gonçalves, Manoela Daiele, Carloto, Amanda Cristina Machado, Rodrigues, Ana Carolina Jacob, Silva, Taylon Felipe, Nakazato, Gerson, Kobayashi, Renata Katsuko Takayama, Lazarin-Bidóia, Danielle, Miranda-Sapla, Milena Menegazzo, Costa, Idessania Nazareth, Pavanelli, Wander Rogério, Conchon-Costa, Ivete“…American tegumentary leishmaniasis, a zoonotic disease caused by the Leishmania genus, poses significant challenges in treatment, including administration difficulty, low efficacy, and parasite resistance. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5272“…These parasites are the etiological agents of Chagas disease, African trypanosomiasis (sleeping sickness), and leishmaniasis, respectively. Currently, licenced medications for these infections are outdated and often result in harmful side effects, and can be inaccessible to those carrying infections, due to them being classified as neglected tropical diseases (NTDs), meaning that many infected individuals will belong to already marginalised communities in countries already facing socioeconomic challenges. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5273por Ramos-Milaré, Á.C.F.H., Sydor, B.G., Brustolin, A.Á., Lera-Nonose, D.S.S.L., Oyama, J., Silva, E.L., Caetano, W., Campanholi, K.S.S., Demarchi, I.G., Silveira, T.G.V., Lonardoni, M.V.C.“…Leishmaniasis is a neglected disease that affects millions of people worldwide, and special attention should be given to treatment because the available drugs have limitations, which can lead to low therapeutic adherence and parasitic resistance. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5274por Al Rashed, Abdullatif, Al Jindan, Reem, Al Jaroodi, Salma, Al Mohanna, Ahmed, El-Badry, Ayman A.“…OBJECTIVES: Cutaneous leishmaniasis (CL) is considered an overlooked public health threat in KSA. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5275por Retamiro, Karina Miyuki, Nunes, Karine Campos, Zani, Aline Pinto, Zani, Caroline Pinto, Beltran, Laiza Bergamasco, Silva, Sueli de Oliveira, Garcia, Francielle Pelegrin, Ueda-Nakamura, Tânia, Bergamasco, Rosangela, Nakamura, Celso Vataru“…The resulting water is thus more alkaline, which has been shown to be non-toxic to mice and can actually prolong survival. Cutaneous leishmaniasis is a neglected tropical disease, caused by obligate uni- and intracellular protozoa belonging to the genus Leishmania, that can manifest in the form of skin lesions. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5276por Danthanarayana, Adheesha N., Nandy, Suman, Kourentzi, Katerina, Vu, Binh, Shelite, Thomas R., Travi, Bruno L., Brgoch, Jakoah, Willson, Richard C.“…We demonstrated a proof-of-concept assay combining isothermal amplification and lateral flow assay (LFA) for early diagnosis of cutaneous leishmaniasis, a vector-borne infectious disease that affects ca. 700,000 to 1.2 million people annually. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5277por Cowen, Todd, Walmsley, Simon, Karim, Kal, Haser, Resul, Caffrey, Patrick, Piletska, Elena, Rawlings, Bernard, Piletsky, Sergey A.“…Amphotericin B has been an essential drug in the fight against leishmaniasis and fungal pathogens for decades, and has more recently gained attention for the very limited microbial resistance displayed against it. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5278por Silva, Kletey M., Freitas, Dhayn C. A., Medeiros, Sabrina S., Miranda, Laís V. A., Carmo, Jessica B. M., Silva, Roberta G., Becker, Luana L., Abreu, Emanuel S., Buranello, Leonardo, Souza, Maria S. M., Nadruz, Wilson, Fernandes-Silva, Miguel M., Maguire, James H., Toledo-Cornell, Cristina, Silvestre, Odilson M.“…Reinfection was found in 32 (2.3%) participants, and 806 (58.8%) individuals reported a previous history of dengue, malaria, Zika, chikungunya, leprosy, and visceral leishmaniasis. Eight hundred seventy-seven (63.9%) participants reported late symptoms related to COVID-19. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5279por Thomas, Michael G., McGonagle, Kate, Rowland, Paul, Robinson, David A., Dodd, Peter G., Camino-Díaz, Isabel, Campbell, Lorna, Cantizani, Juan, Castañeda, Pablo, Conn, Daniel, Craggs, Peter D., Edwards, Darren, Ferguson, Liam, Fosberry, Andrew, Frame, Laura, Goswami, Panchali, Hu, Xiao, Korczynska, Justyna, MacLean, Lorna, Martin, Julio, Mutter, Nicole, Osuna-Cabello, Maria, Paterson, Christy, Peña, Imanol, Pinto, Erika G., Pont, Caterina, Riley, Jennifer, Shishikura, Yoko, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Wrobel, Karolina, Young, Robert J., Zmuda, Filip, Zuccotto, Fabio, Read, Kevin D., Gilbert, Ian H., Marco, Maria, Miles, Timothy J., Manzano, Pilar, De Rycker, Manu“…We previously reported on the discovery of GSK3494245/DDD01305143, a preclinical candidate for visceral leishmaniasis which acted through inhibition of the Leishmania proteasome. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5280por Salarkia, Ehsan, Sharifi, Iraj, Keyhani, Alireza, Tavakoli Oliaee, Razieh, Khosravi, Ahmad, Sharifi, Fatemeh, Bamorovat, Mehdi, Babaei, Zahra“…The main action of crocin and AmpB involved wide-ranging mechanistic insights for conducting other clinical settings as promising drug candidates for cutaneous leishmaniasis. Therefore, this combination could be esteemed as a basis for a potential bioactive component and a logical source for leishmanicidal drug development against CL in future advanced clinical settings.…”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto