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  1. 4921
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    First-in-human, dose-escalation, phase 1 study of anti-angiopoietin-2 LY3127804 as monotherapy and in combination with ramucirumab in patients with advanced solid tumours
  2. 4922
    “…AIMS: With increased liberalization of cannabis policies in North America, there is growing interest in the use of cannabis to manage pain instead of opioids. …”
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    Legal status of recreational cannabis and self-reported substitution of cannabis for opioids or prescription pain medication in Canada and the United States
  3. 4923
    “…The purpose of this study was to reveal the place that the concept of gender occupies in medical education in Turkey by canvassing the opinions of final-year medical students regarding theories of gender roles and socialization, academic capitalism, and liberal feminism. METHODS: This study was a Cross-sectional survey. …”
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    Gender in Medical Education in Turkey: The Intern Perspective
  4. 4924
    “…Gene e encodes the well-known T4 lysozyme (commonly called T4L) that functions to break the peptidoglycan layer late in the infection cycle, which is required for liberating newly assembled phage progeny. Gene product 5 (gp5) is the tail-associated lysozyme, a component of the phage particle. …”
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    Structure and Function of the T4 Spackle Protein Gp61.3
  5. 4925
    “…The activity of the ATPase was assayed by measuring the amount of inorganic phosphate liberated in the presence and absence of ouabain. The enhanced activity of the ATPase was not observed when EP4 receptors were blocked but still appeared in presence inhibitors of EP1, EP2 and EP3 receptors. …”
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    PGE2 upregulates the Na(+)/K(+) ATPase in HepG2 cells via EP4 receptors and intracellular calcium
  6. 4926
    “…TSLP-assisted histamine liberation triggered by compound 48/80 or Substance P, two canonical MRGPRX2 agonists, was accompanied by an increase in CD107a+ cells (a MC activation marker). …”
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    Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK
  7. 4927
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    Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells
  8. 4928
    “…A region of the Spike protein of the virus, identified as the “fusion peptide” (FP), is liberated at its N-terminal site by a specific cleavage occurring in concert with the interaction of the receptor-binding domain of the Spike. …”
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    Ca(2+)-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide
  9. 4929
    por Lin, Young-Jen, Ho, Cheng-Maw
    Publicado 2021
    “…The importance of this is to liberate surgical resilience in hepatocellular carcinoma. …”
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    Is the Rationale of Anatomical Liver Resection for Hepatocellular Carcinoma Universally Adoptable? A Hypothesis-Driven Review
  10. 4930
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    Transition to Multidisciplinary Pediatric Telerehabilitation during the COVID-19 Pandemic: Strategy Development and Implementation
  11. 4931
    “…More countries are legalizing the commercial production and sale of cannabis for medicinal use, and some for recreational use as well. Liberalization of cannabis laws has led to increased incidence of toxicity, hyperemesis syndrome, lung disease cardiovascular disease, reduced fertility, tolerance, and dependence with chronic prolonged use. …”
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    Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses
  12. 4932
    “…Traditionally, lipolysis has been regarded as an enzymatic activity that liberates fatty acids as metabolic fuel. However, recent work has shown that novel substrates, including a variety of lipid compounds such as fatty acids and their derivatives, release lipolysis products that act as signaling molecules and transcriptional modulators. …”
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    ATGL activity regulates GLUT1-mediated glucose uptake and lactate production via TXNIP stability in adipocytes
  13. 4933
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    The Role of Perspective Taking and Self-Control in a Preventive Intervention Targeting Childhood Disruptive Behavior
  14. 4934
    “…Eligibility criteria were most stringent in the SAFE MANTA study (38% of patients) whereas the MARVEL registry applied liberal and only relative exclusion criteria (56% of patients). …”
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    Data on plug-based large-bore arteriotomy vascular closure device related access complications
  15. 4935
    “…CONCLUSION: Administration ofS. guineense in rats at a dose of 1000 mg/kg body weight affected the food consumption, weight gain, and serum levels of liver and kidney enzymes suggesting that S. guineense intake at high doses may be toxic. Therefore, liberal consumption of S. guineense leaves should be taken curiously and cautiously.…”
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    Sub-chronic toxicity of ethanol leaf extract of Syzygium guineense on the biochemical parameters and histopathology of liver and kidney in the rats
  16. 4936
    “…The acquisition and liberation of heme iron are especially important for the survival of pathogenic bacteria. …”
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    A noncanonical heme oxygenase specific for the degradation of c-type heme
  17. 4937
    “…Participants who were younger, were planning or trying to conceive, had a family member or friend with infertility, and/or had a more liberal political outlook were more likely to support infertility policies. …”
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    Condition, disease, disability: how the label used to describe infertility may affect public support for fertility treatment coverage
  18. 4938
    “…Treatment with botulinum toxin liberated women from excessive sweating and removed a social handicap they described living with. …”
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    ‘Excessive sweating is not a feminine thing’: A qualitative study of women’s experiences suffering from primary hyperhidrosis
  19. 4939
    “…Factor XII (FXII, Hageman factor)-independent- and -dependent activation of prekallikrein to kallikrein leads to the liberation of bradykinin (BK) from high-molecular-weight kininogen (HK). …”
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    Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs
  20. 4940
    “…This cascade of reactions can lead to prolonged high oxidative stress and cause continuous cancer cell apoptosis, due to the increased ROS level and the liberation of CPT. Conclusion: We constructed an ATP-triggered strategy using nanoscale ZIF-90 to initiate mitochondrial cascade reactions for cancer therapy. …”
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    ATP-triggered mitochondrial cascade reactions for cancer therapy with nanoscale zeolitic imidazole framework-90
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