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73121Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadicspor Whitwell, Jennifer L., Weigand, Stephen D., Boeve, Bradley F., Senjem, Matthew L., Gunter, Jeffrey L., DeJesus-Hernandez, Mariely, Rutherford, Nicola J., Baker, Matthew, Knopman, David S., Wszolek, Zbigniew K., Parisi, Joseph E., Dickson, Dennis W., Petersen, Ronald C., Rademakers, Rosa, Jack, Clifford R., Josephs, Keith A.“…Voxel-based morphometry was used to assess and compare patterns of grey matter atrophy. Atlas-based parcellation was performed utilizing the automated anatomical labelling atlas and Statistical Parametric Mapping software to compute volumes of 37 regions of interest. …”
Publicado 2012
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73122“…The functional annotation of genomes, construction of molecular networks and novel drug target identification, are important challenges that need to be addressed as a matter of great urgency(1-4). Multiple complementary 'omics' approaches have provided clues as to the genetic risk factors and pathogenic mechanisms underlying numerous neurodegenerative diseases, but most findings still require functional validation(5). …”
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73123por Merlo, Domenico F, Filiberti, Rosangela, Kobernus, Michael, Bartonova, Alena, Gamulin, Marija, Ferencic, Zeljko, Dusinska, Maria, Fucic, Aleksandra“…The complexity of the interactions between cells, genes and the environment, i.e. the resonance of the living matter with the environment, can be synthesized by systems biology. …”
Publicado 2012
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73124por Hesterberg, Thomas W., Long, Christopher M., Bunn, William B., Lapin, Charles A., McClellan, Roger O., Valberg, Peter A.“…The changed particulate matter (PM) emissions in “New Technology Diesel Exhaust (NTDE)” from today's modern low-emission, advanced-technology on-road heavy-duty diesel engines now resemble the PM emissions in contemporary gasoline engine exhaust (GEE) and compressed natural gas engine exhaust more than those in the “traditional diesel exhaust” (TDE) characteristic of older diesel engines. …”
Publicado 2012
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73125“…When purified and added extrinsically, the PlyC holoenzyme lyses group A streptococci (GAS) as well as other streptococcal groups in a matter of seconds and furthermore has been validated in vivo against GAS(7). …”
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73126por Fuchigami, Takeshi, Takano, Akihiro, Gulyás, Balázs, Jia, Zhisheng, Finnema, Sjoerd J, Andersson, Jan D, Nakao, Ryuji, Magata, Yasuhiro, Haratake, Mamoru, Nakayama, Morio, Halldin, Christer“…In the ARG experiments, [(11) C]N-methyl-SSR504734 showed specific binding in the white matter and pons. In the initial PET experiments in a cynomolgus monkey, [(11) C]N-methyl-SSR504734 showed high brain uptake and consistent distribution with previously reported GlyT1 expression in vivo (thalamus, brainstem > cerebellum > cortical regions). …”
Publicado 2012
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73127por Lee, Soo-Young“…Although systematic epidemiologic studies have not reported on the matter, recently, plant foods related allergy has increased in Korean children. …”
Publicado 2013
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73128por Dadvand, Payam, Parker, Jennifer, Bell, Michelle L., Bonzini, Matteo, Brauer, Michael, Darrow, Lyndsey A., Gehring, Ulrike, Glinianaia, Svetlana V., Gouveia, Nelson, Ha, Eun-hee, Leem, Jong Han, van den Hooven, Edith H., Jalaludin, Bin, Jesdale, Bill M., Lepeule, Johanna, Morello-Frosch, Rachel, Morgan, Geoffrey G., Pesatori, Angela Cecilia, Pierik, Frank H., Pless-Mulloli, Tanja, Rich, David Q., Sathyanarayana, Sheela, Seo, Juhee, Slama, Rémy, Strickland, Matthew, Tamburic, Lillian, Wartenberg, Daniel, Nieuwenhuijsen, Mark J., Woodruff, Tracey J.“…Methods: Using a common analytical protocol, International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO) centers generated effect estimates for term LBW and continuous birth weight associated with PM(10) and PM(2.5) (particulate matter ≤ 10 and 2.5 µm). We used meta-analysis to combine the estimates of effect across centers (~ 3 million births) and used meta-regression to evaluate the influence of center characteristics and exposure assessment methods on between-center heterogeneity in reported effect estimates. …”
Publicado 2013
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73129por Adar, Sara D., Sheppard, Lianne, Vedal, Sverre, Polak, Joseph F., Sampson, Paul D., Diez Roux, Ana V., Budoff, Matthew, Jacobs, David R., Barr, R. Graham, Watson, Karol, Kaufman, Joel D.“…BACKGROUND: Fine particulate matter (PM(2.5)) has been linked to cardiovascular disease, possibly via accelerated atherosclerosis. …”
Publicado 2013
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73130por Margevicius, Kristen, Brown, Mac, Castro, Lauren, Daniel, William B., Generous, Eric N., Taylor-McCabe, Kirsten, Deshpande, Alina“…Information regarding surveillance systems and data streams has been (and continues to be) systematically culled from websites, peer-reviewed literature, government documents, and subject-matter expert consultations. METHODS: A relational database has been developed and refined to allow for detailed analyses of data streams and surveillance systems. …”
Publicado 2013
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73131“…The surgical treatment in severe forms of OI must be adapted to each case. No matter the surgical technique used, well known or innovative, it is convenient if it restores the ability to walk of a youngster who has been forced to use a wheelchair for almost 20 years and who has suffered dozens of unsuccessful surgeries. …”
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73132por Kutlubaev, Mansur A., Shenkin, Susan D., Farrall, Andrew J., Duncan, Fiona H., Lewis, Susan J., Greig, Carolyn A., Dennis, Martin S., Wardlaw, Joanna M., MacLullich, Alasdair M.J., Mead, Gillian E.“…It is unclear whether chronic brain changes [cerebral atrophy and white matter lesions (WML)], stroke lesion location or certain clinical features are related to its development. …”
Publicado 2013
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73133por Przylipiak, Andrzej Feliks, Galicka, Elżbieta, Donejko, Magdalena, Niczyporuk, Marek, Przylipiak, Jerzy“…There is not much literature addressing the subject matter of pre- and post-surgery blood parameters, although this information is rather interesting. …”
Publicado 2013
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73134por Gehring, Ulrike, Gruzieva, Olena, Agius, Raymond M., Beelen, Rob, Custovic, Adnan, Cyrys, Josef, Eeftens, Marloes, Flexeder, Claudia, Fuertes, Elaine, Heinrich, Joachim, Hoffmann, Barbara, de Jongste, Johan C., Kerkhof, Marjan, Klümper, Claudia, Korek, Michal, Mölter, Anna, Schultz, Erica S., Simpson, Angela, Sugiri, Dorothea, Svartengren, Magnus, von Berg, Andrea, Wijga, Alet H., Pershagen, Göran, Brunekreef, Bert“…Annual average exposure to air pollution [nitrogen oxides (NO(2), NO(x)), mass concentrations of particulate matter with diameters < 2.5, < 10, and 2.5–10 μm (PM(2.5), PM(10), and PM(coarse)), and PM(2.5) absorbance] at the birth address and current address was estimated by land-use regression models. …”
Publicado 2013
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73135por Hammami, Muhammad M, Al-Gaai, Eman A, Al-Jawarneh, Yussuf, Amer, Hala, Hammami, Muhammad B, Eissa, Abdullah, Qadire, Mohammad Al“…BACKGROUND: Although informed consent is an integral part of clinical practice, its current doctrine remains mostly a matter of law and mainstream ethics rather than empirical research. …”
Publicado 2014
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73136“…The anterior transthoracic approaches and lateral/posterolateral approaches are all essentially performed from one side; thus, the compressive lesion and the dura matter on the other side of the spinal canal are not clearly visualized, predisposing the procedure to incomplete decompression or inadvertent cord manipulation. …”
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73137por Zhang, Jinming, Fang, Shona C, Mittleman, Murray A, Christiani, David C, Cavallari, Jennifer M“…SHS exposure was quantified using a personal fine particulate matter (PM(2.5)) monitor. Linear mixed effects regression models were used to examine within-person changes in inflammatory and HRV parameters across the 3 time periods. …”
Publicado 2013
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73138por Fleischer, Nancy L., Merialdi, Mario, van Donkelaar, Aaron, Vadillo-Ortega, Felipe, Martin, Randall V., Betran, Ana Pilar, Souza, João Paulo“…Background: Inhaling fine particles (particulate matter with diameter ≤ 2.5 μm; PM(2.5)) can induce oxidative stress and inflammation, and may contribute to onset of preterm labor and other adverse perinatal outcomes. …”
Publicado 2014
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73139“…Significantly, neutralizing TLR(4) function largely reduced neuronal apoptosis determined by NeuN immunoreactivity in ventral gray matter and increased percentage of double-label cells with cleaved caspase3, whereas LPS reversed these effects. …”
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73140por Barreras, A., Castro-Pérez, B. I., López-Soto, M. A., Torrentera, N. G., Montaño, M. F., Estrada-Angulo, A., Ríos, F. G., Dávila-Ramos, H., Plascencia, A., Zinn, R. A.“…Treatments were: i) control, no ionophore; ii) 30 mg/kg monensin sodium (RUM30); iii) 20 mg/kg lasalocid sodium (BOV20), and iv) 30 mg/kg lasalocid sodium (BOV30). Both dry matter intake (DMI) and climatic variables were measured daily and the temperature humidity index (THI) was estimated. …”
Publicado 2013
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