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5981por Chakrabarti, Amrita, Kaushik, Monika, Khan, Juveria, Soota, Deepanshu, Ponnusamy, Kalairasan, Saini, Sunil, Manvati, Siddharth, Singhal, Jhalak, Ranganathan, Anand, Pati, Soumya, Dhar, Pawan Kumar, Singh, Shailja“…The cellular assays of the tREP-18 peptide on the BS12 strain, a clinical isolate of post-kala azar dermal leishmaniasis, demonstrated its significant efficacy at an IC50 value of 15 nM. …”
Publicado 2022
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5982“…KEGG pathway enrichment analysis indicated that Staphylococcus aureus infection, osteoclast differentiation, leishmaniasis, and ECM-receptor interaction were significantly altered in septic hearts. …”
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5983por Sakyi, Patrick O., Broni, Emmanuel, Amewu, Richard K., Miller, Whelton A., Wilson, Michael D., Kwofie, Samuel Kojo“…The therapeutic challenges pertaining to leishmaniasis due to reported chemoresistance and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory molecules. …”
Publicado 2022
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5984por Mühlberg, Lars, Alarcin, Tuncay, Maass, Thorben, Creutznacher, Robert, Küchler, Richard, Mallagaray, Alvaro“…Protozoan parasites of the genus Leishmania causes Leishmaniasis, a neglected disease affecting over 12 million people worldwide. …”
Publicado 2022
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5985“…CONCLUSION: SQHJ treatment for DM targets TP53, AKT1, CASP3, and TNF and participates in pathways in leishmaniasis and cancer.…”
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5986por Moreno, Cláudia Jassica Gonçalves, Farias, Henriqueta Monalisa, de Lima Medeiros, Rafael, de Brito Pinto, Talita Katiane, de Freitas Oliveira, Johny Wysllas, de Sousa, Francimar Lopes, de Medeiros, Mayara Jane Campos, Amorim-Carmo, Bruno, Santos-Gomes, Gabriela, de Lima Pontes, Daniel, Rocha, Hugo Alexandre Oliveira, Frazão, Nilton Fereira, Silva, Marcelo Sousa“…These results together suggested L1 has a potential effect against L. amazonensis, the etiologic agent of diffuse leishmaniasis, and the only one that currently does not have a satisfactory treatment.…”
Publicado 2022
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5987por Prasad, Surendra Rajit, Kumar, Prakash, Mandal, Saptarshi, Mohan, Anu, Chaurasia, Radhika, Shrivastava, Ashish, Nikhil, Pallaprolu, Aishwarya, Dande, Ramalingam, P., Gajbhiye, Rahul, Singh, Shriya, Dasgupta, Arunava, Chourasia, Mukesh, Ravichandiran, V., Das, Prolay, Mandal, Debabrata“…We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8–C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 linear chain, but not higher, along with a carboxyl/ester group showed a similar anti-leishmanial effect. …”
Publicado 2022
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5988por Savino, Wilson, Durães, Jonathan, Maldonado-Galdeano, Carolina, Perdigon, Gabriela, Mendes-da-Cruz, Daniella Arêas, Cuervo, Patricia“…The severity of various infectious diseases including visceral leishmaniasis (VL), influenza, and tuberculosis is associated with undernutrition. …”
Publicado 2022
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5989por Rashidi, Sama, Faraji, Seyed Nooreddin, Mamaghani, Amirreza Javadi, Hatam, Saeid, Kazemi, Bahram, Bemani, Peyman, Tabaei, Seyyed Javad Seyyed, Hatam, Gholamreza“…Leishmaniasis is one of the main infectious diseases worldwide. …”
Publicado 2022
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5990por Orabi, Mohamed A. A., Alqahtani, Omaish Salman, Alyami, Bandar A., Al Awadh, Ahmed Abdullah, Abdel-Sattar, El-Shaymaa, Matsunami, Katsuyoshi, Hamdan, Dalia I., Abouelela, Mohamed E.“…Lung cancer and cutaneous leishmaniasis are critical diseases with a relatively higher incidence in developing countries. …”
Publicado 2022
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5991por Mohammed, Rezika, Melkamu, Roma, Pareyn, Myrthe, Abdellati, Said, Bogale, Tadfe, Engidaw, Asinakew, Kinfu, Abiy, Girma, Tibebu, van Griensven, Johan“…Visceral leishmaniasis (VL) is a disease caused by Leishmania parasites. …”
Publicado 2023
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5992por Sakyi, Patrick O., Kwofie, Samuel K., Tuekpe, Julius K., Gwira, Theresa M., Broni, Emmanuel, Miller, Whelton A., Wilson, Michael D., Amewu, Richard K.“…The recent outlook of leishmaniasis as a global public health concern coupled with the reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a concerted effort to find new leads. …”
Publicado 2023
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5993por Saini, Shashi, Anand, Anshul, Singh, Abhishek, Mahapatra, Baishakhi, Sirohi, Shruti, Singh, Samer, Singh, Rakesh K.“…In leishmaniasis, the protective immunity is largely mediated by proinflammatory cytokine producing abilities of T cells and an efficient parasite killing by phagocytic cells. …”
Publicado 2023
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5994por Visbal, Gonzalo, Justo, Rodrigo M. S., dos Santos da Silva e Miranda, Gabrielle, Teixeira de Macedo Silva, Sara, de Souza, Wanderley, Rodrigues, Juliany Cola Fernandes, Navarro, Maribel“…Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis of the new ZnCl(2)(H3)(2) complex. …”
Publicado 2023
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5995por Schirmann, Jéseka G., Bortoleti, Bruna T. S., Gonçalves, Manoela D., Tomiotto-Pellissier, Fernanda, Camargo, Priscila G., Miranda-Sapla, Milena M., Lima, Camilo H. S., Bispo, Marcelle L. F., Costa, Idessania N., Conchon-Costa, Ivete, Pavanelli, Wander R., Dekker, Robert F. H., Barbosa-Dekker, Aneli M.“…Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3′,5,5′-Tetramethoxy-biphenyl-4,4′-diol (TMBP) was synthesized through laccase-catalysis of 2,6-dimethoxyphenol and displayed antioxidant and anticancer activity, and is considered a potential drug candidate. …”
Publicado 2023
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5996“…The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response. …”
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5997por Silva, José Eduardo dos Santos, Jussiani, Giulia Gonçalves, Grano, Fernanda Grecco, Pelissari, Maria Cecília Clarindo, de Melo, Guilherme Dias, Negrão Watanabe, Tatiane Terumi, de Lima, Valéria Felix, Machado, Gisele Fabrino“…ABSTRACT: Visceral canine leishmaniasis (CanL) can cause several clinical manifestations, including neurological lesions. …”
Publicado 2023
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5998por Costa, Brenda Furtado, de Queiroz Filho, Tarcísio Navegante, da Cruz Carneiro, Adeniele Lopes, Falcão, Aline Semblano Carreira, da Silva Kataoka, Maria Sueli, Pinheiro, João de Jesus Viana, Rodrigues, Ana Paula Drummond“…Suggesting their potential as prognostic markers for severe leishmaniasis and promising target molecules for therapeutic interventions, this research opens new avenues for combatting this debilitating parasitic disease. …”
Publicado 2023
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5999“…The signal pathways mainly involved include Lipid and atherosclerosis, IL-17 signaling pathway, Chagas disease, leishmaniasis, and TNF signaling pathway. Moreover, molecular docking showed that the 2 most active compounds, Astragaloside IV and kaempferol, could efficiently bind with the targets TNF, TLR4, and IL10. …”
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6000por Frigerio, Edenilson Doná, Guizelini, Cecilia de Castro, Jussiani, Giulia Gonçalves, Março, Karen Santos, de Melo, Guilherme Dias, Watanabe, Tatiane Terumi Negrão, Machado, Gisele Fabrino“…BACKGROUND: Morphological involvement of endocrine glands, such as the pituitary gland, remain uninvestigated in dogs with canine visceral leishmaniasis. Therefore, this study investigated the presence of amastigotes of Leishmania spp. and characterized inflammatory changes, highlighting the involvement of TCD3(+) lymphocytes in different regions of the pituitary gland of dogs. …”
Publicado 2023
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