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22por Bailey, Mai Ann, Na, Hana, Duthie, Malcolm S., Gillis, Thomas P., Lahiri, Ramanuj, Parish, Tanya“…Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. …”
Publicado 2017
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23por de Lima, Maxwell Furtado, Silvestre, Maria do Perpétuo Socorro Amador, dos Santos, Everaldina Cordeiro, Martins, Lívia Caricio, Quaresma, Juarez Antônio Simões, de Barros, Bruno de Cássio Veloso, Silva, Marcos Jessé Abrahão, Lima, Luana Nepomuceno Gondim Costa“…This unprecedented finding suggests that species other than those previously reported are responsible for maintaining M. leprae in nature.…”
Publicado 2022
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24por Couret, Maurice“…The resistance of some animals to Bacillus lepræ is well illustrated by two cats which were inoculated subcutaneously and intraperitoneally with a heavy suspension of Bacillus lepræ. …”
Publicado 1911
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25“…The waxes from the B. leprae, like those from tubercle bacilli, are remarkable stimulants of cells. 2. …”
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28por Thangaraju, Pugazhenthan, Venkatesan, Sajitha, Sivashanmugam, Elavarasan, Showkath Ali, M KEnlace del recurso
Publicado 2017
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29por Blevins, Kelly E., Crane, Adele E., Lum, Christopher, Furuta, Kanako, Fox, Keolu, Stone, Anne C.“…Most human leprosy cases are caused by Mycobacterium leprae, but a small number of cases are now known to be caused by Mycobacterium lepromatosis, a sister taxon of M. leprae. …”
Publicado 2020
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30“…Studying Mycobacterium leprae, the causative agent of leprosy, at the proteomic level may facilitate the identification, quantification, and characterization of proteins that could be potential diagnostics or targets for drugs and can help in better understanding the pathogenesis. …”
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32por Millogo, Anselme, Loukil, Ahmed, L’Ollivier, Coralie, Djibougou, Diakourga Arthur, Godreuil, Sylvain, Drancourt, Michel“…This observation raises questions about the role of fecal excretion of M. leprae in the natural history and diagnosis of leprosy.…”
Publicado 2021
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34por Cabral, Natasha, de Figueiredo, Vilma, Gandini, Mariana, de Souza, Cíntia Fernandes, Medeiros, Rychelle Affonso, Lery, Letícia Miranda Santos, Lara, Flávio Alves, de Macedo, Cristiana Santos, Pessolani, Maria Cristina Vidal, Pereira, Geraldo Moura Batista“…The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. …”
Publicado 2022
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35Materias: “…Quimioterapia Lepra…”
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36por Truman, Richard W., Andrews, P. Kyle, Robbins, Naoko Y., Adams, Linda B., Krahenbuhl, James L., Gillis, Thomas P.“…The assay was specific for M. leprae and able to detect 10 fg of purified M. leprae DNA, or approximately 300 bacteria in infected tissues. …”
Publicado 2008
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37por Williams, Diana L, Slayden, Richard A, Amin, Amol, Martinez, Alejandra N, Pittman, Tana L, Mira, Alex, Mitra, Anirban, Nagaraja, Valakunja, Morrison, Norman E, Moraes, Milton, Gillis, Thomas P“…BACKGROUND: The Mycobacterium leprae genome has less than 50% coding capacity and 1,133 pseudogenes. …”
Publicado 2009
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38por Alban, Silvana M, de Moura, Juliana Ferreira, Minozzo, João Carlos, Mira, Marcelo Távora, Soccol, Vanete Thomaz“…The intradermal challenge with peptides in animals previously sensitized with Mycobacterium leprae induced a delayed-type hypersensitivity with peptide 5A (2/5) and peptide 1B (1/5). …”
Publicado 2013
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39“…BACKGROUND: Leprosy is a contagious and chronic systemic granulomatous disease caused by Mycobacterium leprae. In the pathogenesis of leprosy, granulomas play a key role, however, the mechanisms of the formation and maintenance of M. leprae granulomas are still not clearly understood. …”
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40por Veziris, Nicolas, Chauffour, Aurélie, Escolano, Sylvie, Henquet, Sarah, Matsuoka, Masanori, Jarlier, Vincent, Aubry, Alexandra“…CONCLUSION/SIGNIFICANCE: DNA gyrase mutation is not always synonymous of lack of in vivo fluoroquinolone activity in M. leprae. As for M. tuberculosis, in vivo studies allow to measure residual antibiotic activity in case of target mutations in M. leprae.…”
Publicado 2013
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