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46301por Guan, Fiona H. X., Bailey, Charles G., Metierre, Cynthia, O’Young, Patrick, Gao, Dadi, Khoo, Teh Liane, Holst, Jeff, Rasko, John E. J.“…In contrast, ELF2A overexpression only marginally reduced clonogenic capacity with little effect on proliferation, cell cycle progression, or apoptosis. …”
Publicado 2017
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46302por Obonyo, Nchafatso, Brent, Bernadette, Olupot-Olupot, Peter, Boele van Hensbroek, Michael, Kuipers, Irene, Wong, Sidney, Shiino, Kenji, Chan, Jonathan, Fraser, John, van Woensel, Job B. M., Maitland, Kathryn“…In group 2, these variables were more homogenous and typical of FR. Median SVRI marginally decreased post fluid administration (both groups) but remained high at 24 h. …”
Publicado 2017
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46303por Matei, Deliu Victor, Vartolomei, Mihai Dorin, Musi, Gennaro, Renne, Giuseppe, Tringali, Valeria Maria Lucia, Mistretta, Francesco Alessandro, Delor, Maurizio, Russo, Andrea, Cioffi, Antonio, Bianchi, Roberto, Cozzi, Gabriele, Di Trapani, Ettore, Bottero, Danilo, Cordima, Giovanni, Lucarelli, Giuseppe, Ferro, Matteo, de Cobelli, Ottavio“…In sub-group analysis, clamp-less RASE was safe in terms of complications (14.1%), positive surgical margins (1.3%), and mid-term local recurrence (1.3%). …”
Publicado 2017
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46304por Evangelistella, Chiara, Valentini, Alessio, Ludovisi, Riccardo, Firrincieli, Andrea, Fabbrini, Francesco, Scalabrin, Simone, Cattonaro, Federica, Morgante, Michele, Mugnozza, Giuseppe Scarascia, Keurentjes, Joost J. B., Harfouche, Antoine“…This is due to its high productivity, adaptability to marginal land conditions, and suitability for biofuel and biomaterial production. …”
Publicado 2017
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46305por Flasche, Stefan, Ojal, John, Le Polain de Waroux, Olivier, Otiende, Mark, O’Brien, Katherine L., Kiti, Moses, Nokes, D. James, Edmunds, W John, Scott, J. Anthony G.“…We fitted a transmission dynamic model to detailed local data, including nasopharyngeal carriage and invasive pneumococcal disease (IPD), to infer the marginal impact of the PCV catch-up campaign over hypothetical routine cohort vaccination in that setting and to estimate the likely impact of alternative campaigns and their dose efficiency. …”
Publicado 2017
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46306por Négrier, Sylvie, Pérol, David, Bahleda, Rastislav, Hollebecque, Antoine, Chatelut, Etienne, Boyle, Helen, Cassier, Philippe, Metzger, Séverine, Blanc, Ellen, Soria, Jean-Charles, Escudier, Bernard“…CONCLUSIONS: The combination of pazopanib and bevacizumab induces angiogenic toxicity in patients without any pre-existing renal or vascular damage. Even if a marginal efficacy was reported with five (22%) patients in partial response in different tumor types, the toxicity profile compromises the development of this combination. …”
Publicado 2017
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46307por Jiang, Ping, Krockenberger, Katja, Vonthein, Reinhard, Tereszczuk, Jane, Schreiber, Arne, Liebau, Sebastian, Huttenlocher, Stefan, Imhoff, Detlef, Balermpas, Panagiotis, Keller, Christian, Dellas, Kathrin, Baumann, Rene, Rödel, Claus, Hildebrandt, Guido, Jünemann, Klaus-Peter, Merseburger, Alex S., Katz, Alan, Ziegler, Andreas, Blanck, Oliver, Dunst, Jürgen“…The target volume includes the prostate with or without the base of seminal vesicles depending on risk stratification and uncertainty margins that are kept at 3–5 mm. SBRT treatment is delivered with the robotic CyberKnife system, which was recently introduced in Germany. …”
Publicado 2017
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46308por Battersby, Nick J., Dattani, Mit, Rao, Sheela, Cunningham, David, Tait, Diana, Adams, Richard, Moran, Brendan J., Khakoo, Shelize, Tekkis, Paris, Rasheed, Shahnawaz, Mirnezami, Alex, Quirke, Philip, West, Nicholas P., Nagtegaal, Iris, Chong, Irene, Sadanandam, Anguraj, Valeri, Nicola, Thomas, Karen, Frost, Michelle, Brown, Gina“…Secondary endpoints include the rate of unit recruitment, acute drug toxicity, reproducibility of mrTRG reporting, surgical morbidity, pathological circumferential resection margin involvement, pathology regression grade, residual tumour cell density and surgical/specimen quality rates. …”
Publicado 2017
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46309por Karadzovska, Daniela, Chappell, Kimberly, Coble, Shane, Murphy, Martin, Cavalleri, Daniela, Wiseman, Scott, Drake, Jason, Nanchen, Steve“…BACKGROUND: Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelio™, Elanco) administered orally to dogs, produces rapid flea and tick knockdown and sustained speed of kill for at least a month post-treatment with a wide safety margin. A field study was undertaken to validate pre-clinical results. …”
Publicado 2017
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46310por Chen, Ke, Pan, Yu, Liu, Xiao-long, Jiang, Guang-yi, Wu, Di, Maher, Hendi, Cai, Xiu-jun“…Main outcomes were comprehensively reviewed and measured including conversion to open approach, operation time (OP), estimated blood loss (EBL), transfusion, length of hospital stay (LOS), overall complications, postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), post-pancreatectomy hemorrhage (PPH), readmission, reoperation and reasons of preoperative death, number of retrieved lymph nodes (RLN), surgical margins, recurrence, and survival. The software of Review Manage version 5.1 was used for meta-analysis. …”
Publicado 2017
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46311“…Health education had marginal impact on reducing HIV incidence among MMT participants (2013-2020:2.86% to 2.84%) from 2013 to 2020. …”
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46312por Noordman, Bo Jan, Wijnhoven, Bas P. L., Lagarde, Sjoerd M., Boonstra, Jurjen J., Coene, Peter Paul L. O., Dekker, Jan Willem T., Doukas, Michael, van der Gaast, Ate, Heisterkamp, Joos, Kouwenhoven, Ewout A., Nieuwenhuijzen, Grard A. P., Pierie, Jean-Pierre E. N., Rosman, Camiel, van Sandick, Johanna W., van der Sangen, Maurice J. C., Sosef, Meindert N., Spaander, Manon C. W., Valkema, Roelf, van der Zaag, Edwin S., Steyerberg, Ewout W., van Lanschot, J. Jan B.“…A total of 300 patients with clinically complete response (cCR, i.e. no local or disseminated disease proven by histology) after nCRT will be randomised to show non-inferiority of active surveillance to standard oesophagectomy (non-inferiority margin 15%, intra-correlation coefficient 0.02, power 80%, 2-sided α 0.05, 12% drop-out). …”
Publicado 2018
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46313por Hendler, Talma, Raz, Gal, Shimrit, Solnik, Jacob, Yael, Lin, Tamar, Roseman, Leor, Wahid, Wahid Madah, Kremer, Ilana, Kupchik, Marina, Kotler, Moshe, Bleich-Cohen, Maya“…Compared to patients, healthy controls showed higher ES-NCI and marginally lower ToM-NCI during emotional peaks. Cross-correlation analysis revealed an intriguing dynamic between NCI and the inter-group difference of reported fear. …”
Publicado 2018
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46314por Scheerman, Janneke F. M., van Meijel, Berno, van Empelen, Pepijn, Kramer, Gem J. C., Verrips, Gijsbert H. W., Pakpour, Amir H., Van den Braak, Matheus C. T., van Loveren, Cor“…The primary study outcomes are the presence of dental plaque (measured with a modified Silness and Loë Plaque Index); and gingival bleeding (measured with the Bleeding on Marginal Probing Index). Secondary outcomes include changes in self-reported oral-health behaviors and its psychosocial factors identified by the HAPA theory, such as outcome expectancies, intention, action self-efficacy, coping planning and action control. …”
Publicado 2018
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46315por Kansiime, Freddie, Adibaku, Seraphine, Wamboga, Charles, Idi, Franklin, Kato, Charles Drago, Yamuah, Lawrence, Vaillant, Michel, Kioy, Deborah, Olliaro, Piero, Matovu, Enock“…The primary endpoint was the cure rate, determined as the proportion of patients alive and without laboratory signs of infection at 18 months post-treatment, with no demonstrated trypanosomes in the cerebrospinal fluid (CSF), blood or lymph node aspirates, and CSF white blood cell count < 20 /μl. The non-inferiority margin was set at 10%. RESULTS: One hundred and nine patients were enrolled; all contributed to the intent-to-treat (ITT), modified intent-to-treat (mITT) and safety populations, while 105 constituted the per-protocol population (PP). …”
Publicado 2018
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46316por Zhang, L, Lu, S, Feng, J, Dechaphunkul, A, Chang, J, Wang, D, Chessari, S, Lanzarotti, C, Jordan, K, Aapro, M“…Non-inferiority was defined as a lower 95% CI greater than the non-inferiority margin set at − 10%. Secondary efficacy endpoints included no emesis, no rescue medication, and no significant nausea (NSN). …”
Publicado 2018
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46317por Knight, Julia A., Blackmore, Kristina M., Fan, Jing, Malone, Kathleen E., John, Esther M., Lynch, Charles F., Vachon, Celine M., Bernstein, Leslie, Brooks, Jennifer D., Reiner, Anne S., Liang, Xiaolin, Woods, Meghan, Bernstein, Jonine L.“…A decrease of ≥ 10% in %MD between first and second mammogram was associated marginally with reduced risk of CBC (OR 0.63, 95% CI 0.40, 1.01) compared to change of <10%. …”
Publicado 2018
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46318por Hess, Anne Lundby, Carayol, Jérôme, Blædel, Trine, Hager, Jörg, Di Cara, Alessandro, Astrup, Arne, Saris, Wim H. M., Larsen, Lesli Hingstrup, Valsesia, Armand“…RESULTS: Changes in ANGPTL3 during weight loss showed only marginal association with changes in triglycerides (nominal p = 0.02) and insulin (p = 0.04); these results did not remain significant after correcting for multiple testing. …”
Publicado 2018
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46319por Källander, Karin, Alfven, Tobias, Workineh, Ayalkibet Abebe, Hailemariam,, Abreham, Petzold, Max, Getachew, Dawit, Barat, Lawrence, Steinhardt, Laura C, Gutman, Julie R“…To demonstrate that there is no significant increase in the percentage of children deteriorating clinically, the sample size needed for a noninferiority margin of 4%, a power of 80%, an alpha of 5%, and a design effect of 3 is 4284 children with unclassified fever. …”
Publicado 2018
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46320“…RESULTS: Our results show that the SVM model achieved the best average F1-score of 89.1% on test data, outperforming the long short-term memory (LSTM) model with attention (F1-score of 65.72%) as well as the rule induction baseline system (F1-score of 7.47%) by a large margin. The bidirectional LSTM model with attention achieved the best performance among different RNN models. …”
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