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  1. 3841
    por Hur, Ji-Yeun
    Publicado 2022
    “…Since γ-secretase mediates the final cleavage that liberates Aβ, γ-secretase has been widely studied as a potential drug target for the treatment of AD. γ-Secretase is a transmembrane protein complex containing presenilin, nicastrin, Aph-1, and Pen-2, which are sufficient for γ-secretase activity. γ-Secretase cleaves >140 substrates, including APP and Notch. …”
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    γ-Secretase in Alzheimer’s disease
  2. 3842
    “…Therefore, many fluorophore fragments are liberated to produce a significantly amplified fluorescence signal toward CEA detection. …”
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    Single-step and ultrasensitive detection of carcinoembryonic antigen based on an aptamer transduction-mediated exonuclease III-assisted dual-amplification strategy
  3. 3843
    “…Subsequent catalytic cleavage of the DNAzyme by the corresponding metal ions results in recycling of the enzymatic sequences and cyclic cleavage of the substrate strand, liberating many short FAM-linked oligonuleotide fragments separated from the GO surface, which results in fluorescence enhancement due to the weak affinity of the short FAM-linked oligonuleotide fragment to GO. …”
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    Proximity hybridization triggered strand displacement and DNAzyme assisted strand recycling for ATP fluorescence detection in vitro and imaging in living cells
  4. 3844
    “…The results indicated that credibility consistently mediated the effects of the moral violation frame on climate engagement and that liberal-leaning individuals were more likely to perceive an individualizing frame as more credible than a binding frame. …”
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    Framing Climate Change Impacts as Moral Violations: The Pathway of Perceived Message Credibility
  5. 3845
    “…Therefore, KODA production in transgenic plants stably expressing 9-LOX and AOS requires specific sub-cellular localization of these two enzymes and incubation of crude leaf extracts, which liberates α-linolenic acid via breakdown of endogenous lipids.…”
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    Developing a platform for production of the oxylipin KODA in plants
  6. 3846
    “…Herein, we describe a novel, H(2)O(2)-responsive DOX hybrid codrug (mutual prodrug) that has been rationally designed to concurrently liberate hydrogen sulfide (H(2)S), a purported cardioprotectant with anticancer activity, in an effort to maintain the antitumor effects of DOX while simultaneously reducing its cardiotoxic side effects. …”
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    Mitigation of doxorubicin-induced cardiotoxicity with an H(2)O(2)-Activated, H(2)S-Donating hybrid prodrug
  7. 3847
    “…We observed substantial increases in the hazard and incidence of red wolf reported poaching, and smaller increases in disappearances, during periods of reduced federal and state protections (including liberalizing hunting of coyotes, C. latrans); white-tailed deer (Odocoileus virginianus) and American black bear (Ursus americanus) hunting seasons; and management phases. …”
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    Evaluating how management policies affect red wolf mortality and disappearance
  8. 3848
    “…We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron.…”
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    Activation of Nrf2/HO-1 Antioxidant Pathway by Heme Attenuates Calcification of Human Lens Epithelial Cells
  9. 3849
    “…These are spaces offering opportunities for literacy and skills training, health and citizenship, general, liberal and vocational education, in line with fuller recognition of the meaning of lifelong learning, and in the context of local communities. …”
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    Community Learning Centres (CLCs) for Adult Learning and Education (ALE): development in and by communities
  10. 3850
    “…For instrumental variables, 37 single nucleotide polymorphisms that had been previously identified to be related to CRP levels were used, including 4 SNPs of conservative CRP genetic variants and 33 SNPs of liberal CRP genetic variants. MR estimates were calculated using the inverse-variance weighted method, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. …”
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    Association Between C-Reactive Protein and Risk of Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study
  11. 3851
    “…If fuel rods leak, they liberate radionuclides into the cooling water; therefore, it is essential to determine radionuclide concentrations in the pool water for monitoring purposes and to plan the decommissioning process. …”
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    Passive Sampling Tool for Actinides in Spent Nuclear Fuel Pools
  12. 3852
    “…METHODS: In the present observational cohort study, 61 patients who received VA-ECMO-supported high-risk PCI between April 2012 and January 2020 at the Sixth Medical Center of Chinese People’s Liberation Army General Hospital were enrolled. The endpoint characteristics such as all-cause mortality, repeated cardiovascular diseases, and cardiac death were examined. …”
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    Long-term outcomes of high-risk percutaneous coronary interventions under extracorporeal membrane oxygenation support: An observational study
  13. 3853
    “…Meanwhile, the dihydrogen bond (N–H(δ+)···(δ−)H–B) is favorably formed under E(ext), and the interaction between relevant H atoms is enhanced, leading to a faster H(2) liberation. Correspondingly, the apparent activation energy for AB dissociation is greatly reduced from 18.42 to around 15 kcal·mol(–1) with the application of an electric field, while that for H(2) formation decreases from 20.4 to about 16 kcal·mol(–1). …”
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    Enhanced Effect of an External Electric Field on NH(3)BH(3) Dehydrogenation: an AIMD Study for Thermolysis
  14. 3854
    por Symons, Xavier
    Publicado 2022
    “…Conscience is an idea that has significant currency in liberal democratic societies. Yet contemporary moral philosophical scholarship on conscience is surprisingly sparse. …”
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    Why Conscience Matters: A Theory of Conscience and Its Relevance to Conscientious Objection in Medicine
  15. 3855
    “…In the food industry, enzymatic hydrolysis is the most common technique employed for the liberation of BPs from proteins in which conventional heat treatment is used as pre-treatment to enhance hydrolytic action. …”
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    Enhancing the Biological Activities of Food Protein-Derived Peptides Using Non-Thermal Technologies: A Review
  16. 3856
    “…The HV electric-pulse application shows a good possibility of achieving a high energy efficiency with the size reduction and selective liberation of minerals from rocks. The electric and dielectric properties were first measured, and the mineral compositions were also determined by using a micro-X-ray fluorescence spectrometer. …”
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    Equivalent Circuit Models: An Effective Tool to Simulate Electric/Dielectric Properties of Ores—An Example Using Granite
  17. 3857
    “…Due to their time‐consuming nature, enzymatic methods for liberation of single muscle fibers with fully quiescent MuSCs are challenging. …”
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    Visualization of the Skeletal Muscle Stem Cell Niche in Fiber Bundles
  18. 3858
    por So, Derek
    Publicado 2021
    “…In comparison with earlier images of germline modification, they also suggest a more contemporary, Western, and politically liberal social context for gene editing technology. …”
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    From goodness to good looks: Changing images of human germline genetic modification
  19. 3859
    “…We argue this may be linked to its higher level of inequality typical of liberal labour markets.…”
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    Fatherhood and wage inequality in Britain, Finland, and Germany
  20. 3860
    por Carslaw, Nicola, Shaw, David
    Publicado 2022
    “…Cleaning products contain numerous individual chemicals, which can be liberated on use. These species can react in air to form new chemical species, some of which are harmful to health. …”
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    Modification of cleaning product formulations could improve indoor air quality
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