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74561Real-world evidence on siponimod treatment in patients with secondary progressive multiple sclerosispor Regner-Nelke, Liesa, Pawlitzki, Marc, Willison, Alice, Rolfes, Leoni, Oezalp, Sinem-Hilal, Nelke, Christopher, Kölsche, Tristan, Korsen, Melanie, Grothe, Matthias, Groppa, Sergiu, Luessi, Felix, Engel, Sinah, Nelles, Gereon, Bonmann, Eckhard, Roick, Holger, Friedrich, Anke, Knorn, Philipp, Landefeld, Harald, Biro, Zoltan, Ernst, Michael, Bayas, Antonios, Menacher, Martina, Akgün, Katja, Kleinschnitz, Christoph, Ruck, Tobias, Ziemssen, Tjalf, Pul, Refik, Meuth, Sven G.“…Radiological assessment showed a stable volume of white and grey matter, as well as a stable lesion count at 12 months follow-up. …”
Publicado 2022
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74562por Chiavi, Deborah, Haag, Christina, Chan, Andrew, Kamm, Christian Philipp, Sieber, Chloé, Stanikić, Mina, Rodgers, Stephanie, Pot, Caroline, Kesselring, Jürg, Salmen, Anke, Rapold, Irene, Calabrese, Pasquale, Manjaly, Zina-Mary, Gobbi, Claudio, Zecca, Chiara, Walther, Sebastian, Stegmayer, Katharina, Hoepner, Robert, Puhan, Milo, von Wyl, Viktor“…This observed heterogeneity in emotional tonality underlying the reported experiences of the first COVID-19–related lockdown is likely to reflect differences in emotional burden, individual circumstances, and ways of coping with the pandemic, which is in line with previous research on this matter. CONCLUSIONS: This study illustrates the timely and efficient applicability of an NLP pipeline and thereby serves as a precedent for applied researchers. …”
Publicado 2022
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74563por King, Ashley J., Daly, Luke, Rowe, James, Joy, Katherine H., Greenwood, Richard C., Devillepoix, Hadrien A. R., Suttle, Martin D., Chan, Queenie H. S., Russell, Sara S., Bates, Helena C., Bryson, James F. J., Clay, Patricia L., Vida, Denis, Lee, Martin R., O’Brien, Áine, Hallis, Lydia J., Stephen, Natasha R., Tartèse, Romain, Sansom, Eleanor K., Towner, Martin C., Cupak, Martin, Shober, Patrick M., Bland, Phil A., Findlay, Ross, Franchi, Ian A., Verchovsky, Alexander B., Abernethy, Feargus A. J., Grady, Monica M., Floyd, Cameron J., Van Ginneken, Matthias, Bridges, John, Hicks, Leon J., Jones, Rhian H., Mitchell, Jennifer T., Genge, Matthew J., Jenkins, Laura, Martin, Pierre-Etienne, Sephton, Mark A., Watson, Jonathan S., Salge, Tobias, Shirley, Katherine A., Curtis, Rowan J., Warren, Tristram J., Bowles, Neil E., Stuart, Finlay M., Di Nicola, Luigia, Györe, Domokos, Boyce, Adrian J., Shaw, Kathryn M. M., Elliott, Tim, Steele, Robert C. J., Povinec, Pavel, Laubenstein, Matthias, Sanderson, David, Cresswell, Alan, Jull, Anthony J. T., Sýkora, Ivan, Sridhar, Sanjana, Harrison, Richard J., Willcocks, Francesca M., Harrison, Catherine S., Hallatt, Daniel, Wozniakiewicz, Penny J., Burchell, Mark J., Alesbrook, Luke S., Dignam, Aishling, Almeida, Natasha V., Smith, Caroline L., Clark, Brett, Humphreys-Williams, Emma R., Schofield, Paul F., Cornwell, Luke T., Spathis, Vassilia, Morgan, Geraint H., Perkins, Mark J., Kacerek, Richard, Campbell-Burns, Peter, Colas, Francois, Zanda, Brigitte, Vernazza, Pierre, Bouley, Sylvain, Jeanne, Simon, Hankey, Mike, Collins, Gareth S., Young, John S., Shaw, Clive, Horak, Jana, Jones, Dave, James, Nick, Bosley, Steve, Shuttleworth, Alan, Dickinson, Paul, McMullan, Ian, Robson, Derek, Smedley, Andrew R. D., Stanley, Ben, Bassom, Richard, McIntyre, Mark, Suttle, Adam A., Fleet, Richard, Bastiaens, Luc, Ihász, Míra B., McMullan, Sarah, Boazman, Sarah J., Dickeson, Zach I., Grindrod, Peter M., Pickersgill, Annemarie E., Weir, Colin J., Suttle, Fiona M., Farrelly, Sarah, Spencer, Ieun, Naqvi, Sheeraz, Mayne, Ben, Skilton, Dan, Kirk, Dan, Mounsey, Ann, Mounsey, Sally E., Mounsey, Sarah, Godfrey, Pamela, Bond, Lachlan, Bond, Victoria, Wilcock, Cathryn, Wilcock, Hannah, Wilcock, Rob“…It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids. The near-pristine hydrogen isotopic composition of the Winchcombe meteorite is comparable to the terrestrial hydrosphere, providing further evidence that volatile-rich carbonaceous asteroids played an important role in the origin of Earth’s water.…”
Publicado 2022
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74564por Cherry, Jonathan D., Baucom, Zach H., Eppich, Kaleb G., Kirsch, Daniel, Dixon, Erin R., Tripodis, Yorghos, Bieniek, Kevin F., Farrell, Kurt, Whitney, Kristen, Uretsky, Madeline, Crary, John F., Dickson, Dennis, McKee, Ann C.“…METHODS: To better examine each tauopathy, a 71 immune-related protein multiplex ELISA panel was utilized to analyze anterior cingulate grey matter from 127 individuals neuropathologically diagnosed with AD, CTE, PSP, CBD, and AGD. …”
Publicado 2022
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74565por Pisch, Caroline, Wensch-Dorendorf, Monika, Schwarzenbolz, Uwe, Henle, Thomas, Greef, Jörg Michael, Zeyner, Annette“…Steaming did not affect CP content (native = 69, steamed = 67 g/kg dry matter, DM; p > 0.05), but it had an impact on the insoluble part of CP. …”
Publicado 2022
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74566“…All nematode channel ratio (NCR) values were above 0.5, indicating that warming did not change the decomposition pathway of soil organic matter dominated by the bacterial channels. The Wasilewska Index (WI) in the D treatment increased significantly compared to other treatments (p < 0.05), indicating that the mineralized pathway of the food web was primarily involved with Ba and fungivores nematodes (Fu), which is conducive to the growth of micro-biophagous nematodes. …”
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74567por Fan, Yuhong, Liu, Jingjing, Jin, Lei, Liu, Zhonghe, Han, Lixiang, Wang, Yue, Zhang, Yangyang, Shen, Peiming, Li, Zhi“…CONCLUSIONS: The “obesity paradox” exists regarding the prognosis of individuals aged ≥ 75, which was presented as lower long-term mortality no matter from all cause or cardio-cerebrovascular cause in patients with BMI ≥ 24. …”
Publicado 2022
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74568por Zhang, Haibo, Guan, Weikun, Li, Lizhi, Guo, Dongsheng, Zhang, Xiangfei, Guan, Jiuqiang, Luo, Runxiao, Zheng, Siying, Fu, Jiangwen, Cheng, Yingying, He, Qin“…Twenty cattle (16 ± 0.95 months) were randomly assigned to two dietary groups: CON (control, without feed additive) and NZnOC (diet supplemented with 80 mg NZnOC/kg diet dry matter basic) for 60 d. The colon digesta microbiota composition and BAs concentration were determined by microbiota metagenomics and gas chromatography methods, respectively. …”
Publicado 2022
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74569por Symeonidis, Dimitrios, Spyridakis, Michail, Zacharoulis, Dimitrios, Tzovaras, George, Samara, Athina A., Valaroutsos, Alexandros, Diamantis, Alexandros, Tepetes, Konstantinos“…However, the selection of the most proper technique for each individual case scenario is still a matter of debate. The purpose of the present study was to compare the Milligan–Morgan (MM) hemorrhoidectomy and the hemorrhoidal artery ligation and rectoanal repair (HAL–RAR) technique. …”
Publicado 2022
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74570por Beyene, Tesfalidet, Murphy, Vanessa E., Gibson, Peter G., McDonald, Vanessa M., Van Buskirk, Joe, Holliday, Elizabeth G., Vertigan, Anne E., Horvat, Jay C., Zosky, Graeme R., Morgan, Geoffrey G., Jegasothy, Edward, Hanigan, Ivan, Mattes, Joerg, Collison, Adam M., Jensen, Megan E.“…Participants’ primary residential location and fixed site monitoring was used to geolocate and estimate exposure to landscape fire-related fine Particulate Matter (PM(2.5)). RESULTS: The survey was completed by 81 pregnant, 70 breastfeeding and 232 non-pregnant and non-breastfeeding women with asthma. …”
Publicado 2022
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74571Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosispor Vasileiou, Eleni S., Hu, Chen, Bernstein, Charles N., Lublin, Fred, Wolinsky, Jerry S., Cutter, Gary R., Sotirchos, Elias S., Kowalec, Kaarina, Salter, Amber, Saidha, Shiv, Mowry, Ellen M., Calabresi, Peter A., Marrie, Ruth Ann, Fitzgerald, Kathryn C.“…In analyses with outcomes, we did not observe an association between 25(OH)D-PGS and relapse rate (per 1SD increase in 25[OH]D-PGS: 0.98; 95% CI: 0.87–1.10), EDSS worsening (per 1SD: 1.05; 95% CI: 0.87–1.28), change in T25FW (per 1SD: 0.07%; 95% CI: −0.34 to 0.49), or change in 9HPT (per 1SD: 0.09%; 95% CI: −0.15 to 0.33). 25(OH)D-PGS was not associated with new lesion accrual, lesion volume or other imaging-based outcomes (whole brain, gray, white matter volume loss or GCIPL thinning). The results were similarly null in analyses using other p value thresholds or those applying MR. …”
Publicado 2022
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74572por Kim, Dong Won, Tu, Kevin J., Wei, Alice, Lau, Ashley J., Gonzalez-Gil, Anabel, Cao, Tianyu, Braunstein, Kerstin, Ling, Jonathan P., Troncoso, Juan C., Wong, Philip C., Blackshaw, Seth, Schnaar, Ronald L., Li, Tong“…Siglecg is expressed in white-matter-associated LADAM, and expression of Siglec-10, the human orthologue of Siglecg, is progressively elevated in an AD-stage-dependent manner but not shown in non-AD tauopathy. …”
Publicado 2022
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74573por Wei, Wei, Li, Na, Du, Xianping, Sun, Zhongyi, Chen, Weiliang, Rong, Pengfei, Shi, Jian“…OBJECTIVES: To establish a better idea of the performance of neuroimage biomarker in the acute phase of mTBI, our study adopts diffusion tensor imaging (DTI) which could present the pathophysiological changes of white matter through several parameters noninvasively and combined with behavioral experiments such as intelligence quotient test, memory, executive function, and motion function to find the relationship between DTI abnormal brain regions and behavioral abnormalities. …”
Publicado 2023
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74574por Morgan, Zachariah E. M., Bailey, Maximilian J., Trifonova, Diana I., Naik, Noopur C., Patterson, William B., Lurmann, Frederick W., Chang, Howard H., Peterson, Bradley S., Goran, Michael I., Alderete, Tanya L.“…Exposure assessments included prenatal nitrogen dioxide (NO(2)) and particulate matter smaller than 2.5 and 10 microns in diameter (PM(2.5) and PM(10), respectively). …”
Publicado 2023
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74575por Lv, Zhongyue, Li, Ying, Wang, Yachen, Cong, Fengyu, Li, Xiaoyan, Cui, Wanming, Han, Chao, Wei, Yushan, Hong, Xiaojun, Liu, Yong, Ma, Luyi, Jiao, Yang, Zhang, Chi, Li, Huanjie, Jin, Mingyan, Wang, Liang, Ni, Shiwei, Liu, Jing“…Compared with baseline, the FBN analysis showed a substantial decrease in brain network energy, and the VBM analysis showed a significant increase in gray matter volume in the treatment group after NSCs treatment. …”
Publicado 2023
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74576“…Final body weight did not differ (P = 0.21) and overall dry matter intake was unaffected by dietary treatment (P ≥ 0.18). …”
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74577por Ştefănescu, Eugen Horaţiu, Mogoantă, Carmen Aurelia, Căluianu, Elena Irina, Predescu, Octavian Ion, Florou, Charoula, Chercotă, Vlad, Iovănescu, Gheorghe“…The only reasonable treatment is considered to be total tumor removal, but the appropriate surgical approach remains a matter of controversy. Over time, it went from enucleation to superficial parotidectomy (SP) and then to extracapsular dissection (ECD). …”
Publicado 2022
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74578por Li, Xuqing, Li, Dingyi, Jiang, Yugen, Xu, Jun, Ren, Xiaoxu, Zhang, Ya, Wang, Hong, Lu, Qiujun, Yan, Jianli, Ahmed, Temoor, Li, Bin, Guo, Kai“…Indeed, compared with the control, MF-HZ23 caused 30.66, 71.43, 47.31, 135.84, and 2099.90% increase in the soil pH, organic matter contents (OMC), total nitrogen (N), alkaline hydrolysis nitrogen (AHN), and available phosphorus (P), respectively. …”
Publicado 2023
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74579por Feil, Dakotah, Abrishamcar, Sarina, Christensen, Grace M., Vanker, Aneesa, Koen, Nastassja, Kilanowski, Anna, Hoffman, Nadia, Wedderburn, Catherine J., Donald, Kirsten A., Kobor, Michael S., Zar, Heather J., Stein, Dan J., Hüls, Anke“…Neurodevelopment was assessed at age 2 years using the Bayley Scores of Infant and Toddler Development, 3rd edition across four domains (cognitive development, general adaptive behavior, language, and motor function). Particulate matter with an aerodynamic diameter of 10 μm or less (PM(10)) was measured inside participants’ homes during the second trimester of pregnancy. …”
Publicado 2023
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74580por Gu, Yixin, Han, Jian, Wang, Wenjie, Zhan, Yu, Wang, Huijie, Hua, Wenyuan, Liu, Yue, Guo, Yafeng, Xue, Zhuang, Wang, Wei“…Apparent digestibility coefficient (ADC) of dry matter, protein, and lipid was significantly increased with CNE supplement (P < 0.05). …”
Publicado 2022
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