Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers

por Su, Lu, Dalby, Kellie S., Luehmann, Hannah, Elkassih, Sussana A., Cho, Sangho, He, Xun, Detering, Lisa, Lin, Yen-Nan, Kang, Nari, Moore, Dennis A., Laforest, Richard, Sun, Guorong, Liu, Yongjian, Wooley, Karen L.
Publicado 2023

Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrulli...

por Lv, Changjun, Sun, Minghui, Guo, Yilei, Xia, Wenxin, Qiao, Simiao, Tao, Yu, Fang, Yulai, Zhang, Qin, Zhu, Yanrong, Yalikun, Yusufu, Xia, Yufeng, Wei, Zhifeng, Dai, Yue
Publicado 2023

AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells

por Bing, Shaowei, Xiang, Senfeng, Xia, Zhimei, Wang, Yilong, Guan, Zhonghai, Che, Jinxin, Xu, Aixiao, Dong, Xiaowu, Cao, Ji, Yang, Bo, Wang, Jinhu, He, Qiaojun, Ying, Meidan
Publicado 2023

Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis

por Chan, Yau-tuen, Tan, Hor-yue, Lu, Yuanjun, Zhang, Cheng, Cheng, Chien-shan, Wu, Junyu, Wang, Ning, Feng, Yibin
Publicado 2023

The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation

por Zhu, Yiwei, Lei, Lin, Wang, Xinghui, Chen, Linfang, Li, Wei, Li, Jinxia, Zhao, Chenchen, Du, Xiliang, Song, Yuxiang, Gao, Wenwen, Liu, Guowen, Li, Xinwei
Publicado 2023

On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition

por Liu, Xiaoqing, Liang, Shuang, Sang, Xiao, Chang, Lili, Fu, Shunli, Yang, Han, Yang, Huizhen, Liu, Yongjun, Zhang, Na
Publicado 2023

A novel biological sources consistency evaluation method reveals high level of biodiversity within wild natural medicine: A case study of Amynthas earthworms as “Guang Dilong”

por Xing, Zhimei, Gao, Han, Wang, Dan, Shang, Ye, Tuliebieke, Tenukeguli, Jiang, Jibao, Li, Chunxiao, Wang, Hong, Li, Zhenguo, Jia, Lifu, Wu, Yongsheng, Wang, Dandan, Yang, Wenzhi, Chang, Yanxu, Zhang, Xiaoying, Xu, Liuwei, Jiang, Chao, Huang, Luqi, Tian, Xiaoxuan
Publicado 2023

TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2

por Lv, Xiaoxi, Liu, Shanshan, Liu, Chang, Li, Yunxuan, Zhang, Tingting, Qi, Jie, Li, Ke, Hua, Fang, Cui, Bing, Zhang, Xiaowei, Liu, Yuxin, Yu, Jiaojiao, Yu, Jinmei, Li, Li, Li, Xia, Yao, Zhigang, Huang, Bo
Publicado 2023

Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis

por Han, Zhihui, Gao, Xiang, Wang, Yuanjie, Cheng, Shuning, Zhong, Xiaoyan, Xu, Yong, Zhou, Xiaozhong, Zhang, Zengli, Liu, Zhuang, Cheng, Liang
Publicado 2023

Supramolecular approaches for insulin stabilization without prolonged duration of action

por Meudom, Rolande, Zhang, Yanxian, VandenBerg, Michael A., Zou, Lei, Zhang, Yi Wolf, Webber, Matthew J., Chou, Danny Hung-Chieh
Publicado 2023

Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe

por Zhang, Hongjuan, Chen, Ying, Zhang, Yu, Qiao, Luyao, Chi, Xiangyin, Han, Yanxing, Lin, Yuan, Si, Shuyi, Jiang, Jiandong
Publicado 2023

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

por Knez, Damijan, Diez-Iriepa, Daniel, Chioua, Mourad, Gottinger, Andrea, Denic, Milica, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Meden, Anže, Pišlar, Anja, Kos, Janko, Žakelj, Simon, Stojan, Jure, Sałat, Kinga, Serrano, Julia, Fernández, Ana Patricia, Sánchez-García, Aitana, Martínez-Murillo, Ricardo, Binda, Claudia, López-Muñoz, Francisco, Gobec, Stanislav, Marco-Contelles, José
Publicado 2023

Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing

por Neupane, Yub Raj, Handral, Harish K., Alkaff, Syed Abdullah, Chng, Wei Heng, Venkatesan, Gopalakrishnan, Huang, Chenyuan, Lee, Choon Keong, Wang, Jiong-Wei, Sriram, Gopu, Dienzo, Rhonnie Austria, Lu, Wen Feng, Ali, Yusuf, Czarny, Bertrand, Pastorin, Giorgia
Publicado 2023

The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

por Wu, Kan Xing, Yogarajah, Thinesshwary, Loe, Marcus Wing Choy, Kaur, Parveen, Lee, Regina Ching Hua, Mok, Chee Keng, Wong, Yi Hao, Phuektes, Patchara, Yeo, Li Sze, Chow, Vincent T.K., Tan, Yong Wah, Chu, Justin Jang Hann
Publicado 2023

Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression

por Tang, Chuanfeng, Wang, Qiaona, Shen, Jingyan, Wang, Congying, Ding, Hong, Wen, Shiyu, Yang, Fan, Jiao, Ruiqing, Wu, Xingxin, Li, Jianmei, Kong, Lingdong
Publicado 2023

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

por Hu, Chuan, Song, Yujun, Zhang, Yiwei, He, Siqin, Liu, Xueying, Yang, Xiaotong, Gong, Tao, Huang, Yuan, Gao, Huile
Publicado 2023

HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a broad-spectrum SARS-CoV-2 inhibitor via intranasal administration

por Lu, Ying, Shen, Fan, He, Wen-Qiang, Li, An-Qi, Li, Ming-Hua, Feng, Xiao-Li, Zheng, Yong-Tang, Pang, Wei
Publicado 2023

Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations

por Shi, Chen, Zhang, Cong, Fu, Zhiwen, Liu, Jinmei, Zhou, Yuanfeng, Cheng, Bao, Wang, Cong, Li, Shijun, Zhang, Yu
Publicado 2023

Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations

por Li, Pengyun, Jia, Changkai, Fan, Zhiya, Hu, Xiaotong, Zhang, Wenjuan, Liu, Ke, Sun, Shiyang, Guo, Haoxin, Yang, Ning, Zhu, Maoxiang, Zhuang, Xiaomei, Xiao, Junhai, Zheng, Zhibing, Li, Song
Publicado 2023

Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A(2A/2B) receptors in tolerogenic dendritic cells

por Shi, Gaona, Zhou, Yu, Liu, Wenshuai, Chen, Chengjuan, Wei, Yazi, Yan, Xinlong, Wu, Lei, Wang, Weiwei, Sun, Lan, Zhang, Tiantai
Publicado 2023