“…For example, cytochrome c, which is normally confined to the mitochondrial intermembrane space, is liberated from mitochondria and interacts with a cytosolic protein, Apaf-1, causing its oligomerization and constitution of the so-called apoptosome, a protein complex which activates a specific class of cysteine proteases, the caspases[2]. …”
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“…Aqueous NaOH dramatically promotes solution phase HMF activation, liberating free gold sites able to activate the alcohol function within the metastable 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) reactive intermediate. …”
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“…It shows that indeed a multidimensional approach to economic issues is justified; that voters who oppose reforms are characterized by higher levels of Euroscepticism; and that this reform dimension helps to understand voting behaviour, in particular preferences for the socialist, social-democratic and social-liberal party.…”
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“…Furthermore, exogenous neutrophil elastase liberated by degranulating neutrophils was demonstrated to alter trophoblast physiology and glucose metabolism by interfering with key signal transduction components. …”
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“…Addition of biotin competitively disrupts this interaction, liberating the biosensor from its hook. We constructed a human cell line co-expressing soluble secretory-SBP-GFP (ss-SBP-GFP) and streptavidin within the endoplasmic reticulum (ER) lumen and then used this system to screen a compound library for inhibitors of the biotin-induced release of ss-SBP-GFP via the conventional Golgi-dependent protein secretion pathway into the culture supernatant. …”
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“…A circumferential incision is made around the fistula in the vestibule; fistula tract is dissected liberally and delivered by invagination into the bowel. …”
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“…In addition, SEV binding affinity to SBEβCD was confirmed by a minimal Gibbs free energy of binding (ΔG(bind)) value of −1.727 ± 0.042 kcal·mol(−1) and an average binding constant (K(b)) of 53.66 ± 9.24 mM indicating rapid drug liberation from the cyclodextrin amphiphilic cavity.…”
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“…The reaction of the previously known bis(6-diphenylphosphinoacenaphthyl-5-)telluride (6-Ph(2)P-Ace-5-)(2)Te (IV) with (CO)(5)ReCl and (CO)(5)MnBr proceeded with the liberation of CO and provided fac-(6-Ph(2)P-Ace-5-)(2)TeM(X)(CO)(3) (fac-1: M = Re, X = Cl; fac-2: M = Mn, X = Br), in which IV acts as bidentate ligand. …”
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“…After the consumption of 575.0 µg α-thujone, the 4-hydroxythujone and 7-hydroxythujone were detectable in the urine of the volunteers under study, after liberation from their glucuronides/sulfates. The 2-Hydroxythujone was not present in any of the volunteer samples above its detection limit. α-Thujone was detectable in a low amount, with a maximum concentration of 94 ng/L for the volunteer with the highest dose of 14.3 µg/kg bw.…”
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“…Finally, we report a preliminary step towards developing a catalytic methodology; the allene may be liberated from the metal center by exposure of the complex to an atmosphere of carbon monoxide.…”
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“…Their ability to moderately inhibit R2 RNR protein in the presence of dithiothreitol is likely related to Fe chelating properties of the proligands liberated upon reduction.…”
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“…The colorimetric method is based on the reaction of arsenic (III) with potassium iodate in acid medium to liberate iodine, which oxidizes leucomalachite green to malachite green. …”
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“…Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane. …”
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“…Current political developments in established liberal democracies in both Europe and North America have fundamentally called into question the normative relations between truth, knowledge and politics. …”
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“…However, bioinformatics education is not well integrated at the undergraduate level, especially in liberal arts colleges and regional universities in the United States. …”
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“…Indeed, teaching is not only a required component of any faculty position, it is the primary task for trainees who seek employment at small liberal arts colleges and other primarily undergraduate institutions. …”
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“…He developed acute respiratory failure leading to intubation, but was thereafter liberated from the ventilator following clinical stabilization. …”
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“…Many cell surface receptors internalize their ligands and deliver them to endosomes, where the acidic pH causes the ligand to dissociate. The liberated receptor returns to the cell surface in a process called receptor cycling. …”
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“…The obtained P,N-doped cellulose fibrils with high liberation were thereafter incorporated into a high-density polyethylene (HDPE) matrix to improve the flame retardancy of HDPE composites, and they had a significant improvement on flame retardancy of HDPE composites. …”
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“…Prevention of VAP is based on minimizing the exposure to mechanical ventilation and encouraging early liberation. Bundles that combine multiple prevention strategies may improve outcomes, but large randomized trials are needed to confirm this. …”
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