“…BACKGROUND: Leishmaniasis is a vector-borne neglected disease. Inside the natural sand fly vector, the promastigote forms of Leishmania undergo a series of extracellular developmental stages to reach the infectious stage, the metacyclic promastigote. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Leishmania donovani, the causative agent of visceral leishmaniasis, on the contrary alters immune response of the host macrophage by a variety of complex mechanisms to promote anti‐inflammatory response essential for the survival of the parasite. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Other high priority zoonotic diseases of wildlife origin which could affect both livestock and humans include influenza, Nipah, Japanese encephalitis, rabies, plague, leptospirosis, anthrax and leishmaniasis. Continuous monitoring of India's extensively diverse and dispersed wildlife is challenging, but their use as indicators should facilitate efficient and rapid disease-outbreak response across the region and occasionally the globe. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Low-income countries are particularly affected by lymphatic filariasis, leishmaniasis, schistosomiasis, Buruli ulcer, cholera, cysticercosis, dracunculiasis, foodborne trematode infections, hydatidosis, soil-transmitted helminthiasis (ascariasis, trichuriasis, hookworm diseases), trachoma, sleeping sickness, onchocerciasis, Chagas disease, dengue and others. …”
Enlace del recurso
Enlace del recurso

“…A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The present data not only demonstrate that up-regulation of HDAC1 and epigenetic silencing of host cell defense genes is essential for L. donovani infection but also provides novel therapeutic strategies against leishmaniasis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These infections are comprised of, but not limited to, toxoplasmosis, malaria, leishmaniasis and any one of a wide variety of helminthic infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We aimed to design a suitable construction for a Leishmania major DNA vaccine and evaluate the protective efficacy of it as a candidate for DNA vaccine against cutaneous leishmaniasis in BALB/c mice. METHODS: This experimental study was conducted in Tehran City, Iran, between April 20, 2015 and May 30, 2016. …”
Enlace del recurso
Enlace del recurso

“…The results suggest that limonoids have potential as drug candidates for the development of new treatments against trypanosomiasis and leishmaniasis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-020-01408-7) contains supplementary material, which is available to authorized users.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Leishmania infantum is a flagellated protozoan and one of the main causative agents of visceral leishmaniasis. This disease usually affects the human reticuloendothelial system, can cause death and available therapies may lead to serious side effects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, salivary proteins can influence cutaneous leishmaniasis disease outcome, highlighting the potential of the salivary components to be used as a vaccine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Visceral leishmaniasis (VL) is a life-threatening disease caused by the protozoa Leishmania donovani and L. infantum. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Eighty-six samples were collected from 46 animals in an endemic region of visceral leishmaniasis (VL). MLMT was performed for 38 spleen samples and 48 L. infantum cultures isolated from different tissues. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Leishmania species are responsible for a broad spectrum of diseases, denominated Leishmaniasis, affecting over 12 million people worldwide. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Visceral leishmaniasis caused by the protozoan Leishmania infantum is a zoonosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Data concerning dogs, their environment, and their owners’ knowledge of leishmaniasis were collected using a questionnaire. To determine RFs for contact with the parasite, univariate statistical analysis based on chi-squared and Fisher’s exact tests, followed by logistic regression, was used. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Leishmania tropica is one of the main causative agents of cutaneous leishmaniasis (CL). Population structures of L. tropica appear to be genetically highly diverse. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Infectious diseases prevalent in the tropics, such as HIV, leishmaniasis, arboviruses, and malaria, represent conditions with the potential to cause false-positive results with these tests, which significantly compromises their specificity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this work, we focused on the DHS enzymes from Brugia malayi and Leishmania major, the causative agents of lymphatic filariasis and cutaneous leishmaniasis, respectively. To enable B. malayi (Bm)DHS for future target-based drug discovery programs, we determined its crystal structure bound to cofactor NAD(+). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These synthesized nanoparticles exhibit superior antimicrobial, anticancer, larvicidal, leishmaniasis, wound healing, antioxidant, and as a sensor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso