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  1. 46021
    “…Except for the specificity of cytoplasm segmentation, all metrics outperformed the best baseline models (P < 0.05) with a moderate margin. CONCLUSIONS: The proposed algorithm achieved better performances on cervical cell segmentation than baseline models. …”
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    Online Artículo Texto
    Automated cervical cell segmentation using deep ensemble learning
  2. 46022
    “…From learning phase to proficiency phase, the rate of positions within the safe zone differed only marginally (88.9–100% vs. 85.7–100%) based on a rather low number of patients. …”
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    Online Artículo Texto
    Preliminary study of short-term outcomes and learning curves of robotic-assisted THA: comparison between closed platform robotic system and open platform robotic system
  3. 46023
    “…RESULTS: After controlling for socioeconomic status, the average marginal effect indicated a decrease in mental health among Moroccans and Turks in Belgium between 1997 and 2018, compared to Belgians. …”
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    Online Artículo Texto
    Mental health among people with a migration background in Belgium over the past 20 years: how has the situation evolved?
  4. 46024
    “…For patients with high MVI risk, wide-margin resection or anatomical resection could significantly improve the 2-year recurrence free survival. …”
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    Online Artículo Texto
    A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients
  5. 46025
    “…After propensity score matching, the marginal effect of the new policy on treatment outcome was 2.29 days (standard error, SE: 0.715, P = 0.001) more reduction in MHD, and 30.1% (SE: 10.6%, P = 0.005) increase in ≥ 50% response rate for MHD. …”
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    Online Artículo Texto
    Impact of a reimbursement policy change on treatment with erenumab in migraine – a real-world experience from Germany
  6. 46026
    “…RESULTS: Anonymization affected the baseline characteristics of potential confounders only marginally. The greatest difference was in the prevalence of chronic obstructive pulmonary disease (4.6% vs. 5.4% in the pseudonymized compared to the anonymized data, respectively). …”
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    Online Artículo Texto
    Utilization of anonymization techniques to create an external control arm for clinical trial data
  7. 46027
    “…Almost all patients underwent surgical excision (n = 15, 94%) with negative resection margin and no major post-operative complications. …”
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    Online Artículo Texto
    Maintaining quality of life after major lung resection for carcinoid tumor
  8. 46028
    “…The pathological outcomes included pathological T stage (pT2 vs. pT3–4) and positive surgical margins (PSMs). Patients were further stratified according to statistically significant preoperative variables to assess the difference in pathological outcomes. …”
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    Effect of preoperative PI-RADS assessment on pathological outcomes in patients who underwent radical prostatectomy
  9. 46029
    “…In both univariate and multivariate analysis, the p53−/BAX high in comparison with the p53+/BAX high subset conferred a significantly improved DFS (P=0.03 and P=0.03, respectively) as well as a marginally improved OS (P=0.07 and P=0.08, respectively). …”
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    Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX
  10. 46030
    “…Subjects with a cholecystectomy at least 20 years prior to the diagnosis of pancreatic cancer experienced a 70% increased risk, which was marginally significant. In contrast, subjects with a history of duodenal or gastric ulcer had little or no elevated risk (OR = 1.2; confidence interval = 0.9–1.6). …”
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    Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer
  11. 46031
    “…‘Frequent’ alcohol consumption, on its own, caused a marginally elevated risk for oesophageal cancer (odds ratio=1.7, 95% CI 1.0–2.9, for women and odds ratio=1.8, 95% CI 1.2–2.8, for men). …”
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    Risk factors for oesophageal, lung, oral and laryngeal cancers in black South Africans
  12. 46032
    “…It had no significant efficacy based on the primary endpoint, clinical malaria, but marginal efficacy against clinical malaria in secondary analyses, and high allele-specific efficacy. …”
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    Extended Safety, Immunogenicity and Efficacy of a Blood-Stage Malaria Vaccine in Malian Children: 24-Month Follow-Up of a Randomized, Double-Blinded Phase 2 Trial
  13. 46033
    “…Patients with LNs present in the PAFP had a higher incidence of biopsy Gleason score (GS) 8–10, pathologic N1 disease, and positive surgical margin in prostatectomy specimens than those with no LNs detected in the PAFP. …”
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    Oncologic outcomes in men with metastasis to the prostatic anterior fat pad lymph nodes: a multi-institution international study
  14. 46034
    por Koullali, Bouchra, van Kempen, Liselotte E.M., van Zijl, Maud D., Naaktgeboren, Christiana A., Schuit, Ewoud, Bekedam, Dick J., Franssen, Maureen T.M., Nij Bijvank, Sebastiaan W.A., Sueters, Marieke, van Baal, Marchien, de Boer, Marjon A., Hooker, Angelo B., Hermsen, Brenda B.J., Toolenaar, Toon A.A.M., Zwart, Joost J., van der Ham, David P., van der Made, Flip W., Prefumo, Federico, Martinez de Tejada, Begoña, Papatsonis, Dimitri N.M., Huisjes, Anjoke J.M., Scheepers, Liesbeth H.C.J., van Hoorn, Marion E., Hasaart, Tom H.M., Schuitemaker, Nico W.E., Vollebregt, Karlijn C., Müller, Moira A., Evers, Inge M., Post, Marinka S., de Boer, Karin, Visser, Henricus, Mensing van Charante, Nico A., Langenveld, Josje, Steemers, Nicole Y.C., Mol, Ben W.J., Oudijk, Martijn A., Pajkrt, Eva
    Publicado 2017
    “…We assume an event rate of 20% preterm birth before 32 weeks for cerclage and use a non-inferiority margin of 10% for the cervical pessary. Using an alpha of 0.05 and power of 0.80 we need 2 groups of 200 women each. …”
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    Online Artículo Texto
    A multi-centre, non-inferiority, randomised controlled trial to compare a cervical pessary with a cervical cerclage in the prevention of preterm delivery in women with short cervical length and a history of preterm birth – PC study
  15. 46035
    por Weinblatt, Michael E., Baranauskaite, Asta, Niebrzydowski, Jaroslaw, Dokoupilova, Eva, Zielinska, Agnieszka, Jaworski, Janusz, Racewicz, Artur, Pileckyte, Margarita, Jedrychowicz‐Rosiak, Krystyna, Cheong, Soo Yeon, Ghil, Jeehoon, Sokolovic, S., Mekic, M., Prodanovic, N., Gajic, B., Karaselimovic‐Dzambasovic, E., Pojskic, B., Toncheva, A., Dimitar, P., Rodina, L., Geneva‐Popova, M., Staykov, I., Stoilov, R., Podrazilova, L., Mosterova, Z., Simkova, G., Kopackova, J., Stejfova, Z., Vencovsky, J., Urbanova, Z., Janska, L., Galatíkova, D., Stropuviene, S., Sniuoliene, I., Sitek‐Ziolkowska, K., Rell‐Bakalarska, M., Kolasa, R., Daniluk, S., Sliwowska, B., Bartosik‐Twardowska, M., Brzezicki, J., Konieczny, M., Jeka, S., Choe, J., Bae, S., Kang, Y., Prystupa, L., Vyacheslav, Z., Gasanov, I., Yatsyshyn, R., Rekalov, D., Iaremenko, O., Stanislavchuk, M., Tseluyko, V.
    Publicado 2017
    “…The ACR20 response rate at week 24 in the per‐protocol set was equivalent between those receiving SB5 and those receiving reference ADA (72.4% and 72.2%, respectively); the difference in the ACR20 response rate (0.1%, [95% confidence interval −7.83%, 8.13%]) was within the predefined equivalence margin (±15%). Similar results were seen in the full analysis set (missing data being considered a nonresponse). …”
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    Phase III Randomized Study of SB5, an Adalimumab Biosimilar, Versus Reference Adalimumab in Patients With Moderate‐to‐Severe Rheumatoid Arthritis
  16. 46036
    por van den Boom, Anne Loes, de Wijkerslooth, Elisabeth M. L., van Rosmalen, Joost, Beverdam, Frédérique H., Boerma, Evert-Jan G., Boermeester, Marja A., Bosmans, Joanna W. A. M., Burghgraef, Thijs A., Consten, Esther C. J., Dawson, Imro, Dekker, Jan Willem T., Emous, Marloes, van Geloven, Anna A. W., Go, Peter M. N. Y. H., Heijnen, Luc A., Huisman, Sander A., Jean Pierre, Dayanara, de Jonge, Joske, Kloeze, Jurian H., Koopmanschap, Marc A., Langeveld, Hester R., Luyer, Misha D. P., Melles, Damian C., Mouton, Johan W., van der Ploeg, Augustinus P. T., Poelmann, Floris B., Ponten, Jeroen E. H., van Rossem, Charles C., Schreurs, Wilhelmina H., Shapiro, Joël, Steenvoorde, Pascal, Toorenvliet, Boudewijn R., Verhelst, Joost, Versteegh, Hendt P., Wijnen, Rene M. H., Wijnhoven, Bas P. L.
    Publicado 2018
    “…Secondary outcomes include IAA, SSI, restart of antibiotics, length of hospital stay (LOS), reoperation, percutaneous drainage, readmission rate, and cost-effectiveness. The non-inferiority margin for the difference in the primary endpoint rate is set at 7.5% (one-sided test at ɑ 0.025). …”
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    Two versus five days of antibiotics after appendectomy for complex acute appendicitis (APPIC): study protocol for a randomized controlled trial
  17. 46037
    “…Among the 21 tested SNPs, 16 showed the same direction of allelic effects in our samples compared with previous studies; 6 SNPs achieved nominal significance (p < 0.05) at one-tailed test, and 2 additional SNPs showed marginal significance (p < 0.10). Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans. …”
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    Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population
  18. 46038
    “…With a non-inferiority margin of 9% and an expected loss to follow-up of 10%, 424 women will be needed to prove non-inferiority with a confidence interval of 95%. …”
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    Evaluation of two vaginal, uterus sparing operations for pelvic organ prolapse: modified Manchester operation (MM) and sacrospinous hysteropexy (SSH), a study protocol for a multicentre randomized non-inferiority trial (the SAM study)
  19. 46039
    “…Intention-to-treat analysis of the primary endpoint will be performed with a marginal Cox proportional hazard model. Prospective power calculations indicate that the study will have 90% statistical power to detect a clinical significant two-fold increase in median infection-free survival if 200 patients are recruited into each arm over a period of 24 months. …”
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    Evaluation of the efficacy of an interdialytic “ethanol 40% v/v - enoxaparin 1000 U/mL” lock solution to prevent tunnelled catheter infections in chronic hemodialysis patients: a multi-centre, randomized, single blind, parallel group study
  20. 46040
    “…Receipt of weekly recommendations resulted in a significantly higher number of app use sessions during treatment (overall median=216; P=.04) but only marginal effects for time to last use (P=.06) and number of app downloads (P=.08). …”
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    Comparison of the Effects of Coaching and Receipt of App Recommendations on Depression, Anxiety, and Engagement in the IntelliCare Platform: Factorial Randomized Controlled Trial
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