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73001por Attaluri, Sahithi, Jaimes Gonzalez, Jenny, Kirmani, Maha, Vogel, Andrew D., Upadhya, Raghavendra, Kodali, Maheedhar, Madhu, Leelavathi N., Rao, Shama, Shuai, Bing, Babu, Roshni S., Huard, Charles, Shetty, Ashok K.“…EVs also came in contact with the plasma membranes of astrocytic processes and the soma of oligodendrocytes in white matter regions. Evaluation of CD63/CD81 expression with the neuronal marker confirmed that PKH26 + particles found within neurons were IN administered hiPSC-NSC-EVs. …”
Publicado 2023
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73002por Shao, Mingbo, Wang, Can, Zhou, Lingbo, Peng, Fangli, Zhang, Guobing, Gao, Jie, Chen, Siyu, Zhao, Qiang“…Compared to SW treatment, the 2W1S treatment increased the organic matter, total N, total P, total K, gram-negative bacteria phospholipid fatty acids (PLFAs), and gram-positive bacteria PLFAs contents and catalase, polyphenol oxidase, and urease activities by 20.86%-25.67%, 34.33%-70.05%, 23.98%-33.83%, 44.12%-81.86%, 74.87%-194.32%, 81.59–136.59%, 91.44%-114.07%, 85.35%-146.91%, and 36.32%-63.94%, respectively. …”
Publicado 2023
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73003por Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng, Lanning, Christine L., Lee, Anita Y.H., Li, Li, Nair, Anilkumar G., O’Neill, Edward A., Stoch, S. Aubrey, Thaisrivongs, David A., Tucker, Thomas J., Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P., Volckaert, Bram, Wolford, Dennis G., Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J., Walji, Abbas M., Wood, Harold B.“…METHODS: Novel mRNA display screening technology was used to identify lead chemical matter, which was then optimized by applying structure-based drug design enabled by novel synthetic chemistry to identify macrocyclic peptide (MK-0616) with exquisite potency and selectivity for PCSK9. …”
Publicado 2023
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73004por Yu, Xiaojun, Hong, Weiping, Ye, Minting, Lai, Mingyao, Shi, Changzheng, Li, Linzhen, Ye, Kunlin, Xu, Jiali, Ai, Ruyu, Shan, Changguo, Cai, Linbo, Luo, Liangping“…Relative minimum ADC (rADC(min)), mean (rADC(mean)), maximum (rADC(max)), and rADC(max-min) (rADC(dif)) were obtained by standardization of the contralateral white matter. Maximum cerebral blood flow (CBF(max)) was obtained according to the ASL-CBF map. …”
Publicado 2023
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73005por Cardozo, Jussara Câmara, Barbosa Segundo, Inalmar D., Galvão, Edney R. V. P., da Silva, Djalma R., dos Santos, Elisama V., Martínez-Huitle, Carlos A.“…COD and color abatement results clearly showed that different organic matter/color removal efficiencies were achieved, depending on the j used. …”
Publicado 2023
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73006por Iwakura, Hiroshi, Takagi, Tomoyuki, Inaba, Hidefumi, Doi, Asako, Ueda, Yoko, Uraki, Shinsuke, Takeshima, Ken, Furukawa, Yasushi, Ishibashi, Tatsuya, Morita, Shuhei, Matsuno, Shohei, Nishi, Masahiro, Furuta, Hiroto, Matsuoka, Taka-aki, Akamizu, Takashi“…BACKGROUND: The higher prevalence of thyroid dysfunction in type 1 diabetes patients has been well established, whereas it is a matter of debate whether that is also observed in type 2 diabetes patients. …”
Publicado 2023
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73007por Čerina, Dora, Krpina, Kristina, Jakopović, Marko, Dedić Plavetić, Natalija, Seiwerth, Fran, Tomić, Snježana, Radić, Jasna, Belac Lovasić, Ingrid, Canjko, Ivana, Boban, Marijo, Samaržija, Miroslav, Vrdoljak, Eduard“…SIMPLE SUMMARY: Precision medicine has reached its current peak in non-small cell lung cancer (NSCLC), with a constantly growing number of predictive biomarkers and new targeted therapies that when applied, significantly affect and change outcomes. Hence, the matter in question is how we might optimally detect and implement them in the treatment of our patients in everyday clinical practice. …”
Publicado 2023
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73008por Lehrieder, Dominik, Müller, Hans-Peter, Kassubek, Jan, Hecht, Nils, Thomalla, Götz, Michalski, Dominik, Gattringer, Thomas, Wartenberg, Katja E., Schultze-Amberger, Jörg, Huttner, Hagen, Kuramatsu, Joji B., Wunderlich, Silke, Steiner, Hans-Herbert, Weissenborn, Karin, Heck, Suzette, Günther, Albrecht, Schneider, Hauke, Poli, Sven, Dohmen, Christian, Woitzik, Johannes, Jüttler, Eric, Neugebauer, Hermann“…INTRODUCTION: In malignant cerebral infarction decompressive hemicraniectomy has demonstrated beneficial effects, but the optimum size of hemicraniectomy is still a matter of debate. Some surgeons prefer a large-sized hemicraniectomy with a diameter of more than 14 cm (HC > 14). …”
Publicado 2023
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73009por Brancati, Giulio Emilio, Nunes, Abraham, Scott, Katie, O’Donovan, Claire, Cervantes, Pablo, Grof, Paul, Alda, Martin“…BACKGROUND: The distinction between bipolar I and bipolar II disorder and its treatment implications have been a matter of ongoing debate. The aim of this study was to examine differences between patients with bipolar I and II disorders with particular emphasis on the early phases of the disorders. …”
Publicado 2023
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73010por Nielssen, Ingrid, Ahmed, Sadia, Zelinsky, Sandra, Dompe, Brian, Fairie, Paul, Santana, Maria J.“…INTRODUCTION: Patient engagement in patient‐oriented research (POR) is described as patients collaborating as active and equal research team members (patient research partners [PRPs]) on the health research projects and activities that matter to them. The Canadian Institutes of Health Research (CIHR), Canada's federal funding agency for health research, asks that patients be included as partners early, often and at as many stages of the health research process as possible. …”
Publicado 2023
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73011“…CTA had no significant effects on soil nutrients and organic matter. CTA decreased the fungal number and alpha-diversity of fungi and bacteria, and both the fungal and bacterial communities were significantly different from the other two. …”
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73012por Zhou, Xinhong, Zhang, Huaidan, Li, Shiyi, Jiang, Yilong, Kang, Lijuan, Deng, Jicheng, Yang, Chuanpeng, Zhao, Xin, Zhao, Jingjing, Jiang, Li, Chen, Xianxin“…Moreover, supplementing 3% FCSF enhanced the utilization of total phosphorus, dry matter, crude protein, and crude ash in the feed by broilers (p < 0.05). …”
Publicado 2023
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73013por Bargiela, Rafael, Korzhenkov, Aleksei A., McIntosh, Owen A., Toshchakov, Stepan V., Yakimov, Mikhail M., Golyshin, Peter N., Golyshina, Olga V.“…Moreover, known great diversity of uncultured Thermoplasmatales represents microbial dark matter and underlines the necessity of efforts in cultivation and study of these archaea. …”
Publicado 2023
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73014por Reyes, Diana C., Meredith, Jennifer, Puro, Leah, Berry, Katherine, Kersbergen, Richard, Soder, Kathy J., Quigley, Charlotte, Donihue, Michael, Cox, Dorn, Price, Nichole N., Brito, Andre F.“…Twenty-two organically certified Holstein and Jersey cows averaging 29 ± 6.8 kg of milk/d and 150 ± 69 days in milk, were blocked and randomly assigned to a control diet without C. crispus (0CC), or with 6% [dry matter (DM) basis] C. crispus (6CC). Samples were collected on the last week of the 2-wk covariate period, and wk 3, 5, 8, and 10 after initiation of treatments for a total of 12 weeks. …”
Publicado 2023
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73015por Wang, Fang, Cao, Huifen, Xia, Qiu, Liu, Ziheng, Wang, Ming, Gao, Fan, Xu, Dongyang, Deng, Bolin, Diao, Yong, Kapranov, Philipp“…Our findings demonstrate that most of true A-to-I editing sites in a human cancer cell line are located in the non-coding transcripts, the so-called RNA 'dark matter'. On the other hand, many ADAR editing events occurring in exons of human protein-coding mRNAs, including those that can recode the transcriptome, represent false positives and need to be interpreted with caution. …”
Publicado 2023
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73016por Hamm, Rebecca F., Moniz, Michelle H., Wahid, Inaya, Breman, Rachel Blankstein, Callaghan-Koru, Jennifer A.“…A purposeful, yet broad sample of researchers with relevant subject matter knowledge was identified through searches of published articles and grant databases. …”
Publicado 2023
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73017por Mutedzi, Barbara, Nkhoma, Kennedy, Langhaug, Lisa, Hunt, Jennifer, Harding, Richard“…Through the published protocol, the literature review and the results of this study, it has been noted that there is an urgent need to carry out a full trial in this subject matter, not only as a contribution to the currently sparse literature in this regard, but for the enormous potential public health benefit in supporting and saving lives in many more under-resourced and under-supported countries. …”
Publicado 2023
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73018por Lundy-Woolfolk, Erika L, Genther-Schroeder, Olivia N, Branine, Mark, Hansen, Stephanie L“…Forty-two steers (417 ± 3.99 kg; n = 6/pen) were housed in pens with bunks designed to measure individual dry matter intake (DMI) and fed one of two diets containing either 0 (CON; n = 18) or 90 mg Zn/kg from a Zn-amino acid complex (Zn-AA; n = 18; AvailaZn; Zinpro) for 109 d. …”
Publicado 2023
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73019por Lin, Weixian, Wang, Jiaren, Ge, Jing, Zhou, Rui, Hu, Yahui, Xiao, Lushan, Peng, Quanzhou, Zheng, Zemao“…Consequently, there are still few studies on lung adenocarcinoma (LUAD)-related cuproptosis, and we aimed to deepen in this matter. In this study, data from 503 patients with lung cancer from the TCGA-LUAD cohort data collection and 11 LUAD single-cells from GSE131907 as well as from 10 genes associated with cuproptosis were analyzed. …”
Publicado 2023
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73020por Díez-Cirarda, Maria, Yus-Fuertes, Miguel, Sanchez-Sanchez, Rafael, Gonzalez-Rosa, Javier J., Gonzalez-Escamilla, Gabriel, Gil-Martínez, Lidia, Delgado-Alonso, Cristina, Gil-Moreno, Maria Jose, Valles-Salgado, Maria, Cano-Cano, Fatima, Ojeda-Hernandez, Denise, Gomez-Ruiz, Natividad, Oliver-Mas, Silvia, Benito-Martín, María Soledad, Jorquera, Manuela, de la Fuente, Sarah, Polidura, Carmen, Selma-Calvo, Belén, Arrazola, Juan, Matias-Guiu, Jorge, Gomez-Pinedo, Ulises, Matias-Guiu, Jordi A.“…FINDINGS: In vivo analyses revealed that hippocampal grey matter atrophy is accompanied by altered microstructural integrity, hypoperfusion, and functional connectivity changes in PCS patients. …”
Publicado 2023
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