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361por Markham, Anthony“…Based on results from the phase I/II LIBRETTO-001 trial, selpercatinib was recently approved by the US FDA for the treatment of RET fusion-positive non-small-cell lung cancer, RET fusion-positive thyroid cancer and RET-mutant medullary thyroid cancer. …”
Publicado 2020
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368por Espíndola Mata, Laura Elizabeth“…The author uses unpublished historical archives to establish Girolamo Giusti as the true playwright of the libretto Motezuma, addressing the motives and sources that could have lead to the creation of this opera with an Indigenous-American theme. …”
Publicado 2020
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373por Ereditato, Antonio“…Ci guida nella costruzione di una caravella spaziale, assembla un equipaggio capitanato da un’intelligenza artificiale, mette in valigia la relatività einsteiniana, l’antimateria, le leggi fondamentali e gli esperimenti realizzati con gli acceleratori di particelle, scrivendo un libretto d’istruzioni comprensibile a tutti. Poi si parte: tappa dopo tappa, sull’imperscrutabile Luna, tra le stelle che illuminano i nostri sogni, a due passi dal Sole, sulla soglia perigliosa di un buco nero, oltre i confini del Sistema Solare, ai margini impossibili dell’Universo. …”
Publicado 2019
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374por Dias-Santagata, Dora, Lennerz, Jochen K., Sadow, Peter M., Frazier, Ryan P., Govinda Raju, Sandya, Henry, Dahlia, Chung, Trisha, Kherani, Jennifer, Rothenberg, S. Michael, Wirth, Lori J.“…The patient enrolled in LIBRETTO-001, a phase I/II trial of the potent and specific RET inhibitor, LOXO-292. …”
Publicado 2020
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375por Scattolin, Daniela, Scagliori, Elena, Scapinello, Antonio, Fantin, Alberto, Guarneri, Valentina, Pasello, Giulia“…Because of the results of the study LIBRETTO-001, selpercatinib has been approved as the first-line treatment for patients with RET fusion–positive advanced NSCLC. …”
Publicado 2023
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376por Drusbosky, Leylah M., Rodriguez, Estelamari, Dawar, Richa, Ikpeazu, Chukwuemeka V.“…Recently, the results from the LIBRETTO-001 and ARROW clinical trials demonstrated significant clinical benefits with selpercatinib and pralsetinib respectively, in NSCLC patients with RET gene fusions, with tolerable toxicity profiles. …”
Publicado 2021
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377por Tsang, Venessa, Gill, Anthony, Gild, Matti, Lurie, Brett, Blumer, Lucy, Siddall, Rhonda, Clifton-Bligh, Roderick, Robinson, Bruce“…METHODS: Sequential patients enrolled in LIBRETTO-001 at Royal North Shore Hospital, Sydney, Australia, with available imaging (n = 22) were recruited. …”
Publicado 2022
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378por Bond, Elizabeth, Shashpal, FNU, Mian, Zainab, Fernandes, Jyotika, Schandl, Cynthia“…He is currently participating in the phase two trial, “LIBRETTO-001" for the RET inhibitor Loxo-292, with the goal of decreasing tumor burden. …”
Publicado 2019
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379por Konda, Bhavana, Massarelli, Erminia, Wright, Jennifer, Soldatenkova, Victoria, Clifton-Bligh, Roderick“…Described are the initial 3 PHEO patients treated with selpercatinib (LIBRETTO-001/NCT03157128). Case 1: 70-year-old white male with MEN2A and a history of medullary thyroid cancer (MTC) and PHEO s/p thyroidectomy and adrenalectomy, received MIBG in 1991 and 2016 due to symptom reoccurrence. …”
Publicado 2021
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380por Cabanillas, Maria E, Wirth, Lori J, Sherman, Eric J, Drilon, Alexander, Solomon, Benjamin, Robinson, Bruce G, Lorch, Jochen H, McCoach, Caroline, Patel, Jyoti, Leboulleux, Sophie, Worden, Francis, Owonikoko, Taofeek K, Brose, Marcia S, Taylor, Matthew H, Subbiah, Vivek, Rothenberg, S Michael, Huang, Xin, Zhu, Edward, French, Pearl P, Shah, Manisha H“…In a first-in-human, phase 1/2 clinical trial (LIBRETTO-001, NCT03157128), selpercatinib (LOXO-292), an investigational, highly selective, potent small molecule RET kinase inhibitor, demonstrated significant and durable anti-tumor activity in patients with advanced RET-mutant MTC or with diverse RET fusion-positive cancers (1). …”
Publicado 2020
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