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5881por Nico, Dirlei, Gomes, Daniele Crespo, Palatnik-de-Sousa, Iam, Morrot, Alexandre, Palatnik, Marcos, Palatnik-de-Sousa, Clarisa Beatriz“…Collectively, our multifunctional analysis disclosed that immunotherapeutic protection improved as the CD4 responses progressed from 1+ to 2+, in the case of the F1 and F3 vaccines, and as the CD8 responses changed qualitatively from 1+ to 3+, mainly in the case of the F1 vaccine, providing new correlates of immunotherapeutic protection against cutaneous leishmaniasis in mice based on T-helper TH1 and CD8(+) mediated immune responses.…”
Publicado 2014
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5882por Fukutani, Kiyoshi F, Figueiredo, Virgínia, Celes, Fabiana S, Cristal, Juqueline R, Barral, Aldina, Barral-Netto, Manoel, de Oliveira, Camila I“…BACKGROUND: Visceral Leishmaniasis is endemic to Brazil, where it is caused by Leishmania infantum (syn. …”
Publicado 2014
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5883por Lemma, Wossenseged, Tekie, Habte, Balkew, Meshesha, Gebre-Michael, Teshome, Warburg, Alon, Hailu, Asrat“…BACKGROUND: Kafta Humera lowlands are endemic for kala-azar (visceral leishmaniasis). These lowlands are characterized by black clay soil which is used for growing sesame, sorghum and cotton for commercial purposes. …”
Publicado 2014
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5884por Hitakarun, Atitaya, Tan-ariya, Peerapan, Siripattanapipong, Suradej, Mungthin, Mathirut, Piyaraj, Phunlerd, Naaglor, Tawee, Siriyasatien, Padet, Tiwananthagorn, Saruda, Leelayoova, Saovanee“…BACKGROUND: Leishmania siamensis, a newly identified species, has been reported as a causative agent of leishmaniasis in Thailand. This organism has been identified and genetically characterized using PCR techniques based on several target genes. …”
Publicado 2014
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5885por Faria, Marilia S., Calegari-Silva, Tereza C., de Carvalho Vivarini, Aislan, Mottram, Jeremy C., Lopes, Ulisses Gazos, Lima, Ana Paula C. A.“…In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. …”
Publicado 2014
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5886por Waugh, Barnali, Ghosh, Ambarnil, Bhattacharyya, Dhananjay, Ghoshal, Nanda, Banerjee, Rahul“…BACKGROUND: Leishmaniasis,a broad spectrum of diseases caused by several sister species of protozoa belonging to family trypanosomatidae and genus leishmania , generally affects poorer sections of the populace in third world countries. …”
Publicado 2014
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5887“…BACKGROUND: In areas endemic for visceral leishmaniasis (VL), the majority of infected hosts remain asymptomatic but potentially infectious to biting sand flies. …”
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5888por Hu, Ricardo V. P. F., Straetemans, Masja, Kent, Alida D., Sabajo, Leslie O. A., de Vries, Henry J. C., Lai A Fat, Rudy F. M.“…BACKGROUND: Standard treatment of cutaneous leishmaniasis (CL) in Suriname entails three injections of pentamidine isethionate (PI) 4 mg/kg per injection in 7 days (7 day regimen). …”
Publicado 2015
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5889por Cavalcanti, Amanda S., Ribeiro-Alves, Marcelo, Pereira, Luiza de O. R., Mestre, Gustavo Leandro, Ferreira, Anna Beatriz Robottom, Morgado, Fernanda N., Boité, Mariana C., Cupolillo, Elisa, Moraes, Milton O., Porrozzi, Renato“…Canine Visceral Leishmaniasis (CVL) shares many aspects with the human disease and dogs are considered the main urban reservoir of L. infantum in zoonotic VL. …”
Publicado 2015
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5890por Pinto, Erika Gracielle, Antoniazzi, Marta Maria, Jared, Carlos, Tempone, Andre Gustavo“…BACKGROUND: Among the tropical parasitic diseases, those caused by protozoans are considered a challenge to public health, being represented by leishmaniasis and Chagas disease. In view of the low effectiveness and toxicity of the current therapy, animal venoms such as amphibian secretions have been used as a promising source of new drug prototypes. …”
Publicado 2014
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5891por Hotez, Peter J., Bottazzi, Maria Elena, Strych, Ulrich, Chang, Li-Yen, Lim, Yvonne A. L., Goodenow, Maureen M., AbuBakar, Sazaly“…Intestinal protozoan infections are widespread, while leishmaniasis has emerged in Thailand, and zoonotic malaria (Plasmodium knowlesi infection) causes severe morbidity in Malaysia. …”
Publicado 2015
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5892por Rohousova, Iva, Talmi-Frank, Dalit, Kostalova, Tatiana, Polanska, Nikola, Lestinova, Tereza, Kassahun, Aysheshm, Yasur-Landau, Daniel, Maia, Carla, King, Roni, Votypka, Jan, Jaffe, Charles L., Warburg, Alon, Hailu, Asrat, Volf, Petr, Baneth, Gad“…BACKGROUND: Human visceral leishmaniasis caused by Leishmania donovani is considered an anthroponosis; however, Leishmania-infected animals have been increasingly reported in L. donovani foci, and the role of these animals as reservoirs for human L. donovani infection remains unclear. …”
Publicado 2015
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5893por Tomás-Pérez, Míriam, Hide, Mallorie, Riera, Cristina, Montoya, Liliana, Bañuls, Anne-Laure, Ribera, Esteve, Portús, Montserrat, Fisa, Roser“…BACKGROUND: Leishmania infantum is the main etiological agent of both visceral and cutaneous clinical forms of leishmaniasis in the Mediterranean area. Leishmania/HIV coinfection in this area is characterized by a chronic course and frequent recurrences of clinical episodes. …”
Publicado 2015
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5894por de Souza Freitas, Moises Thiago, Ríos-Velasquez, Claudia Maria, Costa, César Raimundo Lima, Figueirêdo, Carlos Alberto Santiago, Aragão, Nádia Consuelo, da Silva, Lidiane Gomes, de Aragão Batista, Marcus Vinicius, Balbino, Teresa Cristina Leal, Pessoa, Felipe Arley Costa, de Queiroz Balbino, Valdir“…BACKGROUND: In South America, Lutzomyia umbratilis is the main vector of Leishmania guyanensis, one of the species involved in the transmission of American tegumentary leishmaniasis. In Brazil, L. umbratilis has been recorded in the Amazon region, and in the state of Pernambuco, Northeastern region, where an isolated population has been identified. …”
Publicado 2015
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5895por Marzouki, Soumaya, Kammoun-Rebai, Wafa, Bettaieb, Jihene, Abdeladhim, Maha, Hadj Kacem, Saoussen, Abdelkader, Rania, Gritli, Sami, Chemkhi, Jomaa, Aslan, Hamide, Kamhawi, Shaden, Ben Salah, Afif, Louzir, Hechmi, Valenzuela, Jesus G., Ben Ahmed, Melika“…CONCLUSIONS/SIGNIFICANCE: Our data indicate that rPpSP32 constitutes a useful epidemiological tool to monitor the spatial distribution of P. papatasi in a particular region, to direct control measures against zoonotic cutaneous leishmaniasis, to assess the efficiency of vector control interventions and perhaps to assess the risk of contracting the disease.…”
Publicado 2015
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5896por Gesto, João Silveira Moledo, Rivas, Gustavo Bueno da Silva, Pavan, Marcio Galvão, Meireles-Filho, Antonio Carlos Alves, Amoretty, Paulo Roberto de, Souza, Nataly Araújo de, Bruno, Rafaela Vieira, Peixoto, Alexandre Afranio“…The sand fly Lutzomyia longipalpis is the main vector of visceral leishmaniasis in America and concentrates its activity around dusk. …”
Publicado 2015
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5897por Allison, Annabel, Edwards, Tansy, Omollo, Raymond, Alves, Fabiana, Magirr, Dominic, E. Alexander, Neal D.“…BACKGROUND: Visceral leishmaniasis (VL) is a parasitic disease transmitted by sandflies and is fatal if left untreated. …”
Publicado 2015
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5898por Markikou-Ouni, Wafa, Drini, Sima, Bahi-Jaber, Narges, Chenik, Mehdi, Meddeb-Garnaoui, Amel“…However, the reduced ability of LipESP-stimulated DCs and monocytes to respond to lipopolysaccharide (LPS) that can be observed during human leishmaniasis, suggests that under certain circumstances LipESP may play a role in disease progression.…”
Publicado 2015
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5899por de Vlas, Sake J., Stolk, Wilma A., le Rutte, Epke A., Hontelez, Jan A. C., Bakker, Roel, Blok, David J., Cai, Rui, Houweling, Tanja A. J., Kulik, Margarete C., Lenk, Edeltraud J., Luyendijk, Marianne, Matthijsse, Suzette M., Redekop, William K., Wagenaar, Inge, Jacobson, Julie, Nagelkerke, Nico J. D., Richardus, Jan H.“…Five NTDs (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths and trachoma) are to be controlled by preventive chemotherapy (PCT), and four (Chagas’ disease, human African trypanosomiasis, leprosy and visceral leishmaniasis) by innovative and intensified disease management (IDM). …”
Publicado 2016
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5900“…In East Africa, Phlebotomus orientalis is the main vector of Leishmania donovani, a trypanosomatid parasite causing visceral leishmaniasis. We tested recombinant salivary proteins derived from Ph. orientalis saliva to study exposure of domestic animals to this sand fly species. …”
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