-
5441por dos Santos Sales, Valterlúcio, Monteiro, Álefe Brito, Delmondes, Gyllyandeson de Araújo, do Nascimento, Emmily Petícia, Sobreira Dantas Nóbrega de Figuêiredo, Francisco Rodolpho, de Souza Rodrigues, Cristina Kelly, Evangelista de Lacerda, Josefa Fernanda, Fernandes, Cícera Norma, Barbosa, Maysa de Oliveira, Brasil, Adamo Xenofonte, Tintino, Saulo Relison, Vega Gomez, Maria Celeste, Coronel, Cathia, Melo Coutinho, Henrique Douglas, Martins da Costa, José Galberto, Bezerra Felipe, Cícero Francisco, Alencar de Menezes, Irwin Rose, Kerntopf, Marta Regina“…With the increase of neglected diseases such as leishmaniasis and Chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5442por Nourizadeh, Ezzat, Zargar, Seyed Jalal, Alimohammadian, Mohammad Hossein, Ajdary, Soheila, Mahdavi, Mahdi“…OBJECTIVE(S): Leishmaniasis is endemic in 88 countries. Amastigote forms of Leishmania are experts at exploiting host cell processes to establish infection. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5443por Habib, Samar, El Andaloussi, Abdeljabar, Elmasry, Khaled, Handoussa, Aya, Azab, Manar, Elsawey, Aliaa, Al-Hendy, Ayman, Ismail, Nahed“…Leishmania donovani is a causative pathogen of potentially fatal visceral leishmaniasis (VL). Therapeutic agents are available; however, their use is limited because of high cost, serious side effects, and development of antimicrobial resistance. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5444por KARIYAWASAM, K. K. G. D. U. L., SELVAPANDIYAN, A., SIRIWARDANA, H. V. Y. D., DUBE, A., KARUNANAYAKE, P., SENANAYAKE, S. A. S. C., DEY, R., GANNAVARAM, S., NAKHASI, H. L., KARUNAWEERA, N. D.“…The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L. donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5445por Mirahmadi, Hadi, Rezaee, Nasrin, Mehravaran, Ahmad, Heydarian, Peyman, Raeghi, Saber“…AIM: Cutaneous leishmaniasis (CL) is one of the most important health problems that are capable of involving both tropical and subtropical areas, especially in Iran. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5446“…Chronologically, some of the major contributions of Spanish HIV research are being in the field of tuberculosis, toxoplasmosis, leishmaniasis, HIV variants including HIV-2, drug resistance, pharmacology, antiretroviral drug-related toxicities, coinfection with viral hepatitis, design and participation in clinical trials with antiretrovirals, immunopathogenesis, ageing, and vaccine development.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5447por Fernandez-Prada, Christopher, Sharma, Mansi, Plourde, Marie, Bresson, Eva, Roy, Gaétan, Leprohon, Philippe, Ouellette, Marc“…Increasing drug resistance towards first line antimony-derived compounds has forced the introduction of novel therapies in leishmaniasis endemic areas including amphotericin B and miltefosine. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5448“…Mice are valuable experimental model for visceral leishmaniasis. METHODS: BALB/c mice infected with H. polygyrus (200 third-stage larvae, L3) were subsequently infected seven days later with Leishmania infantum (10(7) promastigotes) with the aim of determining the effect of the overinfection on the host response to the primary infection with the helminth. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5449por Cassan, Cécile, Diagne, Christophe A., Tatard, Caroline, Gauthier, Philippe, Dalecky, Ambroise, Bâ, Khalilou, Kane, Mamadou, Niang, Youssoupha, Diallo, Mamoudou, Sow, Aliou, Brouat, Carine, Bañuls, Anne-Laure“…Altogether, these data show that R. rattus is a carrier of both parasites and could be responsible for the emergence of new foci of cutaneous leishmaniasis, or for the transmission of atypical human trypanosomiasis in Senegal.…”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5450por Hefnawy, Aya, Cantizani, Juan, Peña, Imanol, Manzano, Pilar, Rijal, Suman, Dujardin, Jean-Claude, De Muylder, Geraldine, Martin, Julio“…The growing drug resistance (DR) raises major concerns for the control of visceral leishmaniasis (VL), a neglected disease lethal in 95 percent of the cases if left untreated. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5451por Zadeh Mehrizi, Tahereh, Shafiee Ardestani, Mehdi, Haji Molla Hoseini, Mostafa, Khamesipour, Ali, Mosaffa, Nariman, Ramezani, Amitis“…Regarding the antiparasitic effects of Betulinic acid (B) against Leishmaniasis, it was loaded into nanochitosan (K) for the first time in order to improve its therapeutic effects and decrease its side effects for the treatment of Leishmania major-infected Balb/c mice. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5452“…Betulin derivatives have been proven effective in vitro against Leishmania donovani amastigotes, which cause visceral leishmaniasis. Identifying the molecular targets and molecular mechanisms underlying their action is a currently an unmet challenge. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5453por Arish, Mohd, Husein, Atahar, Ali, Rahat, Tabrez, Shams, Naz, Farha, Ahmad, Mohammad Zulfazal, Rub, Abdur“…CONCLUSIONS: Our overall study not only reports the significant role of S1P signaling during L. donovani infection but also provides a novel platform for the development of new drugs against Leishmaniasis.…”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5454por Zivdari, Masoomeh, Hejazi, Seyed Hossein, Mirhendi, Seyed Hossein, Jafari, Reza, Rastegar, Hassan-Ali, Abtahi, Seyed Mohammad“…BACKGROUND: Cutaneous leishmaniasis is one of the most important public health problems in many developing countries. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5455por von Dohlen, Alexa Rosypal, Cheathem, Nautica, Tiwari, Keshaw, Sharma, Ravindra Nath“…The rats could play an important role in the transmission of leishmaniasis to humans and other animals in Grenada.…”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5456“…BACKGROUND: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5457por Davenport, Bennett J., Martin, Casey G., Beverley, Stephen M., Orlicky, David J., Vazquez-Torres, Andres, Morrison, Thomas E.“…Leishmania species are sand fly-transmitted protozoan parasites that cause leishmaniasis, neglected tropical diseases that affect millions of people. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5458por Cruz-Bustos, Teresa, Ibarrola-Vannucci, Ana Karina, Díaz-Lozano, Isabel, Ramírez, José Luis, Osuna, A.“…BACKGROUND: Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5459por Bell, Melissa J., Sedda, Luigi, Gonzalez, Mikel A., de Souza, Cristian F., Dilger, Erin, Brazil, Reginaldo P., Courtenay, Orin, Hamilton, James G. C.“…In South America, the Protist parasite that causes visceral leishmaniasis, a potentially fatal human disease, is transmitted by blood-feeding female Lutzomyia longipalpis sand flies. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5460por Berry, Sarah L., Walker, Karen, Hoskins, Clare, Telling, Neil D., Price, Helen P.“…Cutaneous leishmaniasis is a neglected tropical disease characterized by disfiguring skin lesions. …”
Publicado 2019
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto