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  1. 46141
    “…Clustered conditional logit models were used to estimate treatment preferences, and marginal rates of substitution were used to estimate disutilities. …”
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    Online Artículo Texto
    Preferences and Utilities for Treatment Attributes in Type 2 and Non-ambulatory Type 3 Spinal Muscular Atrophy in the United Kingdom
  2. 46142
    “…RESULTS: In the dMMR/MSI-H GAC, the number of mutated genes in the PI3K-AKT-mTOR pathway (NMP) was positively correlated with tumor mutational burden (P < 0.001) and sensitivity to PI3K-AKT-mTOR inhibitors and negatively correlated with CD3(+) (P < 0.001), CD4(+) (P = 0.065), CD8(+) (P = 0.004), and FOXP3(+) cells (P = 0.033) in the central-tumor rather than invasive-margin area, and the transcription of immune-related genes. …”
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    Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma
  3. 46143
    “…RESULTS: The TEM analysis represented round shape NeO-SLNs with clear and stable margins. DLS analysis showed a mean particle size 337.6 nm for SLNs, and most of nanoparticles were in range 30 to 120 nm. …”
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    Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity
  4. 46144
    “…In the SH&WH cohort, the interactions between ctDNA-adjusted bTMB and treatment were marginally significant for OS (interaction P = 0.081) and PFS (interaction P = 0.062). …”
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    ctDNA-adjusted bTMB as a predictive biomarker for patients with NSCLC treated with PD-(L)1 inhibitors
  5. 46145
    “…Median bone mineral density (BMD) for the whole group was 300.04 ± 226.02 mg/cm(3) (range − 88.68 to 555.06 mg/cm(3)) for region of interest (ROI 5) (central), 214.80 ± 167.45 mg/cm(3) (range − 7.16 to 597.21 mg/cm(3)) for ROI 1–4 (marginal zones: medial, lateral, ventral, dorsal) and 168.14 ± 65.54 mg/cm(3) (range 17.47–208.97 mg/cm(3)) for healthy bone tissue (femur and tibia). …”
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    Radiographic and clinical outcome of tibial plateau fractures treated with bone allograft
  6. 46146
    “…The OR of hyperglycemic emergency was also elevated in winter season at OR of 1.88, but the significance is only marginal (95% CI 0.97–3.64, p = 0.0598). Subgroup analyses further noted that such seasonal variation was also observed in pregnancies with pre-pregnancy type 1 diabetes and gestational diabetes. …”
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    Associations of hyperglycemic emergency and severe hypoglycemia incidences with seasonality and ambient temperature among pregnant women with diabetes: a nested case-control study in Taiwan
  7. 46147
    por Ng, Chun Wai, Wong, Kwong-Kwok
    Publicado 2022
    “…Random-effects models showed that ER⍺ expression (HR = 0.81, 95% CI = 0.64–1.02) and ERβ expression (HR = 0.75, 95% CI = 0.50–1.13) were only marginally and not significantly associated with better OS. …”
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    Impact of estrogen receptor expression on prognosis of ovarian cancer according to antibody clone used for immunohistochemistry: a meta-analysis
  8. 46148
    “…The histopathological examination showed no viable tumor cell remnants in the primary tumor, which had a grade 3 histological response, and resection margins were negative. The lymph nodes showed mucus retention only in the anterior superior lymph node of the CHA, indicating the presence of metastasis, but no viable tumor cells remained. …”
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    Conversion surgery for microsatellite instability-high gastric cancer with a complete pathological response to pembrolizumab: a case report
  9. 46149
    “…. • Acetazolamide resulted in a marginal inhibitory effect on cell growth.…”
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    The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG
  10. 46150
    “…Variations in the fitness parameters, fecundity and wing length marginally reflected the differences in exposure to agrochemicals and should be investigated further. …”
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    Effects of agricultural pesticides on the susceptibility and fitness of malaria vectors in rural south-eastern Tanzania
  11. 46151
    “…CONCLUSION: This study indicates that 3DMCO with 2 mm margins for organ deformations may be inadequate for Cyberknife-based lung stereotactic body radiotherapy (SBRT). …”
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    Comparison of 3D and 4D Monte Carlo optimization in robotic tracking stereotactic body radiotherapy of lung cancer
  12. 46152
    “…RESULTS: While liver cirrhosis only marginally affected the pharmacokinetics of the low to moderate extraction drugs efavirenz and flurbiprofen, the elimination rate of caffeine was reduced by 51% in patients with Child C cirrhosis. …”
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    Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently
  13. 46153
    “…The upper limit of the bilateral 95% CI was 0.215%, below the 0.40% pre-defined as the non-inferiority margin. Fasting blood glucose, BMI, and adherence were not significantly different between the groups. …”
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    Comparison of the Effectiveness of Once-Daily Alogliptin/Metformin and Twice-Daily Anagliptin/Metformin Combination Tablet in a Randomized, Parallel-Group, Open-Label Trial in Japanese Patients with Type 2 Diabetes
  14. 46154
    “…Those identifying as non-Black or non-White race have a marginally higher risk for mortality (OR 1.101, CI 1.032–1.174) and greater risk of ARDS (OR 1.44, CI 1.334–1.554) when compared to those who identify as White. …”
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    Impact of age, sex, race, and regionality on major clinical outcomes of COVID-19 in hospitalized patients in the United States
  15. 46155
    “…The estimates of age gradient, expressed as ORs, were 1.02 (1.02, 1.02) in males versus 1.05(1.05, 1.06) in females (p < 0.001) in NFHS-SAGE and 1.01(1.01, 1.02) in males versus 1.04(1.03, 1.04)in females (p < 0.001) in LASI;these differences marginally changed after adjustment with BMI. CONCLUSION: This is perhaps the first study to comprehensively demonstrate that cardio-metabolic risk in Indian females surpasses males after 50 years of age, “busting the myth” that Indian females are always at much lower risk than males; and this evidence should inform the Indian healthcare system to prioritise older women for screening and treatment of hypertension. …”
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    Gender difference in prevalence of hypertension among Indians across various age-groups: a report from multiple nationally representative samples
  16. 46156
    “…To determine the efficacy margin for the hazard ratio, tirzepatide versus dulaglutide, for the composite CV outcome of death, myocardial infarction, or stroke (MACE-3), which is required to claim superiority versus an imputed placebo, the lower bound of efficacy of dulaglutide compared with placebo was estimated using a hierarchical Bayesian meta-analysis of placebo-controlled CVOTs of GLP-1 RAs. …”
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    Transitioning to active-controlled trials to evaluate cardiovascular safety and efficacy of medications for type 2 diabetes
  17. 46157
    “…The between-treatment difference in change scores was within the non-inferiority margin of 10 points (−1.2, 95% CI −5.7 to 3.3), suggesting SKY was not inferior to CPT. …”
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    Randomised clinical non-inferiority trial of breathing-based meditation and cognitive processing therapy for symptoms of post-traumatic stress disorder in military veterans
  18. 46158
    por Simpson-Yap, Steve, Pirmani, Ashkan, Kalincik, Tomas, De Brouwer, Edward, Geys, Lotte, Parciak, Tina, Helme, Anne, Rijke, Nick, Hillert, Jan A., Moreau, Yves, Edan, Gilles, Sharmin, Sifat, Spelman, Tim, McBurney, Robert, Schmidt, Hollie, Bergmann, Arnfin B., Braune, Stefan, Stahmann, Alexander, Middleton, Rod M., Salter, Amber, Bebo, Bruce, Van der Walt, Anneke, Butzkueven, Helmut, Ozakbas, Serkan, Boz, Cavit, Karabudak, Rana, Alroughani, Raed, Rojas, Juan I., van der Mei, Ingrid A., Sciascia do Olival, Guilherme, Magyari, Melinda, Alonso, Ricardo N., Nicholas, Richard S., Chertcoff, Anibal S., de Torres, Ana Zabalza, Arrambide, Georgina, Nag, Nupur, Descamps, Annabel, Costers, Lars, Dobson, Ruth, Miller, Aleisha, Rodrigues, Paulo, Prčkovska, Vesna, Comi, Giancarlo, Peeters, Liesbet M.
    Publicado 2022
    “…Compared with glatiramer acetate, ocrelizumab and rituximab were associated with higher probabilities of hospitalization (4% [95% CI 1–7] and 7% [95% CI 4–11]), ICU/artificial ventilation (2% [95% CI 0–4] and 4% [95% CI 2–6]), and death (1% [95% CI 0–2] and 2% [95% CI 1–4]) (predicted marginal effects). Untreated patients had 5% (95% CI 2–8), 3% (95% CI 1–5), and 1% (95% CI 0–3) higher probabilities of the 3 respective levels of COVID-19 severity than glatiramer acetate. …”
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    Updated Results of the COVID-19 in MS Global Data Sharing Initiative: Anti-CD20 and Other Risk Factors Associated With COVID-19 Severity
  19. 46159
    “…The main secondary objectives are long-term oncological outcomes, radiological and pathological response, the number of resections with clear margins, treatment-related toxicity, perioperative complications, health-related costs, and quality of life. …”
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    Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (“ugly”) locally advanced rectal cancer: study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)
  20. 46160
    “…Minimally-invasive cardiac surgery pertaining to valve surgery (n = 42) and coronary artery bypass surgery (n = 30) were the two most frequent topics by a large margin. CONCLUSIONS: This work establishes a comprehensive and informative analysis of the most influential publications in minimally-invasive cardiac surgery and outlines what constitutes a citable article. …”
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    Minimally-invasive cardiac surgery: a bibliometric analysis of impact and force to identify key and facilitating advanced training
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