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5281por Cabral, Fernanda V., Cerone, Michela, Persheyev, Saydulla, Lian, Cheng, Samuel, Ifor D. W., Ribeiro, Martha S., Smith, Terry K.“…The emergence of drug resistance in cutaneous leishmaniasis (CL) has become a major problem over the past decades. …”
Publicado 2023
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5282por Pabon-Rodriguez, Felix M., Brown, Grant D., Scorza, Breanna M., Petersen, Christine A.“…The within-host model structure we present here provides a way forward to address vital research questions regarding the understanding progression of complex chronic diseases such as Visceral Leishmaniasis, a parasitic disease causing significant morbidity worldwide.…”
Publicado 2023
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5283por Silva de Jesus Passaes, Anna Carolina, Arantes Dantas, Juliana, Landim Lopes, Fernanda, Pereira Sangi, Diego, Girão Albuquerque, Magaly, Vataru Nakamura, Celso, Yoneda, Julliane“…Neglected tropical diseases, such as leishmaniasis, lead to serious limitations to the affected societies. …”
Publicado 2023
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5284por Kumar, Ravinder, Singh, Rahul, das Chagas Almeida, Ayla, da Trindade Granato, Juliana, de Oliveira Lemos, Ari Sérgio, Kumar, Kushvinder, Patil, Madhuri T., da Silva, Adilson D., Rode, Ambadas B., Coimbra, Elaine S., Salunke, Deepak B.“…The observed in vitro antileishmanial activity along with suitable in silico physicochemical and absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of compound 24 reinforce the imidazo-pyrimidine scaffold as a new antileishmanial pharmacophore and encourage further murine experimental leishmaniasis studies.…”
Publicado 2023
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5285por Sombra Santos, Aline, de Castro Rodrigues, Naya Lúcia, Marciano Fonseca, Francisco Rafael, Braga Fayão Oliveira, Nathalia, Oliveira Loucard, Bianca, Fernandes Heredia, Fabíola, Albuquerque Gomes Nogueira, Teresa Neuma, Monteiro Abreu, Ticiana, Silva dos Santos, Hélcio, Holanda Teixeira, Edson, Almeida Moreira Leal, Luzia Kalyne, Brandim Gomes, Regis Bernardo, Romero Teixeira, Clarissa, Teixeira, Maria Jania“…Treatment of cutaneous leishmaniasis depends on drugs that potentially cause serious side effects and resistance. …”
Publicado 2023
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5286“…Leishmaniasis is a neglected tropical disease, and its severity necessitates the development of a potent and efficient vaccine for the disease; however, no human vaccine has yet been approved for clinical use. …”
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5287“…Also, a general methodology to compare and evaluate models for prediction is presented and illustrated using American cutaneous leishmaniasis, a neglected tropical disease, as an example. …”
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5288por Díaz González, Rosario, Pérez Pertejo, Yolanda, Ordóñez, David, Balaña-Fouce, Rafael, Reguera, Rosa M.“…Leishmania donovani, the causative agent of visceral leishmaniasis, contains an unusual heterodimeric DNA topoisomerase IB. …”
Publicado 2007
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5289“…Taken together, trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, onchocerciasis, intestinal nematode infections, Japanese encephalitis, dengue, and leprosy accounted for an estimated 177,000 deaths worldwide in 2002, mostly in sub-Saharan Africa, and about 20 million DALYs, or 1.3% of the global burden of disease and injuries. …”
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5290por Woelbing, Florian, Kostka, Susanna Lopez, Moelle, Katharina, Belkaid, Yasmine, Sunderkoetter, Cord, Verbeek, Sjef, Waisman, Ari, Nigg, Axel P., Knop, Juergen, Udey, Mark C., von Stebut, Esther“…Infected DCs efficiently stimulate CD4(−) and CD8(−) T cells and vaccinate against leishmaniasis. In contrast, complement receptor 3–dependent phagocytosis of L. major by macrophages (MΦ) leads exclusively to MHC class II–restricted antigen presentation to primed, but not naive, T cells, and no IL-12 production. …”
Publicado 2006
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5291por Brenchley, Rachel, Tariq, Humera, McElhinney, Helen, Szöőr, Balázs, Huxley-Jones, Julie, Stevens, Robert, Matthews, Keith, Tabernero, Lydia“…These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping sickness and cutaneous Leishmaniasis, respectively, that affect millions of people in the developing world. …”
Publicado 2007
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5292por von Stebut, Esther, Belkaid, Yasmine, Jakob, Thilo, Sacks, David L., Udey, Mark C.“…These results suggest that skin Mφ and DC are infected sequentially in cutaneous leishmaniasis and that they play distinct roles in the inflammatory and immune response initiated by L. major. …”
Publicado 1998
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5293por Silverman, J Maxwell, Chan, Simon K, Robinson, Dale P, Dwyer, Dennis M, Nandan, Devki, Foster, Leonard J, Reiner, Neil E“…To investigate secretion of potential effectors more broadly, we used quantitative mass spectrometry to analyze the protein content of conditioned medium collected from cultures of stationary-phase promastigotes of Leishmania donovani, an agent of visceral leishmaniasis. RESULTS: Analysis of leishmania conditioned medium resulted in the identification of 151 proteins apparently secreted by L. donovani. …”
Publicado 2008
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5294por Al-Jawabreh, Amer, Diezmann, Stephanie, Müller, Michaela, Wirth, Thierry, Schnur, Lionel F, Strelkova, Margarita V, Kovalenko, Dmitri A, Razakov, Shavkat A, Schwenkenbecher, Jan, Kuhls, Katrin, Schönian, Gabriele“…BACKGROUND: Leishmania (Leishmania) major, one of the agents causing cutaneous leishmaniasis (CL) in humans, is widely distributed in the Old World where different species of wild rodent and phlebotomine sand fly serve as animal reservoir hosts and vectors, respectively. …”
Publicado 2008
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5295por Campos, Fernanda Fraga, Rosa, Luiz Henrique, Cota, Betania Barros, Caligiorne, Rachel Basques, Teles Rabello, Ana Lúcia, Alves, Tânia Maria Almeida, Rosa, Carlos Augusto, Zani, Carlos Leomar“…These results suggest that cochlioquinones are attractive lead compounds that deserve further investigation aiming at developing new drugs to treat leishmaniasis. The findings also reinforce the role of endophytic fungi as an important source of compounds with potential to enter the pipeline for drug development against NTDs.…”
Publicado 2008
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5296“…BACKGROUND: Bodo saltans is a free-living kinetoplastid and among the closest relatives of the trypanosomatid parasites, which cause such human diseases as African sleeping sickness, leishmaniasis and Chagas disease. A B. saltans genome sequence will provide a free-living comparison with parasitic genomes necessary for comparative analyses of existing and future trypanosomatid genomic resources. …”
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5297por Bettiol, Esther, Samanovic, Marie, Murkin, Andrew S., Raper, Jayne, Buckner, Frederick, Rodriguez, Ana“…These results provide new candidate molecules for the development of treatments against Chagas disease and leishmaniasis.…”
Publicado 2009
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5298por Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Yang, Wei, González-Pacanowska, Dolores, Vidal, Antonio E.“…In Leishmania major, the causal agent of leishmaniasis, the APE1 homolog is the class II AP endonuclease LMAP. …”
Publicado 2009
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5299por Robbins, Gwen, Tripathy, V. Mushrif, Misra, V. N., Mohanty, R. K., Shinde, V. S., Gray, Kelsey M., Schug, Malcolm D.“…The presence and patterning of lesions was subject to a process of differential diagnosis for leprosy including treponemal disease, leishmaniasis, tuberculosis, osteomyelitis, and non-specific infection. …”
Publicado 2009
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5300por Peters, Nathan C., Kimblin, Nicola, Secundino, Nagila, Kamhawi, Shaden, Lawyer, Phillip, Sacks, David L.“…Numerous experimental vaccines have been developed to protect against the cutaneous and visceral forms of leishmaniasis caused by infection with the obligate intracellular protozoan Leishmania, but a human vaccine still does not exist. …”
Publicado 2009
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