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5381por Ismail, Hanafy M., Kumar, Vijay, Singh, Rudra P., Williams, Christopher, Shivam, Pushkar, Ghosh, Ayan, Deb, Rinki, Foster, Geraldine M., Hemingway, Janet, Coleman, Michael, Coleman, Marlize, Das, Pradeep, Paine, Mark J. I.“…BACKGROUND: Indoor residual spraying (IRS) of DDT is used to control visceral leishmaniasis (VL) in India. However, the quality of spraying is severely compromised by a lack of affordable field assays to monitor target doses of insecticide. …”
Publicado 2016
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5382por Jackson, Andrew P., Otto, Thomas D., Aslett, Martin, Armstrong, Stuart D., Bringaud, Frederic, Schlacht, Alexander, Hartley, Catherine, Sanders, Mandy, Wastling, Jonathan M., Dacks, Joel B., Acosta-Serrano, Alvaro, Field, Mark C., Ginger, Michael L., Berriman, Matthew“…Trypanosomatids are important parasites and include the human pathogens Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., which in humans cause African trypanosomiasis, Chagas disease, and leishmaniasis, respectively. Genome comparison between trypanosomatids reveals that these parasites have evolved specialized cell-surface protein families, overlaid on a well-conserved cell template. …”
Publicado 2016
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5383por Lacerda, Ariane F., Pelegrini, Patrícia B., de Oliveira, Daiane M., Vasconcelos, Érico A. R., Grossi-de-Sá, Maria F.“…Africa, Asia, and Latin America are regions highly affected by endemic diseases, such as Leishmaniasis, Malaria, and Chagas’ disease. They are responsible for the death of 1000s of patients every year, as there is not yet a cure for them and the drugs used are inefficient against the pathogenic parasites. …”
Publicado 2016
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5384por Rabhi, Sameh, Rabhi, Imen, Trentin, Bernadette, Piquemal, David, Regnault, Béatrice, Goyard, Sophie, Lang, Thierry, Descoteaux, Albert, Enninga, Jost, Guizani-Tabbane, Lamia“…Understanding the strategies developed by the parasite to circumvent macrophage defense mechanisms and to survive within those cells help defining novel therapeutic approaches for leishmaniasis. We previously showed the formation of lipid droplets (LDs) in L. major infected macrophages. …”
Publicado 2016
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5385por Bhaumik, Soumyadeep, Karimkhani, Chante, Czaja, Christopher A., Williams, Hywel C., Rani, Monica, Nasser, Mona, Boyers, Lindsay N., Dmitruk, Sergei, Dellavalle, Robert P.“…Leprosy, trachoma, dengue, leishmaniasis, and Chagas disease representation was greater, while cysticercosis, human African trypanosomiasis, ascariasis, lymphatic filariasis, and hookworm representation was lower than DALY. …”
Publicado 2015
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5386por Akhoundi, Mohammad, Kuhls, Katrin, Cannet, Arnaud, Votýpka, Jan, Marty, Pierre, Delaunay, Pascal, Sereno, Denis“…Despite several hypotheses on the origin, evolution, and distribution of Leishmania and sandflies in the Old and New World, no consistent agreement exists regarding dissemination of the actors that play roles in leishmaniasis. For this purpose, we present here three centuries of research on sandflies and Leishmania descriptions, as well as a complete description of Leishmania and sandfly fossils and the emergence date of each Leishmania and sandfly group during different geographical periods, from 550 million years ago until now. …”
Publicado 2016
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5387por Kaur, Preet Kamal, Tripathi, Neha, Desale, Jayesh, Neelagiri, Soumya, Yadav, Shailendra, Bharatam, Prasad V., Singh, Sushma“…Ribose-5-phosphate isomerase B from Leishmania donovani (LdRpiB) is one of the potential drug targets against visceral leishmaniasis. In the present study, we have targeted several conserved amino acids for mutational analysis (i.e. …”
Publicado 2016
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5388por Ramos, Patrícia Karla, Carvalho, Karina Inácio, Rosa, Daniela Santoro, Rodrigues, Ana Paula, Lima, Luciana Vieira, Campos, Marliane Batista, Gomes, Claudia Maria C., Laurenti, Márcia Dalastra, Corbett, Carlos Eduardo, Silveira, Fernando Tobias“…The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi infection in Amazonian Brazil was recently reviewed based on clinical, DTH, and IFAT (IgG) evaluations that identified five profiles: three asymptomatic (asymptomatic infection, AI; subclinical resistant infection, SRI; and indeterminate initial infection, III) and two symptomatic (symptomatic infection, SI; American visceral leishmaniasis, AVL; and subclinical oligosymptomatic infection, SOI). …”
Publicado 2016
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5389por Barhoumi, Walid, Fares, Wasfi, Cherni, Saifedine, Derbali, Mohamed, Dachraoui, Khalil, Chelbi, Ifhem, Ramalho-Ortigao, Marcelo, Beier, John C., Zhioua, Elyes“…The current spread of zoonotic visceral leishmaniasis (ZVL) throughout arid areas of Central Tunisia is a major public health concern. …”
Publicado 2016
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5390por Quintal, Amanda P. N., Borges, Bruna C., Brígido, Paula C., Silva, Rebecca T., Notário, Ana F., Santos, Marlus A., de Souza, Maria A., Nascimento, Fernanda G. O., Mundim, Antônio V., Costa, Guilherme M. J., Vasconcelos, André B., da Silva, Claudio V.“…BACKGROUND: Leishmaniasis causes alterations and lesions in the genital system, which leads to azoospermia and testicular atrophy in animals during the chronic phase of the infection. …”
Publicado 2016
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5391“…BACKGROUND: The Leishmania spp. protozoa, the causative agents of the “neglected” tropical disease leishmaniasis, are transmitted to mammals by sand fly vectors. …”
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5392por Aslan, Hamide, Oliveira, Fabiano, Meneses, Claudio, Castrovinci, Philip, Gomes, Regis, Teixeira, Clarissa, Derenge, Candace A., Orandle, Marlene, Gradoni, Luigi, Oliva, Gaetano, Fischer, Laurent, Valenzuela, Jesus G., Kamhawi, Shaden“…Canine leishmaniasis (CanL) is a chronic fatal disease of dogs and a major source of human infection through propagation of parasites in vectors. …”
Publicado 2016
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5393por Cohen, Philip R.“…RESULTS: Several vaccines—including bacillus Calmette-Guerin, hepatitis B, influenza, leishmaniasis, meningitis, pneumococcal, smallpox, tetanus (alone and in combination with diphtheria, pertussis, polio, Haemophilus influenza type B or plague and yellow fever), and varicella-zoster—have been associated with post-vaccination site reactions. …”
Publicado 2016
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5394por Rahola, Nil, Henni, Leila Hadj, Obame, Judicael, Ayala, Diego, Makanga, Boris Kevin, Lehrter, Véronique, Izri, Arezki, Paupy, Christophe, Depaquit, Jérôme“…Despite a potential role in Leishmania major leishmaniasis transmission in Mali, no molecular studies and only few morphological studies have addressed relationships between species of Spelaeomyia. …”
Publicado 2016
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5395por Lima, Leonardo H. G. de M., Mesquita, Marcelo R., Skrip, Laura, de Souza Freitas, Moisés T., Silva, Vladimir C., Kirstein, Oscar D., Abassi, Ibrahim, Warburg, Alon, Balbino, Valdir de Q., Costa, Carlos H. N.“…We studied plant feeding of Lutzomyia longipalpis sand flies, known vectors of Leishmania infantum/chagasi parasites, in a Brazilian city endemic with visceral leishmaniasis. The DNA barcode technique was applied to identify plant food source of wild-caught L. longipalpis using specific primers for a locus from the chloroplast genome, ribulose diphosphate carboxylase. …”
Publicado 2016
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5396“…BACKGROUND: Leishmaniasis is a neglected tropical parasitic diseases affecting millions of people around the globe. …”
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5397por Sajjadi, Seyed Ebrahim, Eskandarian, Abbas-Ali, Shokoohinia, Yalda, Yousefi, Hosein-Ali, Mansourian, Marjan, Asgarian-Nasab, Hasan, Mohseni, Negar“…Leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of Leishmania species and makes enormous mortality and morbidity. …”
Publicado 2016
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5398por Medina, Lilian S., Souza, Bruno Araújo, Queiroz, Adriano, Guimarães, Luiz Henrique, Lima Machado, Paulo Roberto, M Carvalho, Edgar, Wilson, Mary Edythe, Schriefer, Albert“…In the current study we evaluate the polymorphism of gp63 in Leishmania (Viannia) braziliensis isolated from two sets of American tegumentary leishmaniasis (ATL) cases from Corte de Pedra, Brazil, including 35 cases diagnosed between 1994 and 2001 and 6 cases diagnosed between 2008 and 2011. …”
Publicado 2016
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5399por Wyllie, Susan, Roberts, Adam J., Norval, Suzanne, Patterson, Stephen, Foth, Bernardo J., Berriman, Matthew, Read, Kevin D., Fairlamb, Alan H.“…Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment of visceral leishmaniasis. Using a combination of quantitative proteomics and whole genome sequencing of susceptible and drug-resistant parasites we identified a putative NAD(P)H oxidase as the activating nitroreductase (NTR2). …”
Publicado 2016
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5400por Alirol, Emilie, Horie, Ninon Seiko, Barbé, Barbara, Lejon, Veerle, Verdonck, Kristien, Gillet, Philippe, Jacobs, Jan, Büscher, Philippe, Kanal, Basudha, Bhattarai, Narayan Raj, El Safi, Sayda, Phe, Thong, Lim, Kruy, Leng, Long, Lutumba, Pascal, Mukendi, Deby, Bottieau, Emmanuel, Boelaert, Marleen, Rijal, Suman, Chappuis, François“…The NIDIAG clinical research consortium focused on potentially severe and treatable infections and therefore targeted the following conditions as differential diagnosis of persistent fever: visceral leishmaniasis (VL), human African trypanosomiasis (HAT), enteric (typhoid and paratyphoid) fever, brucellosis, melioidosis, leptospirosis, malaria, tuberculosis, amoebic liver abscess, relapsing fever, HIV/AIDS, rickettsiosis, and other infectious diseases (e.g., pneumonia). …”
Publicado 2016
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