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6061por Buckingham-Jeffery, Elizabeth, Hill, Edward M., Datta, Samik, Dilger, Erin, Courtenay, Orin“…BACKGROUND: The parasite Leishmania infantum causes zoonotic visceral leishmaniasis (VL), a potentially fatal vector-borne disease of canids and humans. …”
Publicado 2019
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6062por Mendonça, Daiane Barros Dias, Silva, Renata Ellen Costa, Palace-Berl, Fanny, Takakura, Cleusa FH, Soares, Sandra Regina C, Braz, Lucia Maria Almeida, Tavares, Leoberto Costa, Lindoso, Jose Angelo Lauletta“…BACKGROUND: Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. …”
Publicado 2019
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6063por Afrin, Farhat, Chouhan, Garima, Islamuddin, Mohammad, Want, Muzamil Y., Ozbak, Hani A., Hemeg, Hassan A.“…BACKGROUND: There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. …”
Publicado 2019
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6064por Scariot, Débora Botura, Volpato, Hélito, Fernandes, Nilma de Souza, Soares, Edna Filipa Pais, Ueda-Nakamura, Tânia, Dias-Filho, Benedito Prado, Din, Zia Ud, Rodrigues-Filho, Edson, Rubira, Adley Forti, Borges, Olga, Sousa, Maria Do Céu, Nakamura, Celso Vataru“…Visceral leishmaniasis, caused by Leishmania infantum, is a neglected tropical disease, to which efforts in the innovation of effective and affordable treatments remain limited, despite the rising incidence in several regions of the world. …”
Publicado 2019
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6065por Leony, Leonardo M., Freitas, Natália E. M., Del-Rei, Rodrigo P., Carneiro, Claudia M., Reis, Alexandre B., Jansen, Ana Maria, Xavier, Samanta C. C., Gomes, Yara M., Silva, Edmilson D., Reis, Mitermayer G., Fraga, Deborah B. M., Celedon, Paola A. F., Zanchin, Nilson I. T., Dantas-Torres, Filipe, Santos, Fred L. N.“…Cross-reactivity was also evaluated for babesiosis, ehrlichiosis, dirofilariosis, anaplasmosis, and visceral leishmaniasis. Best performance was shown by IBMP-8.3 and IBMP-8.4, although all four antigens demonstrated a high diagnostic performance with 46 positive and 149 negative samples tested. …”
Publicado 2019
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6066por Gannavaram, Sreenivas, Bhattacharya, Parna, Siddiqui, Abid, Ismail, Nevien, Madhavan, Subha, Nakhasi, Hira L.“…No vaccine exists against visceral leishmaniasis. Toward developing vaccines against VL, we have reported previously on the immunogenicity of live attenuated LdCen(−/−) parasites in animal models. …”
Publicado 2019
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6067“…BACKGROUND: Miltefosine is an alkylphosphocholine compound used primarily for the treatment of leishmaniasis that also demonstrates in vitro and in vivo anti-amebic activity against Acanthamoeba species. …”
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6068por dos Santos, Íria Gabriela Dias, de Oliveira Mendes, Tiago Antônio, Silva, Gerluza Aparecida Borges, Reis, Amanda Maria Sena, Monteiro-Vitorello, Cláudia Barros, Schaker, Patricia Dayane Carvalho, Herai, Roberto Hirochi, Fabotti, André Brait Carneiro, Coutinho, Luiz Lehmann, Jorge, Erika Cristina“…It has been used as an animal model for studying different scientific questions ranging from the restoration of degraded green areas to medical aspects of Chagas disease, leishmaniasis and resistance against snake venom. As a marsupial, D. albiventris can also contribute to the understanding of the molecular mechanisms that govern the different stages of organogenesis. …”
Publicado 2019
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6069por Azevedo, Lucas Gentil, de Queiroz, Artur Trancoso Lopo, Barral, Aldina, Santos, Luciane Amorim, Ramos, Pablo Ivan Pereira“…BACKGROUND: Leishmania spp. are digenetic parasites capable of infecting humans and causing a range of diseases collectively known as leishmaniasis. The main mechanisms involved in the development and permanence of this pathology are linked to evasion of the immune response. …”
Publicado 2020
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6070por Gatto, Mariana, Borim, Patrícia Aparecida, Wolf, Ivan Rodrigo, Fukuta da Cruz, Taís, Ferreira Mota, Gustavo Augusto, Marques Braz, Aline Márcia, Casella Amorim, Bárbara, Targino Valente, Guilherme, de Assis Golim, Marjorie, Venturini, James, Araújo Junior, João Pessoa, Pontillo, Alessandra, Sartori, Alexandrina“…Leishmaniasis is caused by intracellular parasites transmitted to vertebrates by sandfly bites. …”
Publicado 2020
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6071por Kumar, Vinod, Das, Sushmita, Kumar, Ajay, Tiwari, Neeraj, Kumar, Ashish, Abhishek, Kumar, Mandal, Abhishek, Kumar, Manjay, Shafi, Taj, Bamra, Tanvir, Singh, Rakesh Kumar, Vijayakumar, Saravanan, Sen, Abhik, Das, Pradeep“…Visceral leishmaniasis is characterized by mixed production of Th1/2 cytokines and the disease is established by an enhanced level of Th2 cytokine. …”
Publicado 2020
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6072por Vitoriano-Souza, Juliana, Moreira, Nádia das Dores, Menezes-Souza, Daniel, Roatt, Bruno Mendes, de Oliveira Aguiar-Soares, Rodrigo Dian, Siqueira-Mathias, Fernando Augusto, de Oliveira Cardoso, Jamille Mirelle, Giunchetti, Rodolfo Cordeiro, de Sá, Renata Guerra, Corrêa-Oliveira, Rodrigo, Carneiro, Cláudia Martins, Reis, Alexandre Barbosa“…Information about the kinetics of the immune response to this vaccine gained using this dog model will help to elucidate the mechanisms of and factors involved in a protective response against Leishmania infection and will aid in establishing rational approaches for the development of vaccines against canine visceral leishmaniasis.…”
Publicado 2013
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6073por Rehder, Dieter“…In addition, in vitro studies with cell cultures and parasites, as well as in vivo studies with animals, have revealed a broad potential spectrum for the application of vanadium coordination compounds in the treatment of cardiac and neuronal disorders, malignant tumors, viral and bacterial infections (such as influenza, HIV, and tuberculosis), and tropical diseases caused by parasites, e.g., Chagas’ disease, leishmaniasis, and amoebiasis.…”
Publicado 2013
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6074“…BACKGROUND: Leishmaniasis is a human and animal disease caused by parasites of the genus Leishmania, which is now divided into four subgenera, Leishmania, Viannia, Sauroleishmania and Mundinia. …”
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6075por Khan, Md Anik Ashfaq, Ami, Jenifar Quaiyum, Faisal, Khaledul, Chowdhury, Rajashree, Ghosh, Prakash, Hossain, Faria, Abd El Wahed, Ahmed, Mondal, Dinesh“…BACKGROUND: Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a parasitic disease with high socioeconomic burden in endemic areas worldwide. …”
Publicado 2020
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6076por Boton Pereira, Denise Helena, Primo, Lívia Souza, Pelizari, Giovana, Flores, Edilson, de Moraes-Vasconcelos, Dewton, Condino-Neto, Antonio, Prestes-Carneiro, Luiz Euribel“…Autoimmune diseases were diagnosed in 56.4% and visceral leishmaniasis in 5.1% of patients. In the active search, 29 patients were investigated and 17.2% were diagnosed; early diagnosis, the involvement of multidisciplinary professionals, and dissemination of knowledge achieved milestone benefits. …”
Publicado 2020
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6077por Crentsil, Justice Afrifa, Yamthe, Lauve Rachel Tchokouaha, Anibea, Barbara Zenabu, Broni, Emmanuel, Kwofie, Samuel Kojo, Tetteh, John Kweku Amissah, Osei-Safo, Dorcas“…Leishmania is a parasitic protozoon responsible for the neglected tropical disease Leishmaniasis. Approximately, 350 million people are susceptible and close to 70,000 death cases globally are reported annually. …”
Publicado 2020
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6078por Mahmoud, Abdelhalim Babiker, Mäser, Pascal, Kaiser, Marcel, Hamburger, Matthias, Khalid, Sami“…Annually, up to 30 million people are affected by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria. …”
Publicado 2020
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6079por Upegui Zapata, Yulieth A., Echeverri, Fernando, Quiñones, Winston, Torres, Fernando, Nacher, Montserrat, Rivas, Luis I., Meira, Camila dos Santos, Gedamu, Lashitew, Escobar, Gustavo, Archbold, Rosendo, Vélez, Iván D., Robledo, Sara M.“…Mixtures of TC1 or TC2 with saponin were formulated for topical application and the therapeutic effectiveness was evaluated in the model for cutaneous leishmaniasis (CL) in golden hamster. The mode of action of these compounds was tested on various parasite processes and ultrastructural parasite modifications. …”
Publicado 2020
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6080por Gedda, Mallikarjuna Rao, Madhukar, Prasoon, Vishwakarma, Alok Kumar, Verma, Vimal, Kushwaha, Anurag Kumar, Yadagiri, Ganesh, Mudavath, Shyam Lal, Singh, Om Prakash, Srivastava, Onkar Nath, Sundar, Shyam“…Visceral leishmaniasis (VL) has been a major health concern in the developing world, primarily affecting impoverished people. …”
Publicado 2020
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