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5341“…Common etiological pattern identified were Aplastic anemia 58(28.3%), Hematological malignancies 49 (23.9%), megaloblastic anemia 40 (19.5%), idiopathic thrombocytopenic purpura 16 (7.8%), iron deficiency anemia 9 (4.4%), hemolytic anemia 7 (3.41%), Visceral leishmaniasis 6 (2.93%), hypersplenism 5 (2.44%), malaria 5 (2.44%), anemia of chronic disorder 4 (1.95%), Myelodisplastic syndrome 3 (1.46%), Niemen pick disease 2 (0.97%) and Gaucher disease in 1(0.49%). …”
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5342por Rogers, Matthew B., Downing, Tim, Smith, Barbara A., Imamura, Hideo, Sanders, Mandy, Svobodova, Milena, Volf, Petr, Berriman, Matthew, Cotton, James A., Smith, Deborah F.“…Here, we use whole genome sequencing to investigate the frequency of sexual reproduction in Leishmania, by sequencing the genomes of 11 Leishmania infantum isolates from sand flies and 1 patient isolate in a focus of cutaneous leishmaniasis in the Çukurova province of southeast Turkey. …”
Publicado 2014
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5343por Ngure, Peter, Ng'ang'a, Zipporah, Kimutai, Albert, Kepha, Stella, Mong'are, Samuel, Ingonga, Johnnie, Tonui, Willy“…RESULTS: On vaccination with extracts of W. ugandensis subsp. ugandensis alone or as adjuvants when used in combination with Leishmania antigens, the hexane extract and the dichloromethane extract plus SLA stimulated moderate production of IFN-γ and low levels of IL-4.These mice were partially protected from cutaneous leishmaniasis as shown by the slow development of lesions and comparatively less parasite burdens. …”
Publicado 2014
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5344por Petropolis, Debora B., Rodrigues, Juliany C.F., Viana, Nathan B., Pontes, Bruno, Pereira, Camila F.A., Silva-Filho, Fernando C.“…Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. …”
Publicado 2014
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5345por De Queiroz, Aline Cavalcanti, Dias, Thays de Lima Matos Freire, Da Matta, Carolina Barbosa Brito, Cavalcante Silva, Luiz Henrique Agra, de Araújo-Júnior, João Xavier, de Araújo, Givanildo Bernardino, Moura, Flávia de Barros Prado, Alexandre-Moreira, Magna Suzana“…Data were collected in the cities of Colonia Leopoldina, Novo Lino, and União dos Palmares, Alagoas state, from patients with cutaneous leishmaniasis (Leishmania amazonensis) who use medicinal plants to treat this disease. …”
Publicado 2014
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5346por Camargos, Heverton Silva, Moreira, Rodrigo Alves, Mendanha, Sebastião Antonio, Fernandes, Kelly Souza, Dorta, Miriam Leandro, Alonso, Antonio“…The in vitro cytotoxicity of nerolidol was similar to that of miltefosine, and nerolidol has high hydrophobicity; thus, nerolidol might be used in drug delivery systems, such as lipid nanoparticles to treat leishmaniasis.…”
Publicado 2014
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5347por Vogl, Thomas, Eisenblätter, Michel, Völler, Tom, Zenker, Stefanie, Hermann, Sven, van Lent, Peter, Faust, Andreas, Geyer, Christiane, Petersen, Beatrix, Roebrock, Kirsten, Schäfers, Michael, Bremer, Christoph, Roth, Johannes“…Furthermore, S100A8/S100A9 can act as a very early and sensitive biomarker in experimental leishmaniasis for phagocyte activation linked to an effective Th1-response. …”
Publicado 2014
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5348por Malaviya, Paritosh, Hasker, Epco, Picado, Albert, Mishra, Mukesh, Geertruyden, Jean-Pierre Van, Das, Murari Lal, Boelaert, Marleen, Sundar, Shyam“…BACKGROUND: Visceral Leishmaniasis (VL) is a vector-borne infectious disease, caused by the protozoan Leishmania donovani, which is transmitted by phlebotomine sand flies. …”
Publicado 2014
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5349“…The search identified 650 clinical studies. Leishmaniasis, Arbovirus infection, and Dengue are the top three diseases by number of clinical studies. …”
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5350por Prati, Federica, Goldman-Pinkovich, Adele, Lizzi, Federica, Belluti, Federica, Koren, Roni, Zilberstein, Dan, Bolognesi, Maria Laura“…Leishmania donovani, the parasite that causes visceral leishmaniasis, is auxotrophic for arginine and lysine and has specific transporters (LdAAP3 and LdAAP7) to import these nutrients. …”
Publicado 2014
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5351por Corware, Karina, Yardley, Vanessa, Mack, Christopher, Schuster, Steffen, Al-Hassi, Hafid, Herath, Shanthi, Bergin, Philip, Modolell, Manuel, Munder, Markus, Müller, Ingrid, Kropf, Pascale“…Using an experimental model of visceral leishmaniasis, we show that following protein energy malnutrition, the increased parasite burden measured in the spleen of these mice coincided with increased arginase activity and that macrophages provide a more permissive environment for parasite growth. …”
Publicado 2014
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5352por Vasconcelos, Elton J. R., Nunes, Vinícius S., da Silva, Marcelo S., Segatto, Marcela, Myler, Peter J., Cano, Maria Isabel N.“…Here, we identify a candidate for the telomerase RNA component of Leishmania genus, which includes species that cause leishmaniasis, a neglected tropical disease. Merging a thorough computational screening combined with RNA-seq evidence, we mapped a non-coding RNA gene localized in a syntenic locus on chromosome 25 of five Leishmania species that shares partial synteny with both Trypanosoma brucei TER locus and a putative TER candidate-containing locus of Crithidia fasciculata. …”
Publicado 2014
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5353por Monteiro Tínel, Juliana Montezuma Barbosa, Benevides, Melina Fechine Costa, Frutuoso, Mércia Sindeaux, Rocha, Camila Farias, Arruda, Francisco Vassiliepe Sousa, Vasconcelos, Mayron Alves, Pereira-Junior, Francisco Nascimento, Cajazeiras, João Batista, do Nascimento, Kyria Santiago, Martins, Jorge Luiz, Teixeira, Edson Holanda, Cavada, Benildo Sousa, dos Santos, Ricardo Pires, Lima Pompeu, Margarida Maria“…Leishmaniasis is a vector-borne disease transmitted by phlebotomine sand fly. …”
Publicado 2014
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5354por Vasconcelos, Mariela Ferreira de, Cunha-Júnior, Edézio Ferreira da, Andrade-Neto, Valter Viana de, Siqueira, Larissa Moreira, d’Avila-Levy, Cláudia Masini, Moreth, Marcele, Cunico, Wilson, Souza, Marcus Vinícius Nora de, Gomes, Cláudia Regina Brandão, Torres-Santos, Eduardo Caio“…These results demonstrate that PMIC4 is a promising molecular scaffold, orally effective against experimental leishmaniasis.…”
Publicado 2014
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5355por Maleki-Ravasan, Naseh, Oshaghi, Mohammad Ali, Hajikhani, Sara, Saeidi, Zahra, Akhavan, Amir Ahmad, Gerami-Shoar, Mohsen, Shirazi, Mohammad Hasan, Yakhchali, Bagher, Rassi, Yavar, Afshar, Davoud“…METHODS: The microbial flora of gut and surrounding environmental of a laboratory strain of Phlebotomus papatasi, the main vector of Zoonotic Cutaneous Leishmaniasis (ZCL) in the old world, was investigated. …”
Publicado 2013
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5356por MAHMOUDVAND, Hossein, SHARIFIFAR, Fariba, SHARIFI, Iraj, EZATPOUR, Behrouz, FASIHI HARANDI, Majid, MAKKI, Mahsa Sadat, ZIA-ALI, Naser, JAHANBAKHSH, Sareh“…BACKGROUND: Leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. …”
Publicado 2014
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5357“…Co-infection with salmonella or hepatitis viruses B or C may confound the clinical picture of schistosomiasis, while the latter may have a negative impact on the course of other co-infections as malaria, leishmaniasis and HIV. Prevention of schistosomiasis is basically geared around education and periodic mass treatment, an effective vaccine being still experimental. …”
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5358por Ferreira, Daniela Guimarães Rocha, do Val Rezende, Paulo, Murao, Mitiko, Viana, Marcos Borato, de Oliveira, Benigna Maria“…In two cases, associated with visceral leishmaniasis, remission was achieved after treatment of the underlying infection. …”
Publicado 2014
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5359por Kolaczinski, Jan H, Muhammad, Nasir, Khan, Qaiser S, Jan, Zahoor, Rehman, Naveeda, Leslie, Toby J, Rowland, Mark“…In Pakistan-based Afghan refugee camps, this was attempted through shifting from indoor residual spraying (IRS) to the subsidized sale of insecticide-treated nets (ITNs) for prevention of malaria and anthroponotic cutaneous leishmaniasis (ACL). Here we outline the strategy and document the progress to provide guidance for replication of similar approaches in other chronic refugee situations. …”
Publicado 2004
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5360“…Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. …”
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