“…OBJECTIVES: Several morphological risk factors for anterior cruciate ligament (ACL) injury have been identified,(1,6,12,13) including the size of the ACL.(5,8,12,15) A smaller ACL volume and diameter are associated with a greater risk of injury when comparing ACL-injured subjects to matched controls.(5,8,12,15) Although morphological risk factors as a group have been largely characterized as non-modifiable,(9,10) ACL surface and cross-sectional areas (CSA) have the potential for modifiability, especially during growth and development.(7,11) These ACL area measures have increased and the mechanical properties of the ACL have improved following exercise through periods of growth in animal models.(2,7,11,14) In humans, we are only aware of one study of ACL hypertrophy—a small study of elite weightlifters.(7)The main purpose of this study, therefore, was to determine whether the ACL can hypertrophy in response to mechanical loading by comparing bilateral differences in ACL CSA in athletes who habitually load one leg more than the other in training for their sport. …”
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“…For this subgroup analysis, participants were defined as being SARS-CoV-2 seropositive or seronegative prevaccination via anti-SARS-CoV-2 spike (S)1 or S2 IgG (cutoff of 15·0 arbitrary units [AU] per mL) or neutralising antibody titres (cutoff of ≥30%) and were matched for age and sex, via convenience sampling, in a 1:3:1:1 ratio (seropositive patients to seronegative patients to seropositive controls to seronegative controls). …”
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“…COVID-19 cases were compared with a cohort of all pediatric allogeneic HCT recipients without COVID-19 matched by the transplant center. Impact of hematopoietic cell transplant comorbidity index (HCT-CI), HCT indication, donor type, conditioning intensity, graft vs. host disease (GVHD) prophylaxis, and occurrence of acute and chronic GVHD on development of COVID-19 was examined using Cox proportional hazards model. …”
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“…We report here the results in CLL, NHL and HL patients in comparison to age- and gender-matched controls who were vaccinated at the same time period (January to May 2021). …”
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“…Conversely, ongoing immunosuppressive (IS)/chemotherapy treatment and a haploidentical source of graft were associated with lower responses to vaccination (respectively 62.5 vs 90.5%, p<10 (-3), and 69.4 vs 88.6% for patients with matched donors, p=0.02). In multivariate analysis (Fig.1) also including D0-V1 interval, donor source, current IS/chemotherapy treatment and TCD4 Ly count, only B cell aplasia remained statistically associated with lack of antibody response after two vaccine injections (OR 0.01, 95%CI [0.00 - 0.10], p <10 (-3)). …”
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“…These data serve as pre-clinical validation for an ongoing clinical trial utilizing related HLA-matched and haplo-identical SARS CoV-2 vCTLs for the treatment of patients with mild and moderate SARS-CoV-2 disease (IND #27260, NCT# 04896606). …”
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“…Results Eighty-five participants received their first dose of BNT162b2 from 18 May 2021 to 7 June 2021 with a second dose 21 days later: 72 lymphoma patients (WM and FL) and 13 age-matched healthy volunteers (controls). Of 37 with WM [19 (51.3%) female, median 71 years (IQR 63-74)] 9 were treatment naïve (WMN), 15 had received rituximab-chemotherapy (WMT), and 13 were currently treated with a Bruton Tyrosine Kinase inhibitor (BTKi): 5 ibrutinib, 8 zanubrutinib (WMB). …”
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“…Patient with available matched serological and vaccination status data at time of data cut-off (09 JUL 2021) were included. …”
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“…We recruited 10 SGM cancer patients and 8 heterosexual, cisgender (H/C) patient matches, and their self-identified informal cancer caregivers (n=36, dyad total n=18). …”
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“…Despite developments, psychiatry heavily relies on patients’ interviews and self-reporting to match the diagnostic criteria of the ICD or DSM and is still handicapped by the lack of objective measurements for diagnosis and management. …”
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“…AUTHORS' CONCLUSIONS: Although effectiveness gaps remain, current programmatic interests are not matched by a rigorous evidence base demonstrating how to appropriately design and implement social protection interventions. …”
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“…Furthermore, the measured pulse shapes for different configurations of cancellation match very well with the simulation of the ASIC performed by the team of Barcelona. …”
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“…Indices of skeletal dynamics trended toward age- and sex-matched norms in the TransCon/TransCon PTH group. …”
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“…Specifically, a broad systems approach is needed to address the full spectrum of issues; accessibility and effectiveness are improved through collaboration across stakeholders; a range of system supports are needed; need for services should be grounded in self-determination, holistic cultural practices, choice, and partnership; attention to diversity and social-structural disadvantages are crucial to equitable system design; systematic screening and assessment is needed to match people to appropriate treatment services in a stepped service framework; and, last, individualized treatment planning must include the right mix of evidence-informed interventions. …”
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“…Further studies by our group are underway to assess hemostatic balance in donor CP, to estimate associations with outcomes by comparing patients who received CP with a matched control cohort of COVID-19 patients who did not receive CP, and to evaluate efficacy of CP in a randomized, placebo-controlled clinical trial. …”
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“…DATA COLLECTION AND ANALYSIS: Two authors independently assessed studies for inclusion and risk of bias, and conducted data extraction. Data were matched to check for accuracy. Quality of evidence was assessed using the GRADE approach. …”
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“…Assignment to these conditions could be either experimental or quasi‐experimental, but quasi‐experimental studies were required to use either matched comparison groups or multivariate analysis methods to control for confounding factors. …”
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“…The comparator group for immunogenicity assessments included 113 participants from the initial pediatric study (NCT04816643) who received 3 original BNT162b2 10 μg doses and who were matched by age and SARS-CoV-2 infection status. RESULTS: Of the 113 children who received bivalent BNT162b2, 50% were female, 58% White, and 58% SARS-CoV-2 positive at baseline. …”
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“…A study identification code with the format “SAINT-##” (##: from 01 to 24) will be generated using a sequence of random numbers so that the randomization number does not match the subject identifier. The sequence and code used will be kept in an encrypted file accessible only to the trial statistician. …”
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“…Methods: We enrolled 149 participants, including 129 with lymphoma and 20 age-matched controls, who received a complete COVID-19 vaccination series to assess how B- and T-cell vaccine responses vary among clinically relevant subgroups and over time. …”
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