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41por Wu, Lin, Cheng, Ying, Huang, Dingzhi, Sun, Yuping, Zhou, Chengzhi, Zhou, Jianying, Guo, Ye, Shao, Jingxin, Zhang, Wanli, Lu, Shun“…We report a case of RET/EGFR mutant NSCLC successfully treated with the oral, potent, highly selective RET inhibitor selpercatinib (160 mg daily for 28-day cycles) in an ongoing phase II study in Chinese patients with NSCLC (LIBRETTO-321). The patient, a female nonsmoker, was diagnosed with de-novo left lung adenocarcinoma with neuroendocrine differentiation, and a RET fusion was detected by next-generation sequencing testing. …”
Publicado 2023
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58por Lu, Shun, Zheng, Xiangqian, Sun, Yuping, Huang, Dingzhi, Wu, Lin, Ji, Qinghai, Zhou, Chengzhi, Zhou, Jianying, Guo, Ye, Ge, Minghua, Ding, Ding, Shao, Jingxin, Zhang, Wanli, Gao, Ming, Cheng, Ying“…OBJECTIVES: We report PROs and health-related quality of life (HRQoL) with selpercatinib treatment among Chinese patients with rearranged in transfection (RET) fusion-positive non-small-cell lung cancer (NSCLC), RET fusion-positive thyroid cancer (TC), and RET-mutant medullary TC (MTC) as an exploratory analysis of the LIBRETTO-321 trial. DESIGN: A total of 77 patients (47 RET fusion-positive NSCLC, 1 RET fusion-positive TC, and 29 RET-mutant MTC) were enrolled. …”
Publicado 2023
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