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3841por Hur, Ji-Yeun“…Since γ-secretase mediates the final cleavage that liberates Aβ, γ-secretase has been widely studied as a potential drug target for the treatment of AD. γ-Secretase is a transmembrane protein complex containing presenilin, nicastrin, Aph-1, and Pen-2, which are sufficient for γ-secretase activity. γ-Secretase cleaves >140 substrates, including APP and Notch. …”
Publicado 2022
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3842“…Therefore, many fluorophore fragments are liberated to produce a significantly amplified fluorescence signal toward CEA detection. …”
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3843por Gao, Fenglei, Wu, Jing, Yao, Yao, Zhang, Yu, Liao, Xianjiu, Geng, Deqin, Tang, Daoquan“…Subsequent catalytic cleavage of the DNAzyme by the corresponding metal ions results in recycling of the enzymatic sequences and cyclic cleavage of the substrate strand, liberating many short FAM-linked oligonuleotide fragments separated from the GO surface, which results in fluorescence enhancement due to the weak affinity of the short FAM-linked oligonuleotide fragment to GO. …”
Publicado 2018
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3844“…The results indicated that credibility consistently mediated the effects of the moral violation frame on climate engagement and that liberal-leaning individuals were more likely to perceive an individualizing frame as more credible than a binding frame. …”
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3845por Ihara, Yuta, Wakamatsu, Takayuki, Yokoyama, Mineyuki, Maezawa, Daisuke, Ohta, Hiroyuki, Shimojima, Mie“…Therefore, KODA production in transgenic plants stably expressing 9-LOX and AOS requires specific sub-cellular localization of these two enzymes and incubation of crude leaf extracts, which liberates α-linolenic acid via breakdown of endogenous lipids.…”
Publicado 2021
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3846por Hu, Qiwei, Yammani, Rama D., Brown-Harding, Heather, Soto-Pantoja, David R., Poole, Leslie B., Lukesh, John C.“…Herein, we describe a novel, H(2)O(2)-responsive DOX hybrid codrug (mutual prodrug) that has been rationally designed to concurrently liberate hydrogen sulfide (H(2)S), a purported cardioprotectant with anticancer activity, in an effort to maintain the antitumor effects of DOX while simultaneously reducing its cardiotoxic side effects. …”
Publicado 2022
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3847“…We observed substantial increases in the hazard and incidence of red wolf reported poaching, and smaller increases in disappearances, during periods of reduced federal and state protections (including liberalizing hunting of coyotes, C. latrans); white-tailed deer (Odocoileus virginianus) and American black bear (Ursus americanus) hunting seasons; and management phases. …”
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3848“…We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron.…”
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3849por Belete, Sonja, Duke, Chris, Hinzen, Heribert, Owusu-Boampong, Angela, Khau, Huu Phuoc“…These are spaces offering opportunities for literacy and skills training, health and citizenship, general, liberal and vocational education, in line with fuller recognition of the meaning of lifelong learning, and in the context of local communities. …”
Publicado 2022
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3850“…For instrumental variables, 37 single nucleotide polymorphisms that had been previously identified to be related to CRP levels were used, including 4 SNPs of conservative CRP genetic variants and 33 SNPs of liberal CRP genetic variants. MR estimates were calculated using the inverse-variance weighted method, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. …”
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3851por Chaplin, Joshua D., Christl, Marcus, Straub, Marietta, Bochud, François, Froidevaux, Pascal“…If fuel rods leak, they liberate radionuclides into the cooling water; therefore, it is essential to determine radionuclide concentrations in the pool water for monitoring purposes and to plan the decommissioning process. …”
Publicado 2022
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3852por Huang, Yi-Xiong, Xu, Zheng-Ming, Zhao, Li, Cao, Yi, Chen, Yu, Qiu, Yi-Gang, Liu, Ying-Ming, Zhang, Peng-Yu, He, Jiang-Chun, Li, Tian-Chang“…METHODS: In the present observational cohort study, 61 patients who received VA-ECMO-supported high-risk PCI between April 2012 and January 2020 at the Sixth Medical Center of Chinese People’s Liberation Army General Hospital were enrolled. The endpoint characteristics such as all-cause mortality, repeated cardiovascular diseases, and cardiac death were examined. …”
Publicado 2022
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3853“…Meanwhile, the dihydrogen bond (N–H(δ+)···(δ−)H–B) is favorably formed under E(ext), and the interaction between relevant H atoms is enhanced, leading to a faster H(2) liberation. Correspondingly, the apparent activation energy for AB dissociation is greatly reduced from 18.42 to around 15 kcal·mol(–1) with the application of an electric field, while that for H(2) formation decreases from 20.4 to about 16 kcal·mol(–1). …”
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3854por Symons, Xavier“…Conscience is an idea that has significant currency in liberal democratic societies. Yet contemporary moral philosophical scholarship on conscience is surprisingly sparse. …”
Publicado 2022
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3855por Fadimu, Gbemisola J., Le, Thao T., Gill, Harsharn, Farahnaky, Asgar, Olatunde, Oladipupo Odunayo, Truong, Tuyen“…In the food industry, enzymatic hydrolysis is the most common technique employed for the liberation of BPs from proteins in which conventional heat treatment is used as pre-treatment to enhance hydrolytic action. …”
Publicado 2022
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3856por Fukushima, Kyosuke, Kabir, Mahmudul, Kanda, Kensuke, Obara, Naoko, Fukuyama, Mayuko, Otsuki, Akira“…The HV electric-pulse application shows a good possibility of achieving a high energy efficiency with the size reduction and selective liberation of minerals from rocks. The electric and dielectric properties were first measured, and the mineral compositions were also determined by using a micro-X-ray fluorescence spectrometer. …”
Publicado 2022
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3857“…Due to their time‐consuming nature, enzymatic methods for liberation of single muscle fibers with fully quiescent MuSCs are challenging. …”
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3858por So, Derek“…In comparison with earlier images of germline modification, they also suggest a more contemporary, Western, and politically liberal social context for gene editing technology. …”
Publicado 2021
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3859“…We argue this may be linked to its higher level of inequality typical of liberal labour markets.…”
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3860“…Cleaning products contain numerous individual chemicals, which can be liberated on use. These species can react in air to form new chemical species, some of which are harmful to health. …”
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