ETCM v2.0: An update with comprehensive resource and rich annotations for traditional Chinese medicine

por Zhang, Yanqiong, Li, Xin, Shi, Yulong, Chen, Tong, Xu, Zhijian, Wang, Ping, Yu, Meng, Chen, Wenjia, Li, Bing, Jing, Zhiwei, Jiang, Hong, Fu, Lu, Gao, Wenjing, Jiang, Yanhua, Du, Xia, Gong, Zipeng, Zhu, Weiliang, Yang, Hongjun, Xu, Haiyu
Publicado 2023

Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis

por Yu, Qian, Li, Chang, Niu, Qinghui, Wang, Jigang, Che, Zhaodi, Lei, Ke, Ren, He, Ma, Boyi, Ren, Yixing, Luo, Pingping, Fan, Zhuming, Zhang, Huan, Liu, Zhaohui, Tipoe, George L., Xiao, Jia
Publicado 2023

Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA

por Zhang, Wenxin, Pan, Xiaohui, Xu, Yanjun, Guo, Hongjie, Zheng, Mingming, Chen, Xi, Wu, Honghai, Luan, Fengming, He, Qiaojun, Ding, Ling, Yang, Bo
Publicado 2023

Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

por Peng, Kezheng, Zeng, Chenye, Gao, Yuqi, Liu, Binliang, Li, Liyuan, Xu, Kang, Yin, Yuemiao, Qiu, Ying, Zhang, Mingkui, Ma, Fei, Wang, Zhao
Publicado 2023

Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

por Wang, Xiaomin, Xu, Jun, Sun, Yiming, Cao, Siyuwei, Zeng, Hanlin, Jin, Nan, Shou, Matthew, Tang, Shuai, Chen, Yi, Huang, Min
Publicado 2023

Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors

por Ma, Lijuan, Li, Boyi, Ma, Jinchen, Wu, Chunyuan, Li, Nan, Zhou, Kailin, Yan, Yun, Li, Mingshuang, Hu, Xiaoyan, Yan, Hao, Wang, Qi, Zheng, Yanfei, Wu, Zhisheng
Publicado 2023

MF-SuP-pK(a): Multi-fidelity modeling with subgraph pooling mechanism for pK(a) prediction

por Wu, Jialu, Wan, Yue, Wu, Zhenxing, Zhang, Shengyu, Cao, Dongsheng, Hsieh, Chang-Yu, Hou, Tingjun
Publicado 2023

A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression

por Zhou, Yi, Miao, Yingling, Huang, Qiudi, Shi, Wenwen, Xie, Jiacui, Lin, Jiachang, Huang, Pei, Yue, Chengfeng, Qin, Yuan, Yu, Xiyong, Wang, He, Qin, Linghao, Chen, Jianhai
Publicado 2023

GPRC5B protects osteoarthritis by regulation of autophagy signaling

por He, Liang, Xu, Ziwei, Niu, Xin, Li, Rong, Wang, Fanhua, You, Yu, Gao, Jingduo, Zhao, Lei, Shah, Karan M., Fan, Jian, Liu, Mingyao, Luo, Jian
Publicado 2023

Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and rep...

por Tong, Fan, Hu, Haili, Xu, Yanyan, Zhou, Yang, Xie, Rou, Lei, Ting, Du, Yufan, Yang, Wenqin, He, Siqin, Huang, Yuan, Gong, Tao, Gao, Huile
Publicado 2023

Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

por Liu, Haowei, Huang, Qiuming, Fan, Yunqi, Li, Bo, Liu, Xuemei, Hu, Changhua
Publicado 2023

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

por Yue, Xin, Liu, Tingyu, Wang, Xuecen, Wu, Weijian, Wen, Gesi, Yi, Yang, Wu, Jiaxin, Wang, Ziyang, Zhan, Weixiang, Wu, Ruirui, Meng, Yuan, Cao, Zhirui, Le, Liyuan, Qiu, Wenyan, Zhang, Xiaoyue, Li, Zhenyu, Chen, Yong, Wan, Guohui, Bu, Xianzhang, Peng, Zhenwei, Liu, Ran-yi
Publicado 2023

Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae

por Li, Haibin, Sun, Lang, Qiao, Han, Sun, Zongti, Wang, Penghe, Xie, Chunyang, Hu, Xinxin, Nie, Tongying, Yang, Xinyi, Li, Guoqing, Zhang, Youwen, Wang, Xiukun, Li, Zhuorong, Jiang, Jiandong, Li, Congran, You, Xuefu
Publicado 2023

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

por Tang, Xin, Wang, Chuanxi, Wang, Lei, Ren, Feifei, Kuang, Runqiao, Li, Zhenhua, Han, Xue, Chen, Yiming, Chen, Guodong, Wu, Xiuqing, Liu, Jie, Yang, Hengwen, Liu, Xingzhong, Wang, Chen, Gao, Hao, Yin, Zhinan
Publicado 2023

Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation

por Yang, Junjie, Pan, Yue, Zeng, Xiaoshan, Liu, Shuwen, Chen, Zhipeng, Cheng, Kui
Publicado 2023

Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1- and G6PC-mediated gluconeogenesis

por Yang, Hanyu, Su, Mengxiang, Liu, Ming, Sheng, Yun, Zhu, Liang, Yang, Lu, Mu, Ruijing, Zou, Jianjun, Liu, Xiaodong, Liu, Li
Publicado 2023

Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier

por Nguyen Cao, Thuy Giang, Kang, Ji Hee, Kang, Su Jin, Truong Hoang, Quan, Kang, Han Chang, Rhee, Won Jong, Zhang, Yu Shrike, Ko, Young Tag, Shim, Min Suk
Publicado 2023

Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy

por Hu, Chen, Shen, Lijuan, Zou, Fengming, Wu, Yun, Wang, Beilei, Wang, Aoli, Wu, Chao, Wang, Li, Liu, Jing, Wang, Wenchao, Liu, Qingsong
Publicado 2023

Functional annotation map of natural compounds in traditional Chinese medicines library: TCMs with myocardial protection as a case

por Xing, Xudong, Sun, Mengru, Guo, Zifan, Zhao, Yongjuan, Cai, Yuru, Zhou, Ping, Wang, Huiying, Gao, Wen, Li, Ping, Yang, Hua
Publicado 2023

Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

por Ouyang, Xiaosen, Wani, Willayat Y., Benavides, Gloria A., Redmann, Matthew J., Vo, Hai, van Groen, Thomas, Darley-Usmar, Victor M., Zhang, Jianhua
Publicado 2023