-
5901por Benítez, Diego, Medeiros, Andrea, Fiestas, Lucía, Panozzo-Zenere, Esteban A., Maiwald, Franziska, Prousis, Kyriakos C., Roussaki, Marina, Calogeropoulou, Theodora, Detsi, Anastasia, Jaeger, Timo, Šarlauskas, Jonas, Peterlin Mašič, Lucíja, Kunick, Conrad, Labadie, Guillermo R., Flohé, Leopold, Comini, Marcelo A.“…BACKGROUND: The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)(2)], a low molecular mass cosubstrate absent in the host. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5902por Baneth, Gad, Nachum-Biala, Yaarit, Shabat Simon, Maytal, Brenner, Ori, Gaier, Sarit, Rojas, Alicia, Yasur-Landau, Daniel“…BACKGROUND: Leishmania major is a main cause of cutaneous leishmaniasis in humans in an area that stretches from India through Central Asia, the Middle East, to North and West Africa. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5903por Houweling, Tanja A. J., Karim-Kos, Henrike E., Kulik, Margarete C., Stolk, Wilma A., Haagsma, Juanita A., Lenk, Edeltraud J., Richardus, Jan Hendrik, de Vlas, Sake J.“…We describe within-country socioeconomic inequalities in nine NTDs listed in the London Declaration for intensified control and/or elimination: lymphatic filariasis (LF), onchocerciasis, schistosomiasis, soil-transmitted helminthiasis (STH), trachoma, Chagas’ disease, human African trypanosomiasis (HAT), leprosy, and visceral leishmaniasis (VL). METHODOLOGY: We conducted a systematic literature review, including publications between 2004–2013 found in Embase, Medline (OvidSP), Cochrane Central, Web of Science, Popline, Lilacs, and Scielo. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5904por Gannavaram, Sreenivas, Bhattacharya, Parna, Ismail, Nevien, Kaul, Amit, Singh, Rakesh, Nakhasi, Hira L.“…No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several antileishmanial vaccine formulations have been tested in various animal models, including genetically modified live-attenuated parasite vaccines. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5905“…This observation brings strength to our previous observation on host directed therapeutic application of liposomal cholesterol in experimental visceral leishmaniasis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5906por Bufalari, Antonello, Maggio, Chiara, Moretti, Giulia, Crovace, Alberto, Stefanetti, Valentina, Straubinger, Reinhard Konrad, Passamonti, Fabrizio“…The cause of the progression of the joint C. guilliermondii infection remains unclear but it may be associated with leishmaniasis or intra-articular corticosteroid injections. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5907por Abdeladhim, Maha, V. Coutinho-Abreu, Iliano, Townsend, Shannon, Pasos-Pinto, Silvia, Sanchez, Laura, Rasouli, Manoochehr, B. Guimaraes-Costa, Anderson, Aslan, Hamide, Francischetti, Ivo M. B., Oliveira, Fabiano, Becker, Ingeborg, Kamhawi, Shaden, Ribeiro, Jose M. C., Jochim, Ryan C., Valenzuela, Jesus G.“…BACKGROUND: Sand fly saliva has been shown to have proteins with potent biological activities, salivary proteins that can be used as biomarkers of vector exposure, and salivary proteins that are candidate vaccines against different forms of leishmaniasis. Sand fly salivary gland transcriptomic approach has contributed significantly to the identification and characterization of many of these salivary proteins from important Leishmania vectors; however, sand fly vectors in some regions of the world are still neglected, as Bichromomyia olmeca (formerly known as Lutzomyia olmeca olmeca), a proven vector of Leishmania mexicana in Mexico and Central America. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5908por e Silva, Rafael de Freitas, Ferreira, Luiz Felipe Gomes Rebello, Hernandes, Marcelo Zaldini, de Brito, Maria Edileuza Felinto, de Oliveira, Beatriz Coutinho, da Silva, Ailton Alvaro, de-Melo-Neto, Osvaldo Pompílio, Rezende, Antônio Mauro, Pereira, Valéria Rêgo Alves“…Peptides corresponding to the top 10 ranked epitopes were synthesized and evaluated in vitro for their capacity to stimulate peripheral blood mononuclear cells (PBMC) from post-treated cutaneous leishmaniasis patients, with PBMC from healthy donors used as control. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5909por Almeida-Souza, Fernando, Cardoso, Flávia de Oliveira, Souza, Bruno Vinicius da Conceição, do Valle, Tânia Zaverucha, de Sá, Joicy Cortez, Oliveira, Iara dos Santos da Silva, de Souza, Celeste da Silva Freitas, Moragas Tellis, Carla Junqueira, Chagas, Maria do Socorro dos Santos, Behrens, Maria Dutra, Abreu-Silva, Ana Lúcia, Calabrese, Kátia da Silva“…The absence of an effective vaccine and the debilitating chemotherapy for Leishmaniasis demonstrate the need for developing alternative treatments. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5910por Aoki, Juliana Ide, Coelho, Adriano Cappellazzo, Muxel, Sandra Marcia, Zampieri, Ricardo Andrade, Sanchez, Eduardo Milton Ramos, Nerland, Audun Helge, Floeter-Winter, Lucile Maria, Cotrim, Paulo Cesar“…Although, TUB is toxic to the mammalian host, these findings can provide evidences for a rational drug design based on purine pathway against leishmaniasis. METHODOLOGY/PRINCIPAL FINDINGS: After transfection of a cosmid genomic library into L. major Friedlin (LmjF) parasites and application of the overexpression/selection method, we identified two cosmids (cosTUB1 and cosTU2) containing two different loci capable of conferring significant levels of TUB resistance. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5911por Pandey, Rajeev Kumar, Mehrotra, Sanjana, Sharma, Smriti, Gudde, Ramachandra Subbaraya, Sundar, Shyam, Shaha, Chandrima“…In a mouse model of visceral leishmaniasis (VL), Bcl-2 inhibitors partially restored the antimicrobial NO response by at least a twofold increase that resulted in significantly reduced parasite burden. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5912Pandemics, pathogenicity and changing molecular epidemiology of cholera in the era of global warmingpor Chowdhury, Fazle Rabbi, Nur, Zannatun, Hassan, Nazia, von Seidlein, Lorenz, Dunachie, Susanna“…Meta-analysis and mathematical modelling have demonstrated that due to global warming the burden of vector-borne diseases like malaria, leishmaniasis, meningococcal meningitis, viral encephalitis, dengue and chikungunya will increase in the coming years in the tropics and beyond. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5913por dos Reis, Priscila G., do Monte-Neto, Rubens L., Melo, Maria N., Frézard, Frédéric“…The growing resistance of leishmaniasis to first-line drugs like antimonials in some regions limits the control of this parasitic disease. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5914por Oliveira, Valéria da Costa, Boechat, Viviane Cardoso, Mendes Junior, Artur Augusto Velho, Madeira, Maria de Fátima, Ferreira, Luiz Claudio, Figueiredo, Fabiano Borges, Campos, Monique Paiva, de Carvalho Rodrigues, Francisco das Chagas, Carvalhaes de Oliveira, Raquel de Vasconcellos, Amendoeira, Maria Regina Reis, Menezes, Rodrigo Caldas“…Zoonotic visceral leishmaniasis is caused by the protozoan Leishmania infantum and little is known about the occurrence and pathogenesis of this parasite in the CNS. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5915por Gomes, Rodrigo Saar, Silva, Muriel Vilela Teodoro, dos Santos, Jéssica Cristina, de Lima Silva, Lucas Luiz, Batista, Aline Carvalho, Machado, Juliana Reis, Teixeira, Mauro Martins, Dorta, Miriam Leandro, de Oliveira, Milton Adriano Pelli, Dinarello, Charles A, Joosten, Leo A. B., Ribeiro-Dias, Fátima“…BACKGROUND: Interleukin 32 (IL-32) is a pro-inflammatory cytokine induced in patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5916por Mandal, Abhishek, Das, Sushmita, Kumar, Ajay, Roy, Saptarshi, Verma, Sudha, Ghosh, Ayan Kumar, Singh, Ruby, Abhishek, Kumar, Saini, Savita, Sardar, Abul Hasan, Purkait, Bidyut, Kumar, Ashish, Mandal, Chitra, Das, Pradeep“…The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, a semi-essential amino acid plays a crucial regulatory role for activation of macrophages. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5917por Maksouri, Hasnaa, Dang, Pham My-Chan, Rodrigues, Vasco, Estaquier, Jérôme, Riyad, Myriam, Akarid, Khadija“…BACKGROUND: Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by protozoa of the genus Leishmania. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5918por Abbehusen, Melissa Moura Costa, Almeida, Valter dos Anjos, Solcà, Manuela da S., Pereira, Laís da Silva, Costa, Dirceu Joaquim, Gil-Santana, Leonardo, Bozza, Patricia Torres, Fraga, Deborah Bittencourt Moté, Veras, Patrícia Sampaio Tavares, dos-Santos, Washington Luis Conrado, Andrade, Bruno Bezerril, Brodskyn, Claudia Ida“…Canine Visceral Leishmaniasis (CVL) is caused by Leishmania infantum, which in the New World is transmitted by Lutzomyia longipalpis. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5919por de Rezende, Eloiza, Kawahara, Rebeca, Peña, Mauricio S., Palmisano, Giuseppe, Stolf, Beatriz S.“…BACKGROUND: Leishmaniasis is an antropozoonosis caused by Leishmania parasites that affects around 12 million people in 98 different countries. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5920“…Our analysis was informed by a realist review (provided in the Additional file 2) focused on seven major climate-sensitive vector-borne diseases: malaria, schistosomiasis, dengue, leishmaniasis, sleeping sickness, chagas disease, and rift valley fever. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto