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6121por Chouhan, Garima, Islamuddin, Mohammad, Want, Muzamil Y, Abdin, Malik Z, Ozbak, Hani A, Hemeg, Hassan A, Sahal, Dinkar, Afrin, Farhat“…BACKGROUND: Exploration of immunomodulatory antileishmanials of plant origin is now being strongly recommended to overcome the immune suppression evident during visceral leishmaniasis (VL) and high cost and toxicity associated with conventional chemotherapeutics. …”
Publicado 2015
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6122por Seblova, Veronika, Myskova, Jitka, Hlavacova, Jana, Votypka, Jan, Antoniou, Maria, Volf, Petr“…In Cukurova region in Turkey we previously identified a major focus of cutaneous leishmaniasis caused by L. donovani/infantum hybrids (CUK strain) and isolated this parasite from the locally abundant sand fly, Phlebotomus tobbi. …”
Publicado 2015
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6123por Andrade-Neto, Valter Viana, Pereira, Thaís Martins, Canto-Cavalheiro, Marilene do, Torres-Santos, Eduardo Caio“…Using imipramine in combination with azoles may be advantageous for the treatment of leishmaniasis.…”
Publicado 2016
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6124por Vivero, Rafael José, Jaramillo, Natalia Gil, Cadavid-Restrepo, Gloria, Soto, Sandra I. Uribe, Herrera, Claudia Ximena Moreno“…BACKGROUND: Lutzomyia evansi, a phlebotomine insect endemic to Colombia’s Caribbean coast, is considered to be the main vector of visceral and cutaneous leishmaniasis in the region. Although insects of this species can harbor pathogenic and non-pathogenic microorganisms in their intestinal microbiota, there is little information available about the diversity of gut bacteria present in Lutzomyia evansi. …”
Publicado 2016
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6125por Agallou, Maria, Margaroni, Maritsa, Athanasiou, Evita, Toubanaki, Dimitra K., Kontonikola, Katerina, Karidi, Konstantina, Kammona, Olga, Kiparissides, Costas, Karagouni, Evdokia“…CONCLUSIONS/SIGNIFICANCE: This study provide a basis for the development of peptide-based nanovaccines against leishmaniasis, since it reveals that vaccination with well-defined Leishmania MHC-restricted epitopes extracted from various immunogenic proteins co-encapsulated with the proper adjuvant or/and phlebotomine fly saliva multi-epitope peptides into clinically compatible PLGA NPs could be a promising approach for the induction of a strong and sustainable protective immunity.…”
Publicado 2017
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6126“…BACKGROUND: Before 1996 the phlebotomine sand fly Lutzomyia neivai was usually treated as a synonym of the morphologically similar Lutzomyia intermedia, which has long been considered a vector of Leishmania braziliensis, the causative agent of much cutaneous leishmaniasis in South America. This report investigates the likely range changes of both sand fly species in response to a stabilisation climate change scenario (RCP4.5) and a high greenhouse gas emissions one (RCP8.5). …”
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6127por Aklilu, Esayas, Gebresilassie, Araya, Yared, Solomon, Kindu, Mizan, Tekie, Habte, Balkew, Meshesha, Warburg, Alon, Hailu, Asrat, Gebre-Michael, Teshome“…BACKGROUND: Visceral leishmaniasis (VL) also known as kala-azar is a growing health problem in Ethiopia with an estimated annual VL incidence between 3700 and 7400. …”
Publicado 2017
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6128por Douine, Maylis, Mosnier, Emilie, Le Hingrat, Quentin, Charpentier, Charlotte, Corlin, Florine, Hureau, Louise, Adenis, Antoine, Lazrek, Yassamine, Niemetsky, Florence, Aucouturier, Anne-Laure, Demar, Magalie, Musset, Lise, Nacher, Mathieu“…They declared frequent arboviroses and digestive disorders. Active leishmaniasis was observed in 8.3% of gold miners. Among women, 28.5% were anemic. …”
Publicado 2017
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6129por Eder, Marcus, Cortes, Fanny, Teixeira de Siqueira Filha, Noêmia, Araújo de França, Giovanny Vinícius, Degroote, Stéphanie, Braga, Cynthia, Ridde, Valéry, Turchi Martelli, Celina Maria“…Other arboviruses covered included chikungunya and West Nile virus, other parasitic diseases such as leishmaniasis and trypanosomiasis, and bacterial rickettsiosis and plague. …”
Publicado 2018
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6130por Rodrigues, Carina Agostinho, dos Santos, Paloma Freire, da Costa, Marcela Oliveira Legramanti, Pavani, Thais Fernanda Amorim, Xander, Patrícia, Geraldo, Mariana Marques, Mengarda, Ana, de Moraes, Josué, Rando, Daniela Gonçales Galasse“…That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. …”
Publicado 2018
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6131por Gomez, Sonia Ares, Lucientes, Javier, Castillo, Juan Antonio, Peris, Maria Paz, Delacour, Sarah, Ortega, Paula, Oropeza, Ronald-Vladimir, Picado, Albert“…BACKGROUND: Leishmania infantum is the parasite responsible for the disease in humans known as zoonotic visceral leishmaniasis (ZVL). Dogs are considered the main domestic reservoir of ZVL and sand flies are the proven vectors. …”
Publicado 2018
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6132por Cardenas, Daviel, Sylvester, Charity, Cao, Bo, Nation, Catherine S., Pizarro, Juan C., Lu, Hua, Guidry, Jessie, Wojcik, Edward J., Kelly, Ben L.“…IMPORTANCE Leishmania parasites are trypanosomatid protozoans that persist in infected human hosts to cause a spectrum of pathologies, from cutaneous and mucocutaneous manifestations to visceral leishmaniasis caused by Leishmania donovani. The latter is usually fatal if not treated. …”
Publicado 2019
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6133por Borbón, Tiffany Y., Scorza, Breanna M., Clay, Gwendolyn M., Lima Nobre de Queiroz, Fellipe, Sariol, Alan J., Bowen, Jayden L., Chen, Yani, Zhanbolat, Bayan, Parlet, Corey P., Valadares, Diogo G., Cassel, Suzanne L., Nauseef, William M., Horswill, Alexander R., Sutterwala, Fayyaz S., Wilson, Mary E.“…Cutaneous leishmaniasis (CL) is a parasitic disease causing chronic, ulcerating skin lesions. …”
Publicado 2019
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6134por Chaves, Mariana M., Sinflorio, Debora A., Thorstenberg, Maria Luiza, Martins, Monique Daiane Andrade, Moreira-Souza, Aline Cristina Abreu, Rangel, Thuany Prado, Silva, Claudia L. M., Bellio, Maria, Canetti, Claudio, Coutinho-Silva, Robson“…Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. …”
Publicado 2019
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6135por Erisoz Kasap, Ozge, Linton, Yvonne-Marie, Karakus, Mehmet, Ozbel, Yusuf, Alten, Bulent“…BACKGROUND: Currently, knowledge regarding the phlebotomine sand fly (Diptera: Psychodidae) fauna of Turkey is restricted to regions with endemic leishmaniasis. However, rapidly changing environmental and social conditions highlight concerns on the possible future expansion of sand fly-borne diseases in Turkey, promoting risk assessment through biosurveillance activities in non-endemic regions. …”
Publicado 2019
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6136por Guegan, Hélène, Ory, Kevin, Belaz, Sorya, Jan, Aurélien, Dion, Sarah, Legentil, Laurent, Manuel, Christelle, Lemiègre, Loïc, Vives, Thomas, Ferrières, Vincent, Gangneux, Jean-Pierre, Robert-Gangneux, Florence“…BACKGROUND: The chemotherapeutic arsenal available to treat visceral leishmaniasis is currently limited, in view of many drawbacks such as high cost, toxicity or emerging resistance. …”
Publicado 2019
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6137por Viana, Kelvinson Fernandes, Aguiar-Soares, Rodrigo Dian Oliveira, Roatt, Bruno Mendes, Resende, Lucilene Aparecida, Silveira-Lemos, Denise da, Corrêa-Oliveira, Rodrigo, Martins-Filho, Olindo Assis, Moura, Sandra Lima, Zanini, Marcos Santos, Araújo, Márcio Sobreira Silva, Reis, Alexandre Barbosa, Giunchetti, Rodolfo Cordeiro“…Canine visceral leishmaniasis (CVL) is a parasitic disease endemic in many countries, and dogs present as the major natural reservoir of the parasite, Leishmania chagasi (syn. …”
Publicado 2013
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6138por Viana, Kelvinson Fernandes, Aguiar-Soares, Rodrigo Dian Oliveira, Ker, Henrique Gama, Resende, Lucilene Aparecida, Souza-Fagundes, Elaine Maria, Dutra, Walderez Ornelas, Fujiwara, Ricardo Toshio, Silveira-Lemos, Denise da, Sant'Ana, Rita de Cássia Oliveira, Wardini, Amanda Brito, Araújo, Márcio Sobreira Silva, Martins-Filho, Olindo Assis, Reis, Alexandre Barbosa, Giunchetti, Rodolfo Cordeiro“…The present study intended to establish an in vitro toll to assess the parasitological/immunological status of dogs, applicable in pre-clinical trials of vaccinology, prognosis follow-up and therapeutics analysis of canine visceral leishmaniasis. We have evaluated the performance of co-culture systems of canine Leishmania chagasi–infected macrophages with different cell ratios of total lymphocytes or purified CD4(+) and CD8(+) T-cells. …”
Publicado 2015
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6139por Martínez-Flórez, Alba, Martori, Clara, Monteagudo, Paula L., Rodriguez, Fernando, Alberola, Jordi, Rodríguez-Cortés, Alhelí“…In the search for a safe and efficient protective vaccine for human and dog visceral leishmaniases, we analyzed the suitability of the immunomodulatory drug sirolimus (SIR) to boost a preventive DNA vaccine against leishmaniasis. SIR is an already marketed drug that has been described to boost immune protection against different disease models and has also emerged as a promising therapeutic drug against L. major. …”
Publicado 2020
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6140por Nadaes, Natalia Rocha, Silva da Costa, Leandro, Santana, Raissa Couto, LaRocque-de-Freitas, Isabel Ferreira, Vivarini, Áislan de Carvalho, Soares, Deivid Costa, Wardini, Amanda Brito, Gazos Lopes, Ulisses, Saraiva, Elvira M., Freire-de-Lima, Celio Geraldo, Decote-Ricardo, Debora, Pinto-da-Silva, Lucia Helena“…Leishmaniasis is an anthropozoonotic disease, and dogs are considered the main urban reservoir of the parasite. …”
Publicado 2020
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