“…Clinical presentations may range from subtle non-specific signs and symptoms to multi-organ failure.1 Signs and symptoms suggestive of necrotizing fasciitis include skin necrosis, hemorrhagic bullae, pain out of proportion, and erythema progressing beyond margins.2 Radiographs may show dissecting gas along fascial planes in the absence of trauma, but this is not a sensitive finding and may present late in the disease course. …”
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“…NSEIT demonstrated noninferiority to NSE in the primary outcome NDI, as the 1-sided 95% CI of the mean difference in change did not cross the specified noninferiority margin (7 percentage units). There were no significant between-group differences in change in NDI at the 3- or 15-month follow-up, with a mean difference of 1.4 (95% CI –2.5 to 5.3) and 0.9 (95% CI –3.6 to 5.3), respectively. …”
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“…Among patients treated more recently, tMDS/AML risks were significantly higher after CLL/SLL (SIR(2000-2005) = 4.8, SIR(2012-2017) = 10, P(trend) = 0.0043), significantly lower after Hodgkin (SIR(2000-2005) = 15, SIR(2012-2017) = 6.3, P(trend) = 0.024) and marginal zone (SIR(2000-2005) = 7.5, SIR(2012-2017) = 2.3, P(trend) = 0.015) lymphomas, and non-significantly lower after mantle cell lymphoma (SIR(2000-2005) = 10, SIR(2012-2017) = 3.2, P(trend) = 0.054), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (SIR(2000-2005) = 6.9, SIR(2012-2017) = 1.0, P(trend) = 0.067), and plasma cell neoplasms (SIR(2000-2005) = 5.4, SIR(2012-2017) = 3.1, P(trend) = 0.051). …”
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“…Sodic soil reclamation using inorganic ameliorants like mineral gypsum or phosphogypsum is beyond the reach of small and marginal farmers having alkali soils because of their higher market prices and shortage of availability. …”
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“…In contrast, T cells are marginally affected by antigen evolution although they represent the major mediators of virus control and vaccine protection against virus-induced disease. …”
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“…Information about histological margins, MC, Ki67 index, local recurrence, nodal relapse, distant metastasis, de novo cMCT occurrence and date and cause of death were included. …”
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“…The first part estimated marginal probability of a claim in a given month with a probit model, comparing PAP users and nonusers, whereas the second part estimated days supplied of a medication, given a claim was made as a measure for demand. …”
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“…Safety was assessed in patients with at least one cycle of assigned treatment. The non‐inferiority margin was ‐8%. RESULTS: A total of 287 patients were included in the intention‐to‐treat analysis, the median follow‐up was 47.3 months, and the 2‐year PFS rate was 95% (95% confidence interval [CI], 92% to 99%) and 94% (95% CI, 91% to 98%) for the 4R‐CHOP+4R and 6R‐CHOP+2R arm. …”
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“…The tendon was repaired in an arthroscopic manner by utilizing the single-row technique at the medial margin of the lesser tuberosity. One double-loaded suture SwiveLock(®) C anchor was applied to achieve a strong fixation between the footprint and tendon. …”
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“…We use inverse probability by treatment weighting (IPTW) applied to difference-in-differences marginal structural models to estimate the treatment effect using a modified intent-to-treat approach. …”
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“…The results of this study suggest that due to a reduction in the capsule shell’s resistance to abrasion, treated capsules marginally prevented the release of fish oil in the rumen.…”
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“…Nivolumab plus ipilimumab combination therapy was associated with marginal, but not clinically meaningful, improvement in PFS over nivolumab alone (pooled HR, 0.88; 95% CI, 0.79-0.98; P = .02). …”
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“…CONCLUSIONS: In community dwelling adults with early covid-19, PEP flute self-care had a significant, yet marginal and uncertain clinical effect on respiratory symptom severity, as measured by CAT scores. …”
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“…A total 25(OH)D of <15.14 ng/mL was marginally associated with a higher risk of reduced high-density lipoprotein cholesterol (HDL-C) [odd ratios (OR) = 1.371 (0.991–1.899)]. …”
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“…Imaging of the pancreas with computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound revealed a 1.2x0.8cm nodule on the superior margin of the body of the pancreas. (68)Ga-DOTATATE​​ PET/CT (targeting somatostatin receptors) showed mild uptake coinciding with the nodule on the CT scan. …”
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“…A repeat neck US identified a solid vascular 1.6 cm nodule along the anterior margin of the superior left thyroid lobe. Some vascularity was extending from the thyroid tissue into the nodule. …”
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“…Interesting, in the presence of CAN1405, signaling of the mutFSHR I423T was marginal in terms of activation of the pSOMLuc reporter but not of pERK1/2, suggesting that binding of CAN1405 to the mutFSHR changed the conformation of the receptor allowing functional selectivity on FSH-stimulated signaling. …”
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“…Pathology revealed pT3N1Mx Metastatic Papillary Thyroid Cancer (conventional type) involving the skeletal muscle and one out of six right cervical neck lymph nodes. The resection margins were negative for carcinoma. Post operatively the patient received radioactive iodine treatment and Levothyroxine was initiated. …”
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“…Pathology results were remarkable for invasive encapsulated follicular variant of papillary thyroid carcinoma with focal angioinvasion and tumor capsular invasion. The margins were negative for tumor. The parenchyma was consistent with lymphocytic thyroiditis. …”
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“…Pathology revealed a 1.2 cm papillary thyroid carcinoma, conventional type (confirmed by TTF-1 and thyroglobulin stains), arising within the thyroglossal duct cyst. Surgical margins were free of cancer, and there was no lymphovascular invasion. …”
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