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681por Nilsson, Caroline Ulfsdotter, Bentzer, Peter, Andersson, Linnéa E., Björkman, Sofia A., Hanssson, Fredrik P., Kander, Thomas“…CONCLUSIONS: Low-grade RBC transfusion during the first 5 days of admission was associated with increased mortality and morbidity in a liberal transfusion setting. The results support the current practice of a restrictive transfusion strategy in septic critically ill patients.…”
Publicado 2020
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683por Bäz, Laura, Roßberg, Michelle, Grün, Katja, Kretzschmar, Daniel, Berndt, Alexander, Schulze, P. Christian, Jung, Christian, Franz, Marcus“…Key steps of PH pathogenesis are vascular and right ventricular myocardial remodelling entailing the re-occurrence of fetal variants of the cell adhesion modulating protein fibronectin (Fn) being virtually absent in healthy adult tissues. These variants are liberated into circulation and are therefore qualified as excellent novel serum biomarkers. …”
Publicado 2021
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684“…BACKGROUND: Public health concerns relating to international investment liberalization have centred on the potential for investor-state dispute settlement (ISDS)-related regulatory chill. …”
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685por Ahmed Ali, Ahmed Talaat, Abd EL-Aziz, Mervat Anwar, Mohamed Abdelhafez, Ahmed, Ahmed Thabet, Amr Mohamed“…CONCLUSION: Midodrine and minirin accelerated liberation from intravenous noradrenaline and effective in reducing the ICU length of stay in patients with spinal shock.…”
Publicado 2022
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686por Chang, Irene, Thomas, Karen, O'Neill Gutierrez, Lauran, Peters, Sam, Agbeko, Rachel, Au, Carly, Draper, Elizabeth, Jones, Gareth A. L., Major, Lee Elliot, Orzol, Marzena, Pappachan, John, Ramnarayan, Padmanabhan, Ray, Samiran, Sadique, Zia, Gould, Doug W., Harrison, David A., Rowan, Kathryn M., Mouncey, Paul R., Peters, Mark J.“…MEASUREMENTS AND MAIN RESULTS: Randomization is 1:1 to a liberal Spo(2) target of more than 94% or a conservative Spo(2) target of 88–92% (inclusive), using minimization with a random component. …”
Publicado 2022
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687“…RESULTS: Three hundred and ninety-one patients were included, of whom 66% received eABT. eABT was associated with a lower probability of successful liberation from mechanical ventilation when accounting for the competing risk of death in multivariate analyses (SHR 0.71 [95% confidence interval, 0.57–0.89], p < 0.01), after adjustment with covariates of disease severity. …”
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693“…It was found that the membranes always contained relatively more non-infectious hemagglutinins (NIHA) than the media and, correspondingly, the ratios between infectious virus and hemagglutinin units (ID(50)/HA) in the tissues were up to 1.5 log(10) units lower than in the liberated progeny. These differences were seen not only following inoculation of undiluted ST, ΔST, and UP seeds, the progenies of which always contain considerable proportions of NIHA, but also when dilute ST inocula were employed which lead to the liberation of only infectious virus. …”
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695por Reich, K., Gooderham, M., Bewley, A., Green, L., Soung, J., Petric, R., Marcsisin, J., Cirulli, J., Chen, R., Piguet, V.“…OBJECTIVE: To evaluate long‐term efficacy and safety of apremilast in biologic‐naive patients with moderate to severe plaque psoriasis and safety of switching from etanercept to apremilast in the phase 3b LIBERATE trial. METHODS: Two hundred fifty patients were randomized to placebo, apremilast 30 mg BID or etanercept 50 mg QW through Week 16; thereafter, all patients continued or switched to apremilast through Week 104 (extension phase). …”
Publicado 2018
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696por van Vliet, Danique, van der Goot, Els, van Ginkel, Wiggert G., van Faassen, Martijn H. J. R., de Blaauw, Pim, Kema, Ido P., Martinez, Aurora, Heiner-Fokkema, M. Rebecca, van der Zee, Eddy A., van Spronsen, Francjan J.“…To determine the additive value of LNAA supplementation to a liberalized phenylalanine-restricted diet, brain and plasma monoamine and amino acid concentrations in 10 to 16-month-old adult C57Bl/6 PKU mice on a less severe phenylalanine-restricted diet with LNAA supplementation were compared to those on a non-supplemented severe or less severe phenylalanine-restricted diet. …”
Publicado 2019
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697por Everett, Colin C, Reynolds, Catherine, Fernandez, Catherine, Stocken, Deborah D, Sharples, Linda D, Sathyapalan, Thozhukat, Heller, Simon, Storey, Robert F, Ajjan, Ramzi A“…We describe the design of the LIBERATES trial that investigates the role of flash glucose monitoring in optimising glycaemic markers in high vascular risk individuals with T2D. …”
Publicado 2020
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698por Scaramuzzo, Gaetano, Gamberini, Lorenzo, Tonetti, Tommaso, Zani, Gianluca, Ottaviani, Irene, Mazzoli, Carlo Alberto, Capozzi, Chiara, Giampalma, Emanuela, Bacchi Reggiani, Maria Letizia, Bertellini, Elisabetta, Castelli, Andrea, Cavalli, Irene, Colombo, Davide, Crimaldi, Federico, Damiani, Federica, Fusari, Maurizio, Gamberini, Emiliano, Gordini, Giovanni, Laici, Cristiana, Lanza, Maria Concetta, Leo, Mirco, Marudi, Andrea, Nardi, Giuseppe, Papa, Raffaella, Potalivo, Antonella, Russo, Emanuele, Taddei, Stefania, Consales, Guglielmo, Cappellini, Iacopo, Ranieri, Vito Marco, Volta, Carlo Alberto, Guerin, Claude, Spadaro, Savino“…Moreover, oxygenation response after the first PP was independently associated to liberation from mechanical ventilation at 28 days and was increasingly higher being higher the oxygenation response to PP. …”
Publicado 2021
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699por Schol, Pim B. B., de Lange, Natascha M., Woiski, Mallory D., Langenveld, Josje, Smits, Luc J. M., Wassen, Martine M., Henskens, Yvonne M., Scheepers, Hubertina C. J.“…BACKGROUND: Evidence for optimal hemostatic resuscitation in postpartum hemorrhage (PPH) is lacking. Liberal fluid administration may result in acidosis, hypothermia and coagulopathy. …”
Publicado 2021
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700por Su, Zhijian, Pan, Chao, Xie, Honghui, Ning, Yanyang, Li, Shuangjiang, Xiao, HaiboEnlace del recurso
Publicado 2022
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