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47981por Lazarus, Rajeka, Querton, Benedicte, Corbic Ramljak, Irena, Dewasthaly, Shailesh, Jaramillo, Juan Carlos, Dubischar, Katrin, Krammer, Michael, Weisova, Petronela, Hochreiter, Romana, Eder-Lingelbach, Susanne, Taucher, Christian, Finn, Adam“…The primary immunogenicity outcome was the immune response of a two-dose schedule of VLA2001 on day 43, in adults aged 30 years and older, versus two doses of ChAdOx1-S via superiority of geometric mean titres (GMTs) of neutralising antibodies (GMT ratio of >1 at a two-sided significance level of 5%) and non-inferiority of the seroconversion rate (non-inferiority margin of –10% for the lower limit of the 95% CI for the difference between groups). …”
Publicado 2022
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47982por Kanungo, Suman, Chatterjee, Pranab, Bavdekar, Ashish, Murhekar, Manoj, Babji, Sudhir, Garg, Richa, Samanta, Sandip, Nandy, Ranjan K, Kawade, Anand, Boopathi, Kangusamy, Kanagasabai, Kaliaperumal, Kamal, Vineet Kumar, Kumar, Velusamy Saravana, Gupta, Nivedita, Dutta, Shanta“…The seroresponse rates were compared between recipients of the four mixed vaccine regimens (consisting of various combinations of Rotavac and Rotasiil) with recipients of the single vaccine regimens (consisting of Rotavac or Rotasiil only for all three doses). The non-inferiority margin was set at 10%. Safety follow-ups were done for the duration of study participation. …”
Publicado 2022
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47983“…The probability of high disability increased from an OR of 1.42 (95% CI 1.33 – 1.52, p < 0.001) per marginal increase in the PHQ-4 scale before the pandemic, to an OR of 1.73 (95% CI 1.58 – 1.89, p < 0.001) during the pandemic. …”
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47984por Amuge, Pauline, Lugemwa, Abbas, Wynne, Ben, Mujuru, Hilda A, Violari, Avy, Kityo, Cissy M, Archary, Moherndran, Variava, Ebrahim, White, Ellen, Turner, Rebecca M, Shakeshaft, Clare, Ali, Shabinah, Nathoo, Kusum J, Atwine, Lorna, Liberty, Afaaf, Bbuye, Dickson, Kaudha, Elizabeth, Mngqibisa, Rosie, Mosala, Modehei, Mumbiro, Vivian, Nanduudu, Annet, Ankunda, Rogers, Maseko, Lindiwe, Kekitiinwa, Adeodata R, Giaquinto, Carlo, Rojo, Pablo, Gibb, Diana M, Turkova, Anna, Ford, Deborah“…METHODS: ODYSSEY is an open-label, randomised, non-inferiority trial (10% margin) comparing dolutegravir-based ART with standard of care and comprises two cohorts (children weighing ≥14 kg and <14 kg). …”
Publicado 2022
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47985por McGovern, Paul C, Wagenlehner, Florian, Gasink, Leanne, Moeck, Greg, McLeroth, Patrick L, Beth, Mary, Dane, Aaron, Henkel, Tim“…Patients were randomized 2:1 to FTB 2.5g IV q8h or MEM 1g IV q8h for 7 days or up to 14 days in patients with bacteremia. The non-inferiority margin was -15.0% and a pre-specified test for superiority for the primary endpoint was performed following confirmation of non-inferiority. …”
Publicado 2022
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47986por Holland, Thomas L, Cosgrove, Sara E, Doernberg, Sarah B, Pavlov, Oleksander, Titov, Ivan, Atanasov, Boyko, Gehr, Maziar Assadi, Engelhardt, Marc, Hamed, Kamal, Ionescu, Daniel, Jones, Mark, Sauley, Mikael, Smart, Jennifer, Seifert, Harald, Jenkins, Timothy C, Turner, Nicholas A, Fowler, Vance G“…Success required survival, no new SAB complications, symptom improvement, SAB clearance, and no receipt of other potentially effective antibiotics. The non-inferiority margin for the difference in success rates was -15% (BPR-DAP, 95% CI, 2-sided, lower bound). …”
Publicado 2022
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47987por Pierone, Gerald, Fusco, Jennifer S, Brunet, Laurence, Vannappagari, Vani, Sarkar, Supriya, Henegar, Cassidy, van Wyk, Jean A, Zolopa, Andrew, Fusco, Gregory P“…Univariate Poisson regression (incidence rates) and Cox proportional hazards marginal structural models were employed to assess confirmed virologic failure (2 viral loads [VLs] ≥200 copies/mL) or regimen discontinuation. …”
Publicado 2022
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47988por Louis, Edouard, Resche-Rigon, Matthieu, Laharie, David, Satsangi, Jack, Ding, Nik, Siegmund, Britta, D'Haens, Geert, Picon, Laurence, Bossuyt, Peter, Vuitton, Lucine, Irving, Peter, Viennot, Stephanie, Lamb, Christopher A, Pollok, Richard, Baert, Filip, Nachury, Maria, Fumery, Mathurin, Gilletta, Cyrielle, Almer, Sven, Ben-Horin, Shomron, Bouhnik, Yoram, Colombel, Jean-Frederic, Hertervig, Erik“…The coprimary endpoints were the relapse rate (superiority analysis) and time in remission over 2 years (non-inferiority analysis, non-inferiority margin 35 days). Analyses were done on an intention-to-treat basis. …”
Publicado 2023
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47989por Hara, Toshihiko, Kaneuji, Ayumi, Sonoda, Kazuhiko, Nakamura, Tetsuro, Fujii, Masanori, Takahashi, Eiji“…A 7-cm incision is made along the medial margin of the iliac crest. An anterior iliac crest osteotomy of 4.5 cm (length) × 1 cm (medial wedge-shaped) is performed. …”
Publicado 2022
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47990por Chen, Justin Z, Hoang, Holly L, Yaskina, Maryna, Kabbani, Dima, Doucette, Karen E, Smith, Stephanie W, Lau, Cecilia, Stewart, Jackson, Remtulla, Shahileen, Zurek, Karen, Schultz, Morgan, Koriyama-McKenzie, Hiromi, Cervera, Carlos“…We used a non-inferiority margin of 0·5. Analysis was by intention to treat. …”
Publicado 2023
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47991por Blanco Garcia, Oscar Roberto“…These will be used to for beam stabilization and could detect beam drift/jitter beyond the tolerable margin and undetected optics mismatch affecting the beam size measurements.…”
Publicado 2015
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47992por Ravasenga, Ivan“…The detection efficiency and the fake-hit rate of irradiated and non-irradiated chips were measured at beam test facilities demonstrating a sufficient operational margin even after 10$\times$ lifetime Non-Ionizing Energy Loss (NIEL) dose. …”
Publicado 2019
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47993por Xu, Ao“…Charmed hadron is a unique probe into nonperturbative QCD due to the fact that the charm quark mass is marginally larger than the QCD energy scale. This thesis performed a precise measurement of lifetimes of charmed baryon $\Omega{^0_c}$ and $\Xi{^0_c}$ and a search for the doubly charmed baryon $\Xi^+_{cc}$, using 𝑝𝑝 collision data collected by the LHCb experiment at the Large Hadron Collider. …”
Publicado 2023
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47994por Jain, Vinay, Saini, Divyalakshmi, Soren, D. C., Kumar, V. Anil, Vivek Kumar, P. R., Koya, P. K. M., Jaikrishan, G., Das, Birajalaxmi“…The frequency of γH2AX foci was observed to be 0.098 ± 0.042, 0.078 ± 0.037, 0.084 ± 0.042, 0.099 ± 0.058, 0.097 ± 0.06 and 0.114 ± 0.033 per cell in the age groups of ≤ 29, 30–34, 35–39, 40–44, 45–49 and ≥ 50 years, respectively (ANOVA, F(5,194) = 2.17, P = 0.059), which suggested marginal influence of age on the baseline of DSBs. …”
Publicado 2023
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47995“…Maximum acceptable risk (MAR), defined as the highest level of SAE risk that subjects would accept in return for a given improvement in efficacy (i.e., the increase in treatment risk that exactly offsets the hypothetical increase in treatment benefit), was calculated using preference weights (parameter marginal log odds ratios) that were estimated with conjoint analysis (random parameters logit models). …”
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47996“…Her antineutrophil cytoplasmic antibodies (ANCA) were reported as weakly atypical positive with marginally raised MPO of 9U/ml and negative PR3 levels. …”
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47997“…Under the dominant model, only in the Asian ethnic group showed a marginally and significantly increased risk of gastric cancer (overall: OR = 1.22, 95%CI = 0.90–1.67, I(2) = 56%; Asian: OR = 1.24, 95%CI = 1.00-1.54, I(2) = 0%, non-Asian: OR = 1.25, 95%CI = 0.38–4.09, I(2) = 89%). …”
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47998por Spijkerman, Renske, Roek, Marion AE, Vermulst, Ad, Lemmers, Lex, Huiberts, Annemarie, Engels, Rutger CME“…Furthermore, the intervention with normative feedback reduced weekly drinking only at 1 month after the intervention (n=575, beta = -.24, P = .008). There was also a marginally significant trend of the intervention without normative feedback on responsible drinking at the 3-month follow-up (n =575, beta = .40, P =.07) implying a small increase in moderate drinking at the 3-month follow-up. …”
Publicado 2010
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47999“…Sparse collagen layers are also interspersed between stromal layers of fat cells surrounding TEBs. At the margins, TEBs approach the outer collagen layer but do not penetrate it. …”
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48000“…Metrifonate A single dose of metrifonate 10 mg/kg reduced egg excretion (210 participants, one trial, at eight months), but was only marginally better than placebo at achieving cure at one month (RR 0.83, 95% CI 0.74 to 0.94, 142 participants, one trial). …”
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