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  1. 5821
    “…With the global reach of the Neglected Tropical Disease leishmaniasis increasing, coupled with a tiny armory of therapeutics which all have problems with resistance, cost, toxicity and/or administration, the validation of new drug targets in the causative insect vector borne protozoa Leishmania spp is more important than ever. …”
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    Genome deletions to overcome the directed loss of gene function in Leishmania
  2. 5822
    “…IMPORTANCE Disease manifestations of cutaneous leishmaniasis (CL) range from self-healing cutaneous lesions to chronic forms of the disease, depending on the infecting Leishmania sp. and host immune protection. …”
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    Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes
  3. 5823
    “…BACKGROUND: Leishmaniasis being a local disease, as kala-azar this particular form is a visceral form. …”
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    A Case Report of Two Kala-Azar Cases in China Diagnosed by Metagenomic Next-Generation Sequencing
  4. 5824
    “…Collectively, these results suggest that leishmania parasites might hijack the cGAS-STING-TBK1 signaling pathway to their own advantage and the TBK1 inhibitor amlexanox could be of interest as a candidate drug in treatment of cutaneous leishmaniasis.…”
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    Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia
  5. 5825
    “…BACKGROUND: Leishmania infantum infection can result in serious vector‐borne zoonotic disease such as visceral leishmaniasis. The objectives of the study were to estimate the seroprevalence and associated risk factors in Weliso, Ambo, and Ejaji towns in the Southwest and West Shewa zones, Oromia, Ethiopia. …”
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    High seroprevalence of Leishmania infantum infection in dogs and its associated risk factors in selected towns of Southwest and West Shewa zones of Oromia, Ethiopia
  6. 5826
    “…Leishmania infantum is the agent of visceral leishmaniasis in the Mediterranean basin. It is transmitted by sandflies of the subgenus Larroussius. …”
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    MALDI-TOF MS Limits for the Identification of Mediterranean Sandflies of the Subgenus Larroussius, with a Special Focus on the Phlebotomus perniciosus Complex
  7. 5827
    “…When the infundibulum was compared with the ampulla and isthmus, it was found that the up-regulated genes were enriched in the lysosome, phagosome, staphylococcus aureus infection, and leishmaniasis pathway. When the isthmus was compared with the ampulla and infundibulum, the up-regulated genes were present in the apoptosis pathway, oxidative phosphorylation, and viral myocarditis pathway. …”
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    Identification of key genes and biological pathways in different parts of yak oviduct based on transcriptome analysis
  8. 5828
    “…A wide range of protozoan pathogens either transmitted by vectors (Plasmodium, Babesia, Leishmania and Trypanosoma), by contaminated food or water (Entamoeba and Giardia), or by sexual contact (Trichomonas) invade various organs in the body and cause prominent human diseases, such as malaria, babesiosis, leishmaniasis, trypanosomiasis, diarrhea, and trichomoniasis. …”
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    Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens
  9. 5829
    “…Cancer and parasitic diseases, such as leishmaniasis and Chagas disease, share similarities that allow the co-development of new antiproliferative agents as a strategy to quickly track the discovery of new drugs. …”
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    A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines
  10. 5830
    “…This study revealed that V. brasiliana and its metabolites are potential sources of lead compounds for drugs for leishmaniasis treatment.…”
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    Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)
  11. 5831
    “…Methods: Skin lesion biopsies were obtained from patients with cutaneous leishmaniasis (CL). Biopsy specimens of 2 mm (n = 10) and 3 mm (n = 59) were preserved in Allprotect® reagent, and 4 mm biopsies in OCT (n = 54). …”
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    Quality parameters for RNA preparations from biopsies of ulcerated human skin
  12. 5832
    “…Their in vitro leishmanicidal activity against visceral (L. donovani) and cutaneous (L. amazonensis) leishmaniasis was evaluated finding that compounds 5bc (IC(50) = 30.87 μM, SI > 10.17) and 5bd (IC(50) = 16.87 μM, SI > 10.67) were approximately 6-fold more selective than the drug of reference (miltefosine) in in vitro assays against L. amazonensis promastigotes. …”
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    Prediction of Antileishmanial Compounds: General Model, Preparation, and Evaluation of 2-Acylpyrrole Derivatives
  13. 5833
    “…Given the lack of investments, structure, and difficulty of metabolite isolation, promising natural product studies do not progress to preclinical studies, such as pharmacokinetics. 2′-Hydroxyflavanone (2HF) is a flavonoid that has shown promising results in different types of cancer and leishmaniasis. For accurate quantification of 2HF in BALB/c mouse blood, a validated HPLC-MS/MS method was developed. …”
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    Analysis of 2′-hydroxyflavanone (2HF) in mouse whole blood by HPLC–MS/MS for the determination of pharmacokinetic parameters
  14. 5834
    “…Vaccination with live attenuated Leishmania parasites such as centrin deleted Leishmania donovani (LdCen(−/−)) against visceral leishmaniasis has been reported extensively. The protection induced by LdCen(−/−) parasites was mediated by both CD4(+) and CD8(+) T cells. …”
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    Deletion of MIF gene from live attenuated LdCen(−/−) parasites enhances protective CD4(+) T cell immunity
  15. 5835
    “…Biological function analysis showed 12, 19, and 12 GO entries related to biological processes, cell components and molecular functions, respectively. 43 KEGG pathways were identified, of which the most significant categories were terpenoid backbone biosynthesis, TNF signaling pathway and leishmaniasis. The component-target-disease network diagram revealed that the essential oil compositions in leaves of C. grandis ‘Tomentosa’ could treat tumors, immune diseases, neurodegenerative diseases and respiratory diseases, which were highly related to CHRM1, PTGS2, CASP3, MAP2K1 and CDC25B. …”
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    Analysis of Pharmacological Activities and Mechanisms of Essential Oil in Leaves of C. grandis ‘Tomentosa’ by GC-MS/MS and Network Pharmacology
  16. 5836
    “…IMPORTANCE Dendritic cells (DCs) play a key role in initiating T cell-mediated protective immunity against visceral leishmaniasis (VL), the second most lethal parasitic disease in the world. …”
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    Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor 2 Expression via Transforming Growth Factor-β
  17. 5837
    “…Background: Leishmaniasis results in a wide spectrum of clinical manifestations, ranging from skin lesions at the site of infection to disseminated lesions in internal organs, such as the spleen and liver. …”
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    Leishmania infection alters macrophage and dendritic cell migration in a three-dimensional environment
  18. 5838
    “…Leishmaniasis, a disease caused by parasites of Leishmania spp., endangers more than 1 billion people living in endemic countries and has three clinical forms: cutaneous, mucocutaneous, and visceral. …”
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    Functionally distinct regions of the locus Leishmania major response 15 control IgE or IFNγ level in addition to skin lesions
  19. 5839
    “…Leishmaniasis is a complex disease caused by infection with different Leishmania parasites. …”
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    (-)-5-Demethoxygrandisin B a New Lignan from Virola surinamensis (Rol.) Warb. Leaves: Evaluation of the Leishmanicidal Activity by In Vitro and In Silico Approaches
  20. 5840
    “…There was no cross-reaction in patient’s samples with visceral leishmaniasis, tuberculosis and other mycobacteriosis for both peptides. …”
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    HSP60 mimetic peptides from Mycobacterium leprae as new antigens for immunodiagnosis of Leprosy
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