“…Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. …”
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“…Melanoma neovascularization has been correlated with poor prognosis, overall survival, ulceration and increased rate of relapse. …”
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“…The rising proportion of melanomas diagnosed at an early pathologic stage is commonly ascribed to better public education. …”
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“…BACKGROUND: Spectrophotometry (SPT) could represent a promising technique for the diagnosis of cutaneous melanoma (CM) at earlier stages of the disease. Starting from our experience, we further assessed the role of SPT in CM early detection. …”
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“…Surgical resection of uveal melanomas is an alternative eye-salvaging approach to the more commonly used irradiation techniques. …”
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“…Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. …”
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“…Oral malignant melanoma is an infrequent neoplasia making up less than 1% of all melanomas, which exhibits much more aggressive behavior than those found on the skin. …”
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“…BACKGROUND: Melanomas, highly malignant tumors arise from the melanocytes which originate as multipotent neural crest cells during neural tube genesis. …”
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“…The prognosis of patients with metastatic melanoma is poor and not influenced by systemic therapy with cytotoxic drugs. …”
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“…PURPOSE: An anorectal melanoma (AM) is a very rare tumor. However, sufficient data supporting effective surgical options for the disease do not exist. …”
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“…Black/bluish discolored skin tumor without cuticular covering de novo from site of origin could be a diagnostic feature of melanomas.…”
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“…BACKGROUND: Early detection and treatment of melanoma is important for optimal clinical outcome, leading to biopsy of pigmented lesions deemed suspicious for the disease. …”
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“…At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis. In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of advances in the fields of genomics and proteomics. …”
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“…Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. …”
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“…The identification of cancer stem cells in various malignancies led to the hypothesis that these cells have the exclusive ability of self-renewal, contribute to the plasticity of the tumours and may be the cause for ineffective cancer therapies. Several markers of melanoma stem cells have been described in recent studies including CD133, CD166, Nestin and BMI-1. …”
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“…During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. …”
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“…Cutaneous melanoma originates from pigment producing melanocytes or their precursors and is considered the deadliest form of skin cancer. …”
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