“…Gene regulatory cascades (GRCs) are common motifs in cellular molecular networks. A given logical function in these cascades, such as the repression of the activity of a transcription factor, can be implemented by a number of different regulatory mechanisms. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hence, diabetic therapies which are both “cardio-renal” protective seem the logical way forward. In this review, we discuss the dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4inh), which are glucose-lowering agents used clinically and their role in diabetic kidney disease with specific focus on renoprotection and surrogate markers of cardiovascular disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The master Boolean network (BN) is a deterministic BN, while the slave BN is determined by a series of possible logical functions with certain probability at each discrete time point. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Given that most cellular functions as well as maintenance of the epithelial barrier is energy-dependent, it is logical to assume that mitochondrial dysfunction may play a key role in both the onset and recurrence of disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Subcutaneous drug implants are convenient systems for the long-term delivery of drugs in animals. Lipid carriers are logical tools because they generally allow for higher doses and low toxicity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Epigenetics, particularly DNA methylation, provide a logical interface for environmental factors to influence the genome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After a critical review of exemplary recent research works on cell-free fiber based scaffolds for in situ TE, including clinical studies, we conclude that in order to make use of the whole range of favors which may be provided by engineered fibrous scaffold systems, there are four main issues which need to be addressed: (1) Logical combination of manufacturing techniques and materials. (2) Biomaterial fiber development. (3) Adaption of textile manufacturing techniques to the demands of scaffolds for regenerative medicine. (4) Incorporation of biological cues (e.g. stem cell homing factors).…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Developing clinically applicable therapies that specifically inhibit FOXM1 activity is a logical next step in biomarker-driven approaches against breast cancer but will not be without its challenges due to the unique properties of this transcription factor.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The complementary loop sequence design allowed the hybridization of different tetrahedrons via kissing-loop interaction, which might be further exploited for nanotechnology applications like cargo transport and logical elements. Importantly, we were able to manipulate the stability of those kissing-loop complexes based on the choice and concentration of cations, the temperature and the number of complementary loops per tetrahedron either at the same or at different vertices. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on these findings, we hypothesize that hydrogen might be an effective therapeutic agent to slow or prevent photoreceptor degeneration in RP retinas. It is a logical step to test hydrogen for therapeutic use in multiple RP animal models, and ultimately in human RP patients.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: This trend is promising because such means of performing medical management appear to be more easily compatible with professional logics; therefore, this could facilitate the engagement of a large proportion of professionals rather than the currently limited number of doctors who are “forced” or willing to take formal management roles.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Neurostimulation therapies therefore, which interfere on some level with that abnormal activity, are a logical approach to treatment. For tinnitus, where the pathological neuronal activity might be associated with auditory and other areas of the brain, interventions using electromagnetic, electrical, or acoustic stimuli separately, or paired electrical and acoustic stimuli, have been proposed as treatments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…How has security policy come to be so deeply imbricated with pharmaceutical logics and solutions? This article captures, maps, and analyses the ‘pharmaceuticalisation’ of security. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The formation of silver nanoparticles in the cell filtrates was confirmed by the passage of laser light, change in the color of cell filtrates, absorption peak at 430 nm in UV-Vis spectra, and atomic force microscopy (AFM). There was a logical relationship between the efficiencies of studied Aspergillus species in the production of silver nanoparticles and their nitrate reductase activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We identified four broad domains: logical reasoning and problem solving, understanding people, communication skills, and biomedical science. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In total, 29 entities were organized in the form of a decision tree in order to help clinicians establish a logical diagnosis by stepwise progression.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There were no group differences in verbal fluency, logical memory, or TMT-A performance. In conclusion, anxiety in PD has a measurable impact on working memory and attentional set-shifting.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We recently described a potential mechanism to abrogate this pro-invasive localised leading edge Rac1 to RhoA switch via manipulation of a negative feedback loop that was revealed by adopting a logical modelling approach. Both challenging dogma and taking a formal, mathematical approach to understanding signalling involved in motility may be vital to harnessing harmful cell migration and preventing metastasis in future research.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Obviously, the recent evolution of smart nano-switches promoted the upgrading of the controlled release system from the simple “separated” switch to the reversible, multifunctional, complicated logical switches and selective switches. Especially the free-blockage switches, which are based on hydrophobic/hydrophilic conversion, have been proposed and designed in the last two years. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We can also view them as representations of a causal structure, a logical process captured in a graph. From a causal perspective, we can ask questions such as whether authors form groups primarily due to their prior shared interest, or if their favourite topics are ‘contagious’ and spread through co-authorship. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso